This volume of Progress in Brain Research is based on the proceedings of a conference, "Using Eye Movements as an Experimental Probe of Brain Function," held at the Charing Cross Hospital Campus of Imperial College London, UK on 5th -6th December, 2007 to honor Professor Jean Büttner-Ennever. With 87 contributions from international experts – both basic scientists and clinicians – the volume provides many examples of how eye movements can be used to address a broad range of research questions. Section 1 focuses on extraocular muscle, highlighting new concepts of proprioceptive control that involve even the cerebral cortex. Section 2 comprises structural, physiological, pharmacological, and computational aspects of brainstem mechanisms, and illustrates implications for disorders as diverse as opsoclonus, and congenital scoliosis with gaze palsy. Section 3 addresses how the cerebellum transforms neural signals into motor commands, and how disease of such mechanisms may lead to ataxia and disorders such as oculopalatal tremor. Section 4 deals with sensory-motor processing of visual, vestibular, somatosensory, and auditory inputs, such as are required for navigation, and gait. Section 5 illustrates how eye movements, used in conjunction with single-unit electrophysiology, functional imaging, transcranial magnetic stimulation, and lesion studies have illuminated cognitive processes, including memory, prediction, and even free will. Section 6 includes 18 papers dealing with disorders ranging from congenital to acquired forms of nystagmus, genetic and degenerative neurological disorders, and treatments for nystagmus and motion sickness.

Key Features

* Clinicians will find important new information on the substrate for spinocerebellar ataxia, late-onset Tay-Sachs disease, Huntington disease, and pulvinar lesions * Organizes multiple articles on such topics as proprioception, short and longer-term memory, and hereditary cerebellar ataxias for a more coherent presentation * Articles on anatomic tracers, functional imaging, and computational neuroscience are illustrated in color


Neuroscientists, neurologists, opthalmologists, cognitive neuroscientists, and visual sciences.

Table of Contents

Section 1: Using Novel Techniques to Define the Neural Substrate for Eye Movements Jean Büttner-Ennever, Munich: Re-mapping the oculomotor system Joseph Demer, Los Angeles: Using high-definition MRI to re-define the mechanics of eye rotations Michael Goldberg, New York: The cortical representation of oculomotor proprioception David Zee, Baltimore: How new knowledge of the anatomy of the eye muscles and their innervation translates into improved treatment of patients with ocular motor palsies Paul Knox, Liverpool: Testing the influences of extraocular proprioception in humans James Sharpe, Toronto: Reinterpreting palsies of the ocular motor nerves Dominik Straumann: New insights into trochlear nerve palsy Paul May: Anatomical insights into peripheral gaze control Louis Dell'Osso: How disrupting ocular proprioception can be therapy for congenital nsyatgmus Section 2: New Insights into Brainstem Generation of Ocular Motor Commands Anja Horn, Munich: New insights into the circuitry and pharmacology of the brainstem reticular formation Edward Keller, San Francisco: Using multiple electrode arrays to map moving fields of neural activity in the superior colliculus Paul Gamlin, Birmingham: Synthesis of vergence control by brainstem circuits Holger Rambold, Lübeck: Disturbances of vergence and saccadic eye movements by human brainstem lesions Christoph Helmchen, Luebeck: Understanding how the cerebellar disease could cause saccadic oscillations Stefano Ramat, Pavia: A brainstem network that accounts for abnormal saccades Mark Gibson, Belfast: Human saccadic disorders and their brainstem mechanisms Richard Clement: A black-box approach to saccadic disorders Section 3: Using


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© 2008
Elsevier Science
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