Description

This volume of Progress in Brain Research is based on the proceedings of a conference, "Using Eye Movements as an Experimental Probe of Brain Function," held at the Charing Cross Hospital Campus of Imperial College London, UK on 5th -6th December, 2007 to honor Professor Jean Büttner-Ennever. With 87 contributions from international experts – both basic scientists and clinicians – the volume provides many examples of how eye movements can be used to address a broad range of research questions. Section 1 focuses on extraocular muscle, highlighting new concepts of proprioceptive control that involve even the cerebral cortex. Section 2 comprises structural, physiological, pharmacological, and computational aspects of brainstem mechanisms, and illustrates implications for disorders as diverse as opsoclonus, and congenital scoliosis with gaze palsy. Section 3 addresses how the cerebellum transforms neural signals into motor commands, and how disease of such mechanisms may lead to ataxia and disorders such as oculopalatal tremor. Section 4 deals with sensory-motor processing of visual, vestibular, somatosensory, and auditory inputs, such as are required for navigation, and gait. Section 5 illustrates how eye movements, used in conjunction with single-unit electrophysiology, functional imaging, transcranial magnetic stimulation, and lesion studies have illuminated cognitive processes, including memory, prediction, and even free will. Section 6 includes 18 papers dealing with disorders ranging from congenital to acquired forms of nystagmus, genetic and degenerative neurological disorders, and treatments for nystagmus and motion sickness.

Key Features

* Clinicians will find important new information on the substrate for spinocerebellar ataxia, late-onset Tay-Sachs disease, Huntington disease, and pulvinar lesions * Organizes multiple articles on such topics as proprioception, short and longer-term memory, and hereditary cerebellar ataxias for a more coherent presentation * Articles on anatomic tracers, functional imaging, and computational neuroscience are illustrated in color

Readership

Neuroscientists, neurologists, opthalmologists, cognitive neuroscientists, and visual sciences.

Details

No. of pages:
652
Language:
English
Copyright:
© 2008
Published:
Imprint:
Elsevier Science
Print ISBN:
9780444531636
Electronic ISBN:
9780080932323

About the editors

R. Leigh

Affiliations and Expertise

Department of Neurology, Case Western Reserve University, School of Medicine, Cleveland, OH, USA

Christopher Kennard

Affiliations and Expertise

Academic Unit of Neuroscience, Charing Cross Hospital, London, UK Professor of Clinical Neurology