Vascular Smooth Muscle: Metabolic, Ionic, and Contractile Mechanisms - 1st Edition - ISBN: 9780121952204, 9780323159876

Vascular Smooth Muscle: Metabolic, Ionic, and Contractile Mechanisms

1st Edition

Editors: M.F. III Crass
eBook ISBN: 9780323159876
Imprint: Academic Press
Published Date: 28th January 1982
Page Count: 220
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Vascular Smooth Muscle: Metabolic, Ionic, and Contractile Mechanisms addresses the vascular smooth muscle function by describing plasma lipoprotein structure, synthesis, and transport in relation to the concepts of altered vascular smooth muscle lipid metabolism leading to the genesis of atherosclerotic disease. This book is organized into six chapters and begins with an introduction to the complexities of energy metabolism and how metabolic events can be correlated with a simultaneous quantitative assessment of smooth muscle mechanics and the contractile machinery at the molecular level. The next two chapters offer the reader a view of smooth muscle membrane properties in terms of the distribution, transport, and metabolic control of electrolytes and specific aspects of ion conductance and electrical activity. This text also explains how smooth muscle cells regulate their contractile activity through regulation of calcium ion fluxes and the interaction, at the molecular level, of calcium ions with regulatory proteins associated with the contractile apparatus. Reference is made to the relation of possible anomalies in cellular or subcellular smooth muscle metabolic and/or ionic events to the bases of certain types of vascular disease. A chapter that examines the events leading to vascular pathology in the form of atherogenesis concludes the book. This book is intended for researchers and clinicians engaged in the study of smooth muscle and related areas.

Table of Contents

List of Contributors Preface

  1. Vascular Smooth Muscle: Relations between Energy Metabolism and Mechanics I. Introduction II. Relations between Metabolism and Contractility in Vascular Smooth Muscle III. Relations between Metabolism and Contractility—Current Questions IV. Mechanisms and Energetics of Contraction V. Coordination of Metabolism and Contractility VI. Applied Aspects of Smooth Muscle Mechanochemistry: Hypertension VII. Summary and Perspectives References
  2. Electrolyte Metabolism of the Arterial Wall I. Introduction II. Electrolyte Distribution III. Electrolyte Transport IV. Metabolic Control References
  3. Membrane Electrical Activation of Arterial Smooth Muscle I. Introduction II. Membrane Potential (Em) of Arterial Smooth Muscle as a Function of External K+ ([K])o III. K+ Conductance (gK) and Electrical Activity IV. Importance of Em in Controlling the Active State of Arterial Smooth Muscle V. Summary References
  4. Current Status of Vascular Smooth Muscle Subcellular Calcium Regulation I. Introduction II. Physiological Heterogeneity III. Subcellular Calcium Regulation: Biochemical Approaches IV. Cyclic Adenosine 3’,5'-Monophosphate and Calcium Regulation V. Hypertension and Subcellular Calcium Regulation VI. Summary and Conclusions References
  5. The Contractile Apparatus of Smooth Muscle and Its Regulation by Calcium I. Introduction II. Contractile Apparatus III. Types of Regulatory Mechanisms IV. Regulatory Mechanisms in Vertebrate Smooth Muscle References
  6. Lipid Transport and Atherogenesis: Role of Apolipoproteins I. Introduction II. Lipoprotein Composition III. Lipoprotein Structure IV. Apoprotein Structure, Metabolism, Function, and Role in Disease V. Lipid Transport and Atherosclerosis VI. Summary References Index


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© Academic Press 1982
Academic Press
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M.F. III Crass

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