Ultrastructural Pathology of the Cell and Matrix

Preface to the Third EditionPreface to the Second EditionPreface to the First EditionAcknowledgments1 Nucleus Introduction Nuclear Shape Cerebriform Nucleus Radially Segmented Nucleus Chromatin in Normal, Neoplastic and Necrotic Cells The Nuclear Matrix and Interchromatin and Perichromatin Granules Giant Perichromatin Granules Nuclear Envelope and Pores Thickening, Proliferation and Reduplication of Nuclear Envelope Evaginations or Blebs of Nuclear Envelope Nuclear Fibrous Lamina Nucleolus, Structure and Variations in Size, Shape and Numbers Meandering Nucleolus Nucleolar Margination Segregation of Nucleolar Components Pseudoinclusions and True Inclusions Intranuclear Russell Bodies Intranuclear Concentric Laminated Inclusions Intranuclear Helioid Inclusions Intranuclear Membranous Lamellae, Tubules and Vesicles Intranucleolar Membranous Lamellae, Tubules and Vesicles Intranuclear Glygogen Inclusions Intranuclear Lipid Inclusions Intranuclear Filamentous and Crystalline Inclusions Intranuclear Haemoglobin Inclusions Intranuclear Lead Inclusions Intranuclear Bismuth Inclusions Intranuclear Viral Inclusions and Virus-like Particles Nuclear Projections, Pockets, Loops, Satellites and Clefts Nuclear Bodies References2 Centrioles Introduction Structure and Function References3 Mitochondria Introduction Mitochondrial Morphology and Enzyme Content Concentration of Cristae Lamellar, Tubular and Vesicular Cristae Concentric Cristae Zig-Zag Cristae Fenestrated Cristae Longitudinally Orientated Cristae Prismatic Cristae Sinuous Undulating and Reticular Cristae Mitochondriogenesis Mitochondrial Involution and Elimination Mitochondrial Associations Intermitochondrial Herniations, Whorls and Bridges Variations in Dense Granules and Calcification Swollen or Hydropic Mitochondria Flocculent or Woolly Densities in Mitochondria Mitochondrial Hypertrophy and Hyperplasia Mitochondria in Oncocytes and Oncocytomas Giant Mitochondria Ring-Shaped and Cup-Shaped Mitochondria Chondriospheres Mitochondrial Changes in Neoplasia Intramitochondrial Glycogen Inclusions Intramitochondrial Lipidic Inclusions Intramitochondrial Crystalline, Paracrystalline and Filamentous Inclusions Intramitochondrial Iron Inclusions References4 Golgi Complex and Secretory Granules Introduction Structure and Function Golgi Complex in Cell Differentiation and Neoplasia Hypertrophy and Atrophy of Golgi Complex Lipid and Lipoprotein in Golgi Complex Mucous Granules in Normal and Neoplastic Cells Serous and Zymogen Granules in Normal and Neoplastic Cells Secretory Granules (Myelinosomes) in Normal and Neoplastic Type II Alveolar Cells Neuroendocrine (APUD) Granules and Uranaffin Reaction in Normal and Neoplastic Cells Neuroendocrine Granules in Normal and Neoplastic Pancreatic Neuroendocrine Cells Neuroendocrine Granules in Carcinoids Adrenaline and Noradrenaline Granules in Normal and Neoplastic Cells Misplaced Exocytosis Amphicrine Cells and Amphicrine Tumours Granules of Mast Cells and Basophilic Leucocytes References5 Endoplasmic Reticulum Introduction Rough Endoplasmic Reticulum Smooth Endoplasmic Reticulum Dilatation and Vesiculation of Endoplasmic Reticulum Due to Ingress of Water Dilatation and Vesiculation of Rough Endoplasmic Reticulum Due to Storage of Secretory Products Degranulation of Rough Endoplasmic Reticulum Disaggregation of Polyribosomes Helical Polyribosomes and Ribosome Crystals Ribosome-Lamella Complex Endoplasmic Reticulum and Ribosomes in Cell Differentiation and Neoplasia Hypertrophy of Rough Endoplasmic Reticulum Hypertrophy of Smooth Endoplasmic Reticulum in Hepatocytes Confronting Cisternae Tubular Confronting Cisternae Confronting Cisternae Complex Tubule Group: Rough and Smooth Tubular Aggregates and Intracisternal Tubules Microtubule Group: Ordered Arrays of Straight Microtubules and Randomly Oriented Microtubules in Rough Endoplasmic Reticulum Microtubule Group: Parallel Microtubular Arrays Microtubule Group: Microtubuloreticular Structures (Lupus Type and Others) Membrane Group: Reticulated, Knotted, Undulating, Pouched, Radiate and Cross-Banded Membranous Formations or Complexes Membrane Group: Concentric Membranous Bodies of the Endoplasmic Reticulum Glycogen in Rough Endoplasmic Reticulum Lipid in Endoplasmic Reticulum (Liposomes) Proteinaceous Granules and Crystalline Inclusions in Rough Endoplasmic Reticulum Laminated Inclusions in Rough Endoplasmic Reticulum Intracisternal Sequestration Virus in Endoplasmic Reticulum References6 Annulate Lamellae Introduction Intracytoplasmic and Intranuclear Annulate Lamellae References7 Lysosomes Introduction (History, Classification and Nomenclature) Heterolysosomes and Autolysosomes Lamellar Cup-Shaped Lysosomes Multivesicular Bodies and R-Bodies Lipofuscin (Residual Bodies) Myelinoid Membranes, Myelin Figures and Myelinosomes Erythrophagosomes and Erythrophagolysosomes Siderosomes, Haemosiderin and Ferritin Lysosomes and Residual Bodies in Tumors Lysosomes in Erythrocytes Lysosomes in Neutrophil Leucocytes Lysosomes in Eosinophil Leucocytes Lysosomes in Monocytes and Macrophages Lysosomes in Melanosis Coli and Some Other Melanoses Lysosomes in Melanosis Duodeni Lysosomes in Malakoplakia Lysosomes in Granular Cell Tumors Lysosomes in Rheumatoid Arthritis Lysosomes in the Liver of the Tumor-Bearing Host Angulate Lysosomes Lysosomes in Mucopolysaccharidoses Lysosomes in Metachromatic Leucodystrophy (Sulphatoidosis) Curvilinear Bodies in Lysosomes Collagen in Lysosomes Glycogen in Lysosomes (Glycogenosomes) Metals in Lysosomes Aurosomes Platinosomes Interlysosomal Crystalline Plates (Zipper-like Structures) References8 Microbodies (Peroxisomes, Microperoxisomes and Catalosomes) Introduction Structure and Normal Variations Pathological Variations in Size, Shape and Numbers References9 Melanosomes Introduction Morphology and Normal Variations Alterations in Melanosomes in Melanomas and Pigmentary Disorders Granular Melanosomes Balloon Melanosomes Giant Melanosomes Melanosome-Producing and Melanosome-Containing Cells in Tumors References10 Rod-Shaped Microtubulated Bodies Introduction Structure, Distribution and Variations Rod-Shaped Microtubulated Body in Vasoformative Tumors References11 Intracytoplasmic Filaments Introduction Myofilaments in Striated Muscle Ring Fibers Myofibrillary Degeneration Morphological Alterations of the Z-Line Myofilaments in Rhabdomyoma and Rhabdomyosarcoma Myofilaments in Smooth Muscle Myofilaments in Leiomyoma and Leiomyosarcoma Myofilaments in Cells Other than Muscle Myofibroblasts and Myofibroblastoma Intermediate Filaments in Normal and Pathological States (including Neoplastic) Mallory's Bodies Globular Filamentous Bodies Crystals and Crystalloids of Intracytoplasmic Filaments Crystalline Filamentous Cylinders Asteroid Bodies References12 Microtubules Introduction Structure, Function and Variations References13 Cytoplasmic Matrix and Its Inclusions Introduction The Dark Cell-Light Cell Phenomenon Dark and Light Cells in Tumors Glycogen Polyglucosan Bodies (Corpora Amylacea, Lafora's Bodies, Lafora-like Bodies, Bielschowsky's Bodies and Amylopectin Bodies) Lipid Crystalline Inclusions Fibrin Heinz Bodies Porphyrin Inclusions Intracellular and Intracytoplasmic Collagen Intracytoplasmic Banded Structures Intracytoplasmic Desmosomes Intracytoplasmic Canaliculi and Lumina Intracytoplasmic Nucleolus-Like Bodies (Nematosome, Nuage, Dense Body, Honey-Comb Body, Ribosomal Body) Viral Inclusions References14 Cell Membrane and Coat Introduction Cell Membrane T-Tubule Networks Basement Membrane and Basal Lamina Alterations in the Basal Lamina Basal Lamina in Alport's Syndrome Basal Lamina in Dense Deposit Disease Coat of Free Surfaces External Lamina Glycocalyceal Bodies and Filamentous Core Rootlets Spherical Microparticles Crystals in Basal Lamina (Striated Lamellar Structures, Fibrin and Others) References15 Cell Junctions Introduction Structure and Function of Cell Junctions Alterations of Cell Junctions in Neoplasia Diagnostic Value of Cell Junctions in Tumors Cell Junctions in Connective Tissues and Haemopoietic Tissues References16 Endocytotic Structures and Cell Processes Introduction Endocytotic Vesicles and Vacuoles Micropinocytosis Vermiformis Langerhans' Cell Granules (Birkbeck's Granules) Emperipolesis Cytoplasmic Bubbling, Blebs and Blisters Microvilli and Stereocilia Morphological Alterations in Microvilli Vermipodia Cell Processes in Hairy Cell Leukaemia Ropalocytes and Ropalopodia Uropod of the Lymphocyte Foot Processes of Podocytes Cilia, Flagella and Sperm Tails Single, Primary or Oligocilia Atypical Cilia Atypical Basal Bodies (Half Centrioles, Giant Centrioles and Others) Immotile Cilia Syndrome References17 Extracellular Matrix (Extracellular Components) Introduction (Classification and Nomenclature of Fibrous Components) Collagen, Filaments, Fibrils and Fibers Collagen in Fossils and Mummies Anchoring Fibrils Spiny Collagen Fibrous Long-Spacing Collagen Segment Long-Spacing Collagen Giant Collagen Fibrils and Amianthoid Fibers Spiraled Collagen (Poorly Packed Collagen and Frayed Collagen) Elastic Fibers, Elaunin Fibers and Oxytalan Fibers 1252 Calcified Elastic Fibers Amyloid Fibrin Proteoglycan Particles (Matrix Granules) Calcification (Matrical Lipidic Debris, Matrix Vesicles, Calcifying Collagen and Calcifying Secretions) ReferencesNomogramIndex