Ventilation, Blood Flow, and Diffusion

Ventilation, Blood Flow, and Diffusion

1st Edition - January 28, 1980

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  • Editor: John West
  • eBook ISBN: 9780323154550

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Pulmonary Gas Exchange, Volume I: Ventilation, Blood Flow, and Diffusion considers the mechanisms of gas exchange in the lung. This volume is composed of nine chapters that particularly discuss the roles of ventilation, blood flow, and diffusion in pulmonary gas exchange. The opening chapter briefly traces the history of the chemistry and physics of pulmonary gas exchange. The next two chapters are devoted to the momentous developments that took place near the end of the Second World War advances which established the modern basis of gas. The remaining chapters describe the mechanism of gas exchange in the alveoli, how it crosses the blood-gas barrier, and the way in which ventilation-perfusion relationships determine the efficiency of exchange. This book will be of great benefit to pulmonologists and researchers in the biomedical field.

Table of Contents

  • List of Contributors


    Contents of Volume II

    1 Historical Development

    I. Introduction

    II. Knowledge prior to the Seventeenth Century

    III. Seventeenth and Eighteenth Centuries

    IV. Nineteenth Century

    V. Alveolar Gas and Dead Space

    VI. Secretion versus Diffusion

    VII. Blood Gases


    2 Development of Concepts in Rochester, New York, in the 1940s

    I. Introduction

    II. Equipment

    III. The High-Altitude Chamber

    IV. Sampling and Analysis of Alveolar Gas

    V. The Oxygen-Carbon Dioxide Diagram

    VI. The Ventilation-Perfusion Relationship

    VII. The Pressure-Volume Diagram

    IX. Retrospect



    3 Development of the Three-Compartment Model for Dealing with Uneven Distribution

    I. Cast of Characters during World War II

    II. Alveolar Gas and End-Capillary Blood

    III. The Three-Compartment Model

    IV. Reflections on a Simpler Era

    V. Newer Models for New Times


    4 Intrapulmonary Gas Mixing and Stratification

    I. Concepts and Significance

    II. Diffusion in Gas Phase

    III. Diffusion in Convective Flow

    IV. Anatomical Basis for Lung Models

    V. Mathematical Analysis of Gas Mixing in the Lung

    VI. Experimental Approaches to Identification of Stratified Inhomogeneity

    VII. Conclusions

    VIII. Appendix: Stratification in Nonmammalian Vertebrates


    5 Blood- Gas Equilibration in Lungs

    I. Equilibrium Condition

    II. Diffusion Limitation: Concept and General Model

    III. Lung Models and Experimental Designs for Determination of Pulmonary Diffusing Capacity

    IV. Problems in Application of Models to Real Lungs

    V. Gas-Blood Equilibration in Functionally Inhomogeneous Lungs

    VI. Pulmonary Diffusing Capacity


    6 Kinetics of Pulmonary Gas Exchange

    I. Experimental Techniques

    II. Oxygen Reactions

    III. Carbon Monoxide Reactions

    IV. Carbon Dioxide Reactions

    V. Kinetics of O2-CO2 Interactions

    VI. Time Course of Pulmonary O2 and CO2 Exchange

    VII. Slow pH and PCO2 Changes


    7 Ventilation-Perfusion Relationships

    I. Introduction

    II. Analysis Using PO2, PCO2, and PN2

    III. Analysis following Gas Wash-Out

    IV. Use of Foreign (Inert) Gases

    V. Ventilation-Perfusion Inequality in Disease


    8 Numerical Analysis of Gas Exchange

    I. Numerical Analysis in Steady State Gas Exchange

    II. Linear Programming in Pulmonary Gas Exchange

    III. Nonsteady State Gas Exchange


    9 Mathematical Analysis of Compartmental Lung Models

    I. Introduction

    II. Steady State Inert Gas Elimination: The Problem of Parallel Equivalence

    III. Impairment of Inert Gas Exchange in Parallel Ventilation and Perfusion Models

    IV. Impairment of Gas Exchange in Inhomogenous Lung Models: Nonlinear Dissociation Curves

    V. Inert Gas Elimination Studies without Mixed Venous Partial Pressures

    VI. Insoluble Gas Wash-Out Studies

    VII. Transient Inert Gas Transfer



Product details

  • No. of pages: 354
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: January 28, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9780323154550

About the Editor

John West

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