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Vertebrate Skeletal Development - 1st Edition - ISBN: 9780128104873, 9780128104880

Vertebrate Skeletal Development, Volume 133

1st Edition

Serial Volume Editor: Bjorn R. Olsen
Hardcover ISBN: 9780128104873
eBook ISBN: 9780128104880
Imprint: Academic Press
Published Date: 20th March 2019
Page Count: 409
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Table of Contents

1. Stem and progenitor cells in skeletal development
Noriaki Ono, Deepak H. Balani and Henry M. Kronenberg
2. ECM signaling in cartilage development and endochondral ossification
Carina Prein and Frank Beier
3. Development of the axial skeleton and intervertebral disc
Sade Williams, Bashar Alkhatib and Rosa Serra
4. Regulatory mechanisms of jaw bone and tooth development
Yuan Yuan and Yang Chai
5. Joints in the appendicular skeleton: Developmental mechanisms and evolutionary influences
Danielle Rux, Rebekah S. Decker, Eiki Koyama and Maurizio Pacifici
6. BMPs, TGFβ, and border security at the interzone
Karen M. Lyons and Vicki Rosen
7. Roles and regulation of SOX transcription factors in skeletogenesis
Véronique Lefebvre
8. Fibroblast growth factors in skeletal development
David M. Ornitz and Pierre J. Marie
9. Wnt-signaling in skeletal development
Stefan Teufel and Christine Hartmann
10. Gαs signaling in skeletal development, homeostasis and diseases
Qian Cong, Ruoshi Xu and Yingzi Yang
11. Importance of the circadian clock in tendon development
Ching-Yan Chloé Yeung and Karl E. Kadler
12. Mechanistic insights into skeletal development gained from genetic disorders
Raymond K.H. Yip, Danny Chan and Kathryn S.E. Cheah


Vertebrate Skeletal Development, Volume 133, the latest release in the Current Topics in Developmental Biology series, presents interesting chapters on a variety of topics, with this edition focusing on Craniofacial skeletal development, Regulatory mechanism of jawbone and tooth development, Development of the axial skeleton and intervertebral discs, Stem and progenitor cells in skeletal development, Origin, functioning and morphogenetic activity of limb synovial joint, ECM signaling in cartilage development and endochondral ossification, Sox genes in skeletal development, Wnt-Signaling in Skeletal Development, Gαs signaling in skeletal development and diseases, FGF signaling in skeletal development, Bone morphogenetic growth factors in bone development, and more.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Current Topics in Developmental Biology series
  • Includes the latest information on Vertebrate Skeletal Development


Clinicians in the fields of endocrinology, rheumatology, orthopedics, pediatrics and dentistry; basic scientists in anatomy, cell and developmental biology; students and postdoctoral fellows who would like to enter these fields and make further discoveries as well as improve the treatment of major bone-related disorders.


No. of pages:
© Academic Press 2019
20th March 2019
Academic Press
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Serial Volume Editor

Bjorn R. Olsen

Bjorn R. Olsen

Dr. Bjorn R. Olsen, Hersey Professor of Cell Biology at Harvard Medical School and Professor of Developmental Biology at Harvard School of Dental Medicine, received his MD and PhD degrees in 1967 from the University of Oslo, Norway. In 1971, he moved to the United States and joined the faculty at Rutgers Medical School, now Rutgers Robert Wood Johnson Medical School, where he was Professor of Biochemistry from 1976 until he moved to Harvard Medical School in 1985 as Hersey Professor of Anatomy and Cell Biology. Research in his laboratory has uncovered fundamental roles of collagens, transcription factors and receptors that affect skeletal development and homeostasis, angiogenesis and blood vessel morphogenesis. Work on the roles of extracellular proteins in tissue development led to discovery of several novel families of non-fibrillar collagens and uncovered disease mechanisms in many collagen-based osteochondrodysplasias and other disorders. Other studies identified mutations in the transcription factors HOXD13 and RUNX2 in polysyndactyly and cleidocranial dysplasia. Mapping of the genes for craniofacial disorders, such as cherubism and craniometaphyseal dysplasia led to identification of causative mutations in the siganling regulator SH3BP2, and the pyrophosphate transporter ANK. In research on pathogenetic mechanisms of vascular anomalies, the Olsen laboratory discovered that activating mutations in the receptor tyrosine kinase TIE2 cause venous malformations and identified mutations/ polymorphisms and signqling mechanisms associated with the rapid growth of infantile hemangioma, the most common tumor of infancy. By addressing questions related to skeletal development and vascular disease, the Olsen laboratory has been able to characterize complex developmental and disease mechanisms at the intersection between skeletal and vascular biology. This has recently led to new insights into unexpected intracellular mechanisms by which vascular endothelial growth factor A controls differentiation of mesenchymal stem cells to osteoblasts and adipocytes during bone development and postnatal repair. Dr. Olsen has received many awards and honors, including Honorary Doctor of Science Degrees from the University of Medicine and Dentistry of New Jersey, University of Oslo, Norway, Okayama University, Japan, and Oulu University, Finland; Research Prizes and Awards from American Association of Anatomists, American Society of Matrix Biology, International Association of Dental Research, International Society of Matrix Biology and British Society for Matrix Biology. He is Fellow of American Association of Anatomists and American Association for the Advancement of Science, and he has been the elected organizer and chair of three different Gordon Research Conferences.

Affiliations and Expertise

Harvard Medical School, Department of Cell Biology, Boston, MA, USA