Ultrastructural Pathology of the Cell and Matrix

Ultrastructural Pathology of the Cell and Matrix

A Text and Atlas of Physiological and Pathological Alterations in the Fine Structure of Cellular and Extracellular Components

3rd Edition - November 25, 1988

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  • Author: Feroze N. Ghadially
  • eBook ISBN: 9781483192086

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Ultrastructural Pathology of the Cell and Matrix: Third Edition Volume I present a comprehensive examination of the intracellular lesion. It discusses the analysis of pathological tissues using electron microscope. It addresses the experimental procedures made on the cellular level. Some of the topics covered in the book are the physiological analysis of the nucleus; nuclear matrix, interchromatin, and perichromatin granules; structure and function of centrioles; characteristics of mitochondria; Golgi complex in cell differentiation and neoplasia; and degranulation of rough endoplasmic reticulum. The intracytoplasmic and intranuclear annulate lamellae are fully covered. An in-depth account of the classification, history, and nomenclature of lysosomes are provided. The morphology and normal variations of melanosomes and anchoring fibrils are completely presented. A chapter is devoted to the endocytotic structures and cell processes. Another section focuses on the classification and nomenclature of fibrous components. The book can provide useful information to cytologists, scientists, students, and researchers.

Table of Contents

  • Preface to the Third Edition

    Preface to the Second Edition

    Preface to the First Edition


    1 Nucleus


    Nuclear Shape

    Cerebriform Nucleus

    Radially Segmented Nucleus

    Chromatin in Normal, Neoplastic and Necrotic Cells

    The Nuclear Matrix and Interchromatin and Perichromatin Granules

    Giant Perichromatin Granules

    Nuclear Envelope and Pores

    Thickening, Proliferation and Reduplication of Nuclear Envelope

    Evaginations or Blebs of Nuclear Envelope

    Nuclear Fibrous Lamina

    Nucleolus, Structure and Variations in Size, Shape and Numbers

    Meandering Nucleolus

    Nucleolar Margination

    Segregation of Nucleolar Components

    Pseudoinclusions and True Inclusions

    Intranuclear Russell Bodies

    Intranuclear Concentric Laminated Inclusions

    Intranuclear Helioid Inclusions

    Intranuclear Membranous Lamellae, Tubules and Vesicles

    Intranucleolar Membranous Lamellae, Tubules and Vesicles

    Intranuclear Glygogen Inclusions

    Intranuclear Lipid Inclusions

    Intranuclear Filamentous and Crystalline Inclusions

    Intranuclear Haemoglobin Inclusions

    Intranuclear Lead Inclusions

    Intranuclear Bismuth Inclusions

    Intranuclear Viral Inclusions and Virus-like Particles

    Nuclear Projections, Pockets, Loops, Satellites and Clefts

    Nuclear Bodies


    2 Centrioles


    Structure and Function


    3 Mitochondria


    Mitochondrial Morphology and Enzyme Content

    Concentration of Cristae

    Lamellar, Tubular and Vesicular Cristae

    Concentric Cristae

    Zig-Zag Cristae

    Fenestrated Cristae

    Longitudinally Orientated Cristae

    Prismatic Cristae

    Sinuous Undulating and Reticular Cristae


    Mitochondrial Involution and Elimination

    Mitochondrial Associations

    Intermitochondrial Herniations, Whorls and Bridges

    Variations in Dense Granules and Calcification

    Swollen or Hydropic Mitochondria

    Flocculent or Woolly Densities in Mitochondria

    Mitochondrial Hypertrophy and Hyperplasia

    Mitochondria in Oncocytes and Oncocytomas

    Giant Mitochondria

    Ring-Shaped and Cup-Shaped Mitochondria


    Mitochondrial Changes in Neoplasia

    Intramitochondrial Glycogen Inclusions

    Intramitochondrial Lipidic Inclusions

    Intramitochondrial Crystalline, Paracrystalline and Filamentous Inclusions

    Intramitochondrial Iron Inclusions


    4 Golgi Complex and Secretory Granules


    Structure and Function

    Golgi Complex in Cell Differentiation and Neoplasia

    Hypertrophy and Atrophy of Golgi Complex

    Lipid and Lipoprotein in Golgi Complex

    Mucous Granules in Normal and Neoplastic Cells

    Serous and Zymogen Granules in Normal and Neoplastic Cells

    Secretory Granules (Myelinosomes) in Normal and Neoplastic Type II Alveolar Cells

    Neuroendocrine (APUD) Granules and Uranaffin Reaction in Normal and Neoplastic Cells

    Neuroendocrine Granules in Normal and Neoplastic Pancreatic Neuroendocrine Cells

    Neuroendocrine Granules in Carcinoids

    Adrenaline and Noradrenaline Granules in Normal and Neoplastic Cells

    Misplaced Exocytosis

    Amphicrine Cells and Amphicrine Tumours

    Granules of Mast Cells and Basophilic Leucocytes


    5 Endoplasmic Reticulum


    Rough Endoplasmic Reticulum

    Smooth Endoplasmic Reticulum

    Dilatation and Vesiculation of Endoplasmic Reticulum Due to Ingress of Water

    Dilatation and Vesiculation of Rough Endoplasmic Reticulum Due to Storage of Secretory Products

    Degranulation of Rough Endoplasmic Reticulum

    Disaggregation of Polyribosomes

    Helical Polyribosomes and Ribosome Crystals

    Ribosome-Lamella Complex

    Endoplasmic Reticulum and Ribosomes in Cell Differentiation and Neoplasia

    Hypertrophy of Rough Endoplasmic Reticulum

    Hypertrophy of Smooth Endoplasmic Reticulum in Hepatocytes

    Confronting Cisternae

    Tubular Confronting Cisternae

    Confronting Cisternae Complex

    Tubule Group: Rough and Smooth Tubular Aggregates and Intracisternal Tubules

    Microtubule Group: Ordered Arrays of Straight Microtubules and Randomly Oriented Microtubules in Rough Endoplasmic Reticulum

    Microtubule Group: Parallel Microtubular Arrays

    Microtubule Group: Microtubuloreticular Structures (Lupus Type and Others)

    Membrane Group: Reticulated, Knotted, Undulating, Pouched, Radiate and Cross-Banded Membranous Formations or Complexes

    Membrane Group: Concentric Membranous Bodies of the Endoplasmic Reticulum

    Glycogen in Rough Endoplasmic Reticulum

    Lipid in Endoplasmic Reticulum (Liposomes)

    Proteinaceous Granules and Crystalline Inclusions in Rough Endoplasmic Reticulum

    Laminated Inclusions in Rough Endoplasmic Reticulum

    Intracisternal Sequestration

    Virus in Endoplasmic Reticulum


    6 Annulate Lamellae


    Intracytoplasmic and Intranuclear Annulate Lamellae


    7 Lysosomes

    Introduction (History, Classification and Nomenclature)

    Heterolysosomes and Autolysosomes

    Lamellar Cup-Shaped Lysosomes

    Multivesicular Bodies and R-Bodies

    Lipofuscin (Residual Bodies)

    Myelinoid Membranes, Myelin Figures and Myelinosomes

    Erythrophagosomes and Erythrophagolysosomes

    Siderosomes, Haemosiderin and Ferritin

    Lysosomes and Residual Bodies in Tumors

    Lysosomes in Erythrocytes

    Lysosomes in Neutrophil Leucocytes

    Lysosomes in Eosinophil Leucocytes

    Lysosomes in Monocytes and Macrophages

    Lysosomes in Melanosis Coli and Some Other Melanoses

    Lysosomes in Melanosis Duodeni

    Lysosomes in Malakoplakia

    Lysosomes in Granular Cell Tumors

    Lysosomes in Rheumatoid Arthritis

    Lysosomes in the Liver of the Tumor-Bearing Host

    Angulate Lysosomes

    Lysosomes in Mucopolysaccharidoses

    Lysosomes in Metachromatic Leucodystrophy (Sulphatoidosis)

    Curvilinear Bodies in Lysosomes

    Collagen in Lysosomes

    Glycogen in Lysosomes (Glycogenosomes)

    Metals in Lysosomes



    Interlysosomal Crystalline Plates (Zipper-like Structures)


    8 Microbodies (Peroxisomes, Microperoxisomes and Catalosomes)


    Structure and Normal Variations

    Pathological Variations in Size, Shape and Numbers


    9 Melanosomes


    Morphology and Normal Variations

    Alterations in Melanosomes in Melanomas and Pigmentary Disorders

    Granular Melanosomes

    Balloon Melanosomes

    Giant Melanosomes

    Melanosome-Producing and Melanosome-Containing Cells in Tumors


    10 Rod-Shaped Microtubulated Bodies


    Structure, Distribution and Variations

    Rod-Shaped Microtubulated Body in Vasoformative Tumors


    11 Intracytoplasmic Filaments


    Myofilaments in Striated Muscle

    Ring Fibers

    Myofibrillary Degeneration

    Morphological Alterations of the Z-Line

    Myofilaments in Rhabdomyoma and Rhabdomyosarcoma

    Myofilaments in Smooth Muscle

    Myofilaments in Leiomyoma and Leiomyosarcoma

    Myofilaments in Cells Other than Muscle

    Myofibroblasts and Myofibroblastoma

    Intermediate Filaments in Normal and Pathological States (including Neoplastic)

    Mallory's Bodies

    Globular Filamentous Bodies

    Crystals and Crystalloids of Intracytoplasmic Filaments

    Crystalline Filamentous Cylinders

    Asteroid Bodies


    12 Microtubules


    Structure, Function and Variations


    13 Cytoplasmic Matrix and Its Inclusions


    The Dark Cell-Light Cell Phenomenon

    Dark and Light Cells in Tumors


    Polyglucosan Bodies (Corpora Amylacea, Lafora's Bodies, Lafora-like Bodies, Bielschowsky's Bodies and Amylopectin Bodies)


    Crystalline Inclusions


    Heinz Bodies

    Porphyrin Inclusions

    Intracellular and Intracytoplasmic Collagen

    Intracytoplasmic Banded Structures

    Intracytoplasmic Desmosomes

    Intracytoplasmic Canaliculi and Lumina

    Intracytoplasmic Nucleolus-Like Bodies (Nematosome, Nuage, Dense Body, Honey-Comb Body, Ribosomal Body)

    Viral Inclusions


    14 Cell Membrane and Coat


    Cell Membrane

    T-Tubule Networks

    Basement Membrane and Basal Lamina

    Alterations in the Basal Lamina

    Basal Lamina in Alport's Syndrome

    Basal Lamina in Dense Deposit Disease

    Coat of Free Surfaces

    External Lamina

    Glycocalyceal Bodies and Filamentous Core Rootlets

    Spherical Microparticles

    Crystals in Basal Lamina (Striated Lamellar Structures, Fibrin and Others)


    15 Cell Junctions


    Structure and Function of Cell Junctions

    Alterations of Cell Junctions in Neoplasia

    Diagnostic Value of Cell Junctions in Tumors

    Cell Junctions in Connective Tissues and Haemopoietic Tissues


    16 Endocytotic Structures and Cell Processes


    Endocytotic Vesicles and Vacuoles

    Micropinocytosis Vermiformis

    Langerhans' Cell Granules (Birkbeck's Granules)


    Cytoplasmic Bubbling, Blebs and Blisters

    Microvilli and Stereocilia

    Morphological Alterations in Microvilli


    Cell Processes in Hairy Cell Leukaemia

    Ropalocytes and Ropalopodia

    Uropod of the Lymphocyte

    Foot Processes of Podocytes

    Cilia, Flagella and Sperm Tails

    Single, Primary or Oligocilia

    Atypical Cilia

    Atypical Basal Bodies (Half Centrioles, Giant Centrioles and Others)

    Immotile Cilia Syndrome


    17 Extracellular Matrix (Extracellular Components)

    Introduction (Classification and Nomenclature of Fibrous Components)

    Collagen, Filaments, Fibrils and Fibers

    Collagen in Fossils and Mummies

    Anchoring Fibrils

    Spiny Collagen

    Fibrous Long-Spacing Collagen

    Segment Long-Spacing Collagen

    Giant Collagen Fibrils and Amianthoid Fibers

    Spiraled Collagen (Poorly Packed Collagen and Frayed Collagen)

    Elastic Fibers, Elaunin Fibers and Oxytalan Fibers 1252

    Calcified Elastic Fibers



    Proteoglycan Particles (Matrix Granules)

    Calcification (Matrical Lipidic Debris, Matrix Vesicles, Calcifying Collagen and Calcifying Secretions)




Product details

  • No. of pages: 612
  • Language: English
  • Copyright: © Butterworth-Heinemann 1988
  • Published: November 25, 1988
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483192086

About the Author

Feroze N. Ghadially

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  • Euan M. Mon Dec 13 2021

    Ultrastructural Pathology of the Cell and Matrix 3rd Edition Vol 1

    Excellent detail and descriptions/photomicrographs. I had purchased Vol 2 in paperback, I wish I had also purchased it in the electronic version. Essential reference for any cell biologist/electron microscopist.