Unraveling the Complexities of Metastasis

Transition from a Segmented View to a Conceptual Continuum

1st Edition - May 14, 2022
Editors: Ammad Ahmad Farooqi, Muhammad Zahid Qureshi, Uteuliyev Yerzhan Sabitaliyevi
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 7 8 9 - 4
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 7 9 0 - 0

Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasi… Read more

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Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasis research and how progress can be further enhanced in the field. Metastasis is a highly complicated mechanism and prognostic analysis of different metastatic patterns in advanced cancer patients is becoming increasingly problematic. It is therefore essential to take a step back and focus on the underlying mechanisms of metastasis before moving ahead for effective translation of laboratory findings to clinically effective therapeutics. This book is surely helpful in putting together missing pieces of an incomplete jig-saw puzzle of molecular cancer.

The book discusses topics such as the role of TRAIL-mediated signaling, late metastasis and mechanisms underlying tumor cell dormancy, CTCs and exomes, non-coding way of metastasis, and stem cells. Additionally, it brings relevant and updated information on nanotechnology-based docetaxel and the peculiarities of cancer cell metabolism.

This book is a valuable source for cancer researchers, medical doctors and several members of biomedical field who need to understand better the complex mechanism of metastasis.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Chapter 1. Role of TRAIL-mediated signaling as Jekyll and Hyde in metastasis: changing places, changing faces
Introduction
Darker side of caspase-8: nonapoptotic caspase-8–mediated functionalities
TRAIL-mediated NF-κB activation: friend or foe
Concluding remarks
Chapter 2. Multiple roles of circulating tumor cells and exosomes in cancer metastasis: implications for therapeutic intervention
Introduction
CTCs involvement in metastatic progression
Exosomes involvement in metastatic progression
Clinical impact of CTCs and exosomes
Conclusions and future perspectives
Chapter 3. Diagnosis and treatment of metastatic prostate cancer: the role of imaging, liquid biopsies, and biomarkers for deciphering tumor heterogeneity
Introduction
Overview of prostate cancer disease states and treatment options
Improved imaging and image-guided biopsy for prostate cancer
Gene signature panels for prostate cancer risk stratification
Next-generation sequencing and prostate cancer: cell-free nucleic acids and circulating tumor cells
Conclusion
Chapter 4. Prognostic and predictive role of bone metastasis in NSCLC: risk factors and clinical implications
Introduction
Incidence of BMs in NSCLC patients
Prognostic role
Predictive role
Risk factors for bone metastasis
Clinical implication and treatment
Conclusion
Chapter 5. Brain metastases in breast cancer
Introduction
The basis of breast cancer brain metastasis
Risk factors for brain metastasis in breast cancer
Diagnosis
Treatment
Prognosis
Specific conditions
Chapter 6. Noncoding way of the metastasis
Introduction
Dual role of small noncoding RNAs in metastasis
Long noncoding RNAs and metastasis
Future perspectives
Chapter 7. Nanotechnology based docetaxel: upcoming avenue for breast cancer management
Introduction
Classification of breast cancer
Pathogenesis of breast cancer
Causative factors and associated risks of breast carcinoma
Mortality
Stages of breast cancer
Diagnosis
Treatment strategies for breast cancer
Nanoparticle platforms currently employed or explored clinically in MBC
Conclusion
Chapter 8. Metastasis in gynecological cancers
Introduction
Key steps and patterns of metastasis among gynecological cancers
Endometrial cancer
Cervical cancer
Ovarian cancer
Vulvar cancer
Vaginal cancer
Metastasectomy
Future directions: targeted therapy
Conclusions
Chapter 9. Regulation of HSP90 by noncoding RNAs in carcinogenesis and metastasis: harbingers of good or evil
Introduction
Oncogenic role of HSP90 and miRNAs
Tumor suppressive role of HSP90 and miRNAs
Targeting of HSP90 by tumor suppressor miRNAs
Regulation of HSP90 by lncRNAs
Tumor suppressor lncRNAs
Partnership of lncRNAs with HSP90 to promote stability of oncogenic proteins: oncogenic role of lncRNAs
Partnership of lncRNAs with HSP90 to promote stability of tumor suppressor proteins: tumor suppressor role of lncRNAs
LncRNAs protect HSP90 from targeting by miRNAs
Regulation of HSP90 by circular RNAs
Concluding remarks
Chapter 10. Role of circular RNAs in carcinogenesis and metastasis: closer analysis of unresolved mysteries
Introduction
Tumor suppressor circular RNAs
Oncogenic role of circular RNAs
Concluding remarks
Chapter 11. Metastatic potential: focus on lipid transport with emphasis on CD36
Introduction
Cellular lipids for metastasis—where do they come from?
Families of lipid transporters—positioning in classifications
Dietary lipids can drive metastasis
Supporting cancer cell colonization—pro-survival signalling
Signaling via exosomes
Low metastatic potential versus high metastatic potential
CD36 - a special player?
Conclusion
Chapter 12. Developmental genes: the bridge between development and cancer metastasis
Introduction
Transforming growth factor beta
WNT
Sonic hedgehog
Notch
Fibroblast growth factor
Conclusion
Chapter 13. Heat shock proteins in tumor progression and metastasis
Introduction
Structure–function relationship of HSPs
Role of distinct HSPs in oncogenic progression and in metastasis
Epigenetic alterations of HSPs in cancer
Posttranslational modifications of HSP90
microRNA-mediated regulation of heat shock proteins in different cancers
Diagnostic, prognostic, and predictive implications of diverse classes of HSP
HSP inhibitors
Conclusion
Chapter 14. Role of kisspeptin-mediated signaling pathway in carcinogenesis and metastasis: opposite sides of the same coin
Introduction
Antimetastatic role of KISS1
Prometastatic role of kisspeptin-driven signaling
Regulation of kisspeptin by noncoding RNAs
Concluding remarks
Chapter 15. Tumor microenvironment manipulation and cancer metastasis (taming the beast)
Introduction
Invasion and metastasis
The complexity of metastatic colonization
The tumor microenvironment
Tumor genesis and metastasis
Epithelial–mesenchymal transition
Relation between epithelial mesenchymal transition and vascularization
Component of tumor microenvironment
Implication in translational research
Targeting TME in therapy
Futures research and challenges
Understanding TMI for effective immunotherapy
Chapter 16. Metastasis inhibitory role of hydroxycinnamic acid and its derivatives
Introduction
Hydroxycinnamic acid
Ferulic acid
Caffeic acid
Concluding remarks
Chapter 17. Regulatory role of SMURF1 and SMURF2 in metastasis: multitalented SMURFs take the central stage
Introduction
Prometastatic role of SMURF1
Metastasis inhibitory role of SMURF1
SMURF2
Darker side of SMURF2
Concluding remarks
Chapter 18. Antimetastatic effects of curcumin
Introduction of curcumin
Metastasis inhibitory role of curcumin
Curcumin and nanotechnology
Concluding remarks
Chapter 19. Metastasis inhibitory role of blueberries: time to play gooseberry with oncogenic cascades and metastasis
Introduction
Inhibition of carcinogenesis and metastasis by different berries: preclinical studies
Metastasis inhibitory roles of blueberry
Concluding remarks
Chapter 20. The role of ATP-binding cassette transporter genes in the metastatic process of epithelial thyroid carcinoma with aggressive behavior
Introduction
The EMT process in thyroid cancer progression
ABC-binding cassette transporters in ETC progression
Future perspectives: the ABC transporters and EMT paradigm in ETC
Chapter 21. The role of epigenetics in cancer metastasis
Introduction
DNA methylation and metastasis
Histone modifications
Noncoding RNA
Exosomes and premetastatic niche formation
Clinical correlations
Conclusions
Chapter 22. Regulation of angiogenesis in tumor metastasis via Ets-related ERG and micro-RNAs; one hand washes the other
ERG structure
ERG functions
Crosstalk of ERG with other proteins or signaling cascades
ERG regulation
ERG can turn the table
Conclusion
Index

Ammad Ahmad Farooqi

Ammad Ahmad Farooqi is currently serving as a Senior Scientist at Institute of Biomedical and Genetic Engineering (IBGE). His research-work is tightly focused on cell signaling cascades and how these pathways can be therapeutically exploited. He has published more than 200 articles in International peer-reviewed Journals and has guest edited 2 Books. He has over 5000 citations and an H-index above 37. He is editor of various national and international Journals. He has guest edited various thematic issues related to molecular oncology. He has authored/co- authored more than 25 chapters in various books published by internationally distinguished publishers. He was ranked in the top 10 scientists of biological sciences for 2017/2018 by most prestigious national research steering body, Pakistan Council of Science and Technology (PCST). He was ranked in top 2% scientists of the world in the field of oncology in 2019/2020. According to recently published research, he was ranked as No. 1 Scientist in the field of breast cancer research in Pakistan.

Affiliations and expertise

Senior Scientist, Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan

Muhammad Zahid Qureshi

Muhammad Zahid Qureshi, PhD is a Professor of Biochemistry in Qassim University, Saudi Arabia. He received his PhD from Quaid-i-Azam University Islamabad and post-doctorate from Brunel University, London. He has notable contributions in Biochemistry and Molecular Biology. He has authored/co-authored many articles in international Journals and has published seven chapters. His research is focused on molecular cancer and nanotechnology.

Affiliations and expertise

Professor of Biochemistry, Government College University, Lahore, Pakistan Professor of Biochemistry, Qassim University, Malidah Al Qassim, Saudi Arabia

Uteuliyev Yerzhan Sabitaliyevi

Uteuliyev Yerzhan Sabitaliyevich is an academician and reputed scientist from Kazakhstan. He has previously served as a Vice-Rector for academic affairs and research and innovation activities of Kazakhstan Medical University "KSPH". He has notable contributions in scientifically distinguished international journals. He has played key role in inspiring young researchers to make progress in medical field. He has organized series of medical conferences in Kazakhstan to maximize the interaction of local researchers with scientifically eminent researchers from technically advanced countries.

Affiliations and expertise

Scientific Center for Innovative Technologies and Research, Kazakhstan