Ultrastructural Pathology of the Cell and Matrix

Ultrastructural Pathology of the Cell and Matrix

A Text and Atlas of Physiological and Pathological Alterations in the Fine Structure of Cellular and Extracellular Components

3rd Edition - November 25, 1988

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  • Author: Feroze N. Ghadially
  • eBook ISBN: 9781483192093

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Ultrastructural Pathology of the Cell and Matrix: Third Edition Volume 2 presents a comprehensive examination of the intracellular lesion. It discusses the analysis of pathological tissues using electron microscope. It addresses the experimental procedures made on the cellular level. Some of the topics covered in the book are the structure, distribution, and variations of rod-shaped microtubulated bodies; morphology of intracytoplasmic filaments; melanosome-producing and melanosome-containing cells in tumours; myofilaments in striated muscle; and pathological variations in size, shape, and numbers of microbodies. The intracytoplasmic and intranuclear annulate lamellae are fully covered. An in-depth account of the classification, history, and nomenclature of lysosomes are provided. The morphology and normal variations of melanosomes and anchoring fibrils are completely presented. A chapter is devoted to the endocytotic structures and cell processes. Another section focuses on the classification and nomenclature of fibrous components. The book can provide useful information to cytologists, pathologists, students, and researchers.

Table of Contents

  • 7 Lysosomes

    Introduction (History, Classification and Nomenclature)

    Heterolysosomes and Autolysosomes

    Lamellar Cup-Shaped Lysosomes

    Multivesicular Bodies and R-Bodies

    Lipofuscin (Residual Bodies)

    Myelinoid Membranes, Myelin Figures and Myelinosomes

    Erythrophagosomes and Erythrophagolysosomes

    Siderosomes, Haemosiderin and Ferritin

    Lysosomes and Residual Bodies in Tumours

    Lysosomes in Erythrocytes

    Lysosomes in Neutrophil Leucocytes

    Lysosomes in Eosinophil Leucocytes

    Lysosomes in Monocytes and Macrophages

    Lysosomes in Melanosis Coli and Some Other Melanoses

    Lysosomes in Melanosis Duodeni

    Lysosomes in Malakoplakia

    Lysosomes in Granular Cell Tumors

    Lysosomes in Rheumatoid Arthritis

    Lysosomes in the Liver of the Tumor-Bearing Host

    Angulate Lysosomes

    Lysosomes in Mucopolysaccharidoses

    Lysosomes in Metachromatic Leucodystrophy (Sulphatoidosis)

    Curvilinear Bodies in Lysosomes

    Collagen in Lysosomes

    Glycogen in Lysosomes (Glycogenosomes)

    Metals in Lysosomes



    Interlysosomal Crystalline Plates (Zipper-like Structures)


    8 Microbodies (Peroxisomes, Microperoxisomes and Catalosomes)


    Structure and Normal Variations

    Pathological Variations in Size, Shape and Numbers


    9 Melanosomes


    Morphology and Normal Variations

    Alterations in Melanosomes in Melanomas and Pigmentary Disorders

    Granular Melanosomes

    Balloon Melanosomes

    Giant Melanosomes

    Melanosome-Producing and Melanosome-Containing Cells in Tumors


    10 Rod-Shaped Microtubulated Bodies


    Structure, Distribution and Variations

    Rod-Shaped Microtubulated Body in Vasoformative Tumors


    11 Intracytoplasmic Filaments


    Myofilaments in Striated Muscle

    Ring Fibers

    Myofibrillary Degeneration

    Morphological Alterations of the Z-Line

    Myofilaments in Rhabdomyoma and Rhabdomyosarcoma

    Myofilaments in Smooth Muscle

    Myofilaments in Leiomyoma and Leiomyosarcoma

    Myofilaments in Cells Other than Muscle

    Myofibroblasts and Myofibroblastoma

    Intermediate Filaments in Normal and Pathological States (Including Neoplastic)

    Mallory's Bodies

    Globular Filamentous Bodies

    Crystals and Crystalloids of Intracytoplasmic Filaments

    Crystalline Filamentous Cylinders

    Asteroid Bodies


    12 Microtubules


    Structure, Function and Variations


    13 Cytoplasmic Matrix and Its Inclusions


    The Dark Cell-Light Cell Phenomenon

    Dark and Light Cells in Tumors


    Polyglucosan Bodies (Corpora Amylacea, Lafora's Bodies, Lafora-like Bodies, Bielschowsky's Bodies and Amylopectin Bodies)


    Crystalline Inclusions


    Heinz Bodies

    Porphyrin Inclusions

    Intracellular and Intracytoplasmic Collagen

    Intracytoplasmic Banded Structures

    Intracytoplasmic Desmosomes

    Intracytoplasmic Canaliculi and Lumina

    Intracytoplasmic Nucleolus-like Bodies (Nematosome, Nuage, Dense Body, Honey-Comb Body, Ribosomal Body)

    Viral Inclusions


    14 Cell Membrane and Coat


    Cell Membrane

    T-Tubule Networks

    Basement Membrane and Basal Lamina

    Alterations in the Basal Lamina

    Basal Lamina in Alport's Syndrome

    Basal Lamina in Dense Deposit Disease

    Coat of Free Surfaces

    External Lamina

    Glycocalyceal Bodies and Filamentous Core Rootlets

    Spherical Microparticles

    Crystals in Basal Lamina (Striated Lamellar Structures, Fibrin and Others)


    15 Cell Junctions


    Structure and Function of Cell Junctions

    Alterations of Cell Junctions in Neoplasia

    Diagnostic Value of Cell Junctions in Tumors

    Cell Junctions in Connective Tissues and Haemopoietic Tissues


    16 Endocytotic Structures and Cell Processes


    Endocytotic Vesicles and Vacuoles

    Micropinocytosis Vermiformis

    Langerhans' Cell Granules (Birkbeck's Granules)


    Cytoplasmic Bubbling, Blebs and Blisters

    Microvilli and Stereocilia

    Morphological Alterations in Microvilli


    Cell Processes in Hairy Cell Leukaemia

    Ropalocytes and Ropalopodia

    Uropod of the Lymphocyte

    Foot Processes of Podocytes

    Cilia, Flagella and Sperm Tails

    Single, Primary or Oligocilia

    Atypical Cilia

    Atypical Basal Bodies (Half Centrioles, Giant Centrioles and Others)

    Immotile Cilia Syndrome


    17 Extracellular Matrix (Extracellular Components)

    Introduction (Classification and Nomenclature of Fibrous Components)

    Collagen, Filaments, Fibrils and Fibers

    Collagen in Fossils and Mummies

    Anchoring Fibrils

    Spiny Collagen

    Fibrous Long-Spacing Collagen

    Segment Long-Spacing Collagen

    Giant Collagen Fibrils and Amianthoid Fibers

    Spiralled Collagen (Poorly Packed Collagen and Frayed Collagen)

    Elastic Fibers, Elaunin Fibers and Oxytalan Fibers

    Calcified Elastic Fibers



    Proteoglycan Particles (Matrix Granules)

    Calcification (Matrical Lipidic Debris, Matrix Vesicles, Calcifying Collagen and Calcifying Secretions)




Product details

  • No. of pages: 775
  • Language: English
  • Copyright: © Butterworth-Heinemann 1988
  • Published: November 25, 1988
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483192093

About the Author

Feroze N. Ghadially

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