Viruses, Cell Transformation, and Cancer - 1st Edition - ISBN: 9780444504968, 9780080929439

Viruses, Cell Transformation, and Cancer, Volume 5

1st Edition

Editors: J.A. Grand
eBook ISBN: 9780080929439
Hardcover ISBN: 9780444504968
Imprint: Elsevier Science
Published Date: 20th April 2001
Page Count: 532
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Table of Contents

Introduction.

Immortalization of primary rodent cells by SV40 (A. J. Darmon, P. Jat).

Adenovirus early region 1 proteins - action through interaction (R. Grand).

Polyoma virus middle T-antigen: growth factor receptor mimic (P.R. Nicholson, S.M. Dilworth).

Pathobiology of human papillomaviruses (M. Stanley).

The function of the human papillomavirus oncogenes (D. Pim, M. Thomas, L. Banks).

Hepatitis B virus in experimental carcinogenesis studies (S. Schaefer).

Epstein-Barr virus and oncogenesis: from tumors to transforming genes (L. Young).

Human Herpes virus 8 (R. Jarrett).

Human Herpes virus &ggr;-deregulation of cell growth and apoptosis (F. Neipel, E. Meinl).

Human T-cell leukemia virus type 1 oncoprotein, Tax: Cell cycle dysregulation and cellular transformation (K.G. Low, Kuan-The Jeang).

Proviral taggin a strategy using retroviruses to identify oncogenes (T. Möröy, M. Zörnig, T. Schmidt).

Viruses and apoptosis (E. Hammond, R. Grand).

Evasion of the immune system by tumour viruses (E. Blair, N. Phillpot).

Immunity to human papilloma viruses: implications for vaccine design (J. Steele).

Recombinant adenoviruses in cancer therapy (M. Powell, G. Wilkinson).


Description

Viruses are the agent responsible for perhaps up to one million cases of cancer worldwide each year. Significantly, the study of viruses has also provided important clues to the causes and development of the most common human cancers. This volume presents an account of those viruses which have been directly associated with common human malignancies such as human papillomavirus (HPV), cervical carcinoma, Epstein-Barr virus (EBV) and Burkitt's lymphoma. In addition, the biology and biochemistry of those viruses which have been shown to be capable of transforming cells in culture are described in detail. Thus adenovirus are discussed, as are the other small DNA tumour viruses - Simian virus 40 (SV40) and polyoma virus. Consideration has also been given to human T-cell leukaemia virus (HTLV), hepatitis B virus (HBV) and human herpes virus 8 (HHV8), amongst others. General themes such as the host's immune response to viral infection, virally-induced apoptosis and the use of viruses as a delivery system in gene therapy have been discussed.

Individual chapters have been written by an international group of experts in their own field of research.


Details

No. of pages:
532
Language:
English
Copyright:
© Elsevier Science 2001
Published:
Imprint:
Elsevier Science
eBook ISBN:
9780080929439
Hardcover ISBN:
9780444504968

Reviews

@from:I. Davis @qu:...is most useful where it describes the mechanisms of interaction of viral gene products with known cellular factors such as those involved in cell cycle regulation. There are intriguing chapters on the biology of agents such as human herpesvirus-8, a relatively newly described virus involved in primary effusion lymphoma and in Kaposi's sarcoma. ...this book on viruses is not to be sneezed at. @source:Cancer Forum


About the Editors

J.A. Grand Editor

Affiliations and Expertise

CRC Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TA, UK