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Understanding Pulmonary Pathology - 1st Edition - ISBN: 9780128013045, 9780128014462

Understanding Pulmonary Pathology

1st Edition

Applying Pathological Findings in Therapeutic Decision Making

Author: Richard Kradin
Paperback ISBN: 9780128013045
eBook ISBN: 9780128014462
Imprint: Academic Press
Published Date: 25th October 2016
Page Count: 356
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Understanding Pulmonary Pathology: Applying Pathological Findings in Therapeutic Decision Making provides a much needed reference tool for pathologists, practicing pulmonologists, and pulmonologist researchers. The unique approach to pulmonary pathology combines the multi-perspective views of the author who was trained formally as both a pulmonologist and as a pathologist.

The book addresses what is often lost in translation when conveying the experience of pulmonary pathology in practicing pulmonary medicine. This important tool conveys detailed information concerning the anatomic basis of disease to those oriented towards thinking about diseases physiologically, providing the opportunity for optimal diagnosis, treatment of patients, and advancement of research.

Key Features

  • Bridges the knowledge gap between the pathologist, practicing pulmonologist, and pulmonologist researcher
  • Contains a one-of-a-kind index that lists pathological terms and describes how they relate to disease diagnosis and impact pulmonary function
  • Includes the current international guidelines with a critical analysis of how pathology is reflected within them
  • Provides full-color, microscopic pictures on referenced topics


Pulmonology researchers, Pulmonologists and Pathologists

Table of Contents

  • Acknowledgments
  • Introduction
  • Chapter 1. Approach to the Sampling of the Lung
    • Handling of the Samples
    • Histochemical Stains
    • Immunostains
  • Chapter 2. Anatomy of the Lung
    • Gross Pulmonary Anatomy
    • Airway Anatomy
    • Pulmonary Vessels
    • Bronchial Circulation
    • Pulmonary Lymphatics
    • The Elastic Structure of the Lungs
    • Pleura
    • Pulmonary Vascular Elastic Fibers
    • Immune Anatomy
  • Chapter 3. Pulmonary Responses to Injury
    • Acute Inflammation
    • Chronic Inflammation
    • Fibrosis
    • Histiocytic (Macrophage) Reactions
    • The Airway Wall
    • The Alveolar Interstitium
    • Pulmonary Vessels
    • Pleura
  • Chapter 4. The Radiographic Patterns of Common Lung Diseases
    • Introduction
    • Airway Diseases
    • Small Airways Disease
    • Direct Signs
    • Indirect Signs
    • Infection
    • Diffuse Lung Disease
    • Lung Neoplasia
  • Chapter 5. Diseases of the Airways
    • Asthma
    • Chronic Obstructive Pulmonary Disease
    • Chronic Bronchitis
    • Emphysema
    • Exacerbations of COPD
    • Bronchiectasis
    • Cystic Fibrosis
    • The Small Airways
    • Obliterative Bronchiolitis
    • Bronchiolitis Obliterans Organizing Pneumonia
    • Follicular Bronchiolitis
    • Diseases of the Upper Airways
    • Tracheal Stenosis
    • Other Tracheobronchial Disorders
    • Relapsing Polychondritis
    • Tracheopathia Osteoplastica
    • Tracheobronchomalacia
  • Chapter 6. Interstitial Lung Disease
    • Usual Interstitial Pneumonitis
    • Management
    • Nonspecific Interstitial Pneumonitis
    • Lymphocytic Interstitial Pneumonitis
    • Hypersensitivity Pneumonitis
    • Diffuse Alveolar Damage/Acute Interstitial Pneumonia
    • Acute Interstitial Pneumonia
    • Diffuse Alveolar Injury With Delayed Alveolar Re-Epithelialization
    • Other Poorly Defined Entities
    • Sarcoidosis
    • Granulolymphocytic Interstitial Lung Disease
    • Pleuro-Pulmonary Fibroelastosis
    • IgG4-Mediated Lung Disease
  • Chapter 7. Nonneoplastic Smoking-Related Disorders
    • Respiratory Bronchiolitis (Interstitial Lung Disease)
    • Desquamative Interstitial Pneumonitis
    • LCH (or Eosinophilic Granuloma)
    • Smoking-Related Interstitial Fibrosis
  • Chapter 8. Pulmonary Vascular Disorders
    • Pulmonary Arterial Hypertension
    • Idiopathic Pulmonary Arterial Hypertension
    • Pulmonary Veno-occlusive Disease
    • Pulmonary Capillary Hemangiomatosis
    • Other Causes of Pulmonary Vascular Disease
    • Pulmonary Thromboembolic Disease
    • Chronic Thromboembolic Pulmonary Hypertension
    • Other Forms of Pulmonary Thromboembolic Disease
    • Tumor Emboli
    • Pulmonary Angiitis
    • GPA—Wegener's Granulomatosis
    • Pulmonary Alveolar Hemorrhage Syndromes
    • Antialveolar Basement Membrane Disease or Goodpasture's Disease
    • Drug-Induced Angiitis
    • Arteriovenous Malformations
  • Chapter 9. Pulmonary Infection
    • The Approach to Sampling for Infection
    • Transbronchial Biopsy
    • Fine Needle Aspiration Biopsy
    • Transbronchial Needle Aspiration Biopsy
    • Video-Assisted and Open Thoracoscopic Biopsy
    • Handling Lung Biopsies
    • Pulmonary Injury in Infection
    • RNA Viruses
    • DNA Viruses
    • Other “Atypical Pneumonias”
    • Protozoa
    • Nematodes (Round Worms)
    • Microbes Associated With Bioterrorism
  • Chapter 10. Lung Cancer
    • Squamous Cell Carcinoma
    • Small-Cell and Large-Cell (Neuroendocrine) Carcinoma
    • Adenocarcinoma
    • Multiple Tumors
    • Molecular Analysis
    • Immunohistology
    • Large-Cell Undifferentiated Carcinoma
    • Pleomorphic Carcinomas
    • Malignant Melanoma
    • Metastatic Carcinoma
    • Sarcomas of the Lung
    • Tumors of Intermediate Malignant Potential
    • Salivary Gland Tumors
    • Mucoepidermoid Tumors
    • Adenoid Cystic Carcinoma
    • Mixed Tumors
    • Benign Tumors
    • Sclerosing Hemangioma
    • Benign Clear Cell “Sugar” Tumor (Perivascular Cell Tumor)
    • Glomus Tumors
    • Squamous Papillomas
    • Alveolar and Papillary Adenoma
    • Benign Tumorlets
  • Chapter 11. Lymphoid Lesions
    • Benign Intrapulmonary Lymph Nodes
    • Nodular Lymphoid Hyperplasia
    • Lymphoid Interstitial Pneumonitis
    • Lymphomatoid Granulomatosis
    • Extranodal Marginal Zone B-Cell Lymphoma (MALT Lymphoma)
    • Primary B-Cell Lymphoma
    • Hodgkin's Lymphoma
    • Intravascular Large B-Cell Lymphoma
    • T-Cell Lymphoma
    • Leukemia
  • Chapter 12. Iatrogenic Lung Diseases
    • Drug-Induced Pneumonitis
    • Opiate-Induced Changes
    • Amiodarone
    • Methotrexate
    • Mesalamine
    • Sulfonamides
    • Cytotoxic Drugs
    • Radiation
    • Nitrofurantoin
    • Transfusion-Related Acute Lung Injury
    • Newer Drugs
  • Chapter 13. Toxic Exposures
    • Toxic Gases
    • Asbestos
    • Asbestos-Related Cancer
    • Talcosis
    • Silicosis
    • Silicatosis
    • Coal Worker's Pneumoconiosis
    • Hard Metal Pneumoconiosis
    • Beryllium Disease
    • Siderosis
    • Aluminosis
  • Chapter 14. Sundry Disorders
    • Pulmonary Edema
    • Dendriform Ossification
    • Alveolar Microlithiasis
    • Dystrophic Calcification
    • Aspiration Pneumonia
    • Food
    • Lipid Aspiration
    • Cocaine Inhalation (“Crack”)
    • Amyloidosis
    • Hyalinizing Granuloma
    • Pulmonary Alveolar Lipoproteinosis
    • Pulmonary Scars
    • Lymphangioleiomyomatosis
    • Chronic Eosinophilic Pneumonia
  • Chapter 15. Pulmonary Transplant Pathology
    • Acute Allograft Rejection
    • Airways Inflammation
    • Chronic Graft Airway Rejection
    • Chronic Vascular Rejection
    • Humoral Rejection
    • Other Forms of Graft Injury
    • Postimplantation Response
    • Aspiration
    • Posttransplant Lymphoproliferative Disorder
    • Recurrence of Disease in an Allograft
  • Chapter 16. Pediatric Lung Disease
    • Hyaline Membrane Disease
    • Sequestrations
    • Intralobar Sequestration
    • Bronchial Atresia and Congenital Cystic Adenomatoid Malformation
    • Neuroendocrine Hyperplasia of Childhood
    • Interstitial Lung Diseases
    • Surfactant Protein Deficiency
    • ABCA3 Deficiency
    • Surfactant-Protein C Deficiency
    • Malignant Tumors
  • Chapter 17. Pleural Diseases
    • Reactive Fibrinous Pleuritis
    • Pleural Plaques
    • Benign Tumors of the Pleura
    • Desmoid Tumors
    • Neural Tumors
    • Metastatic Pleural Tumors
    • Malignant Mesothelioma
    • Rare Pleural Malignancies
  • Glossary of Terms
  • Index


No. of pages:
© Academic Press 2017
25th October 2016
Academic Press
Paperback ISBN:
eBook ISBN:

About the Author

Richard Kradin

Dr. Kradin began his medical career at Jefferson Medical College in Philadelphia, Pennsylvania. He then went on to complete residencies at both Massachusetts General Hospital and Pennsylvania Hospital. He is board certified in Internal Medicine and Pulmonary Disease by the American Board of Internal Medicine as well as being certified in Anatomic Pathology by the American Board of Pathology.

Dr. Kradin has a number of clinical interests including Chronic Fatigue Syndrome, Interstitial Lung Disease, Multiple Chemical Sensitivity and Pulmonary Immunology.

He also holds an Associate Professor position of Pathology at Harvard Medical School. There, he has been a director of a course on current concepts in asbestos related pulmonary disease. Dr. Kradin is also an Associate Pathologist at Massachusetts General Hospital in the Immunopathology Unit. His techniques include tissue culture and immunocytochemistry, flow cytometry, Northern blotting and immunocytochemistry. Dr. Kradin has authored and co-authored a number of scholarly articles including "Complete pulmonary venous occlusion after radiofrequency ablation for atrial fibrillation" which was published in the Annals of Thoracic Surgery in January 2009. He also co-authored "Nodular amiodarone lung disease" published in the American Journal of Surgical Pathology in November of 2008.

Affiliations and Expertise

Associate Pathologist and Associate Physician, Department of Pathology and Pulmonary/Critical Care Unit, Massachusetts General Hospital, Boston, MA, USA. Associate Professor in Pathology and Associate Professor in Medicine, Harvard Medical School, Boston, MA

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