Tunneling in Biological Systems

Tunneling in Biological Systems

A Colloquium of the Johnson Research Foundation

1st Edition - January 28, 1979

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  • Editors: Britton Chance, Don Charles Devault, Hans Frauenfelder
  • eBook ISBN: 9781483271347

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Tunneling in Biological Systems focuses on the low temperature electron transport that reveals a quantum-mechanical effect called “tunneling.” This book discusses the tunneling in physical systems; detection of molecular vibrations with electron tunneling; chemical-rate theory of small-polaron hopping; and experimental approaches to electronic coupling in metal ion redox systems. The Faraday rotation and photoconductivity of photosynthetic structures at microwave frequencies; dynamics of electron transport in macromolecules; and electron transfer reactions in cytochrome oxidase are also elaborated. This text likewise covers the kinetic evidence for electron tunneling in solution; specificity and control in biological systems; molecular tunneling in heme proteins; and ligand binding. This publication is valuable to students and researchers interested in the physics of biological and medical problems.

Table of Contents

  • List of Contributors


    Tunneling in Physical Systems

    My Tunneling Experiences

    Introductory Comments

    Tunneling in Physical Systems


    Concepts in Quantum Mechanical Tunneling in Systems of Biological and Chemical Interest


    Detection of Molecular Vibrations with Electron Tunneling

    Tunneling in Network Models of Molecular Chains

    Localized and Delocalized Tunneling States

    General Discussion: Formulations of Theory

    Tunneling in Chemical Systems

    Electron and Nuclear Tunneling in Chemical and Biological Systems


    Chemical-Rate Theory of Small-Polaron Hopping


    A General Theoretical Approach to Tunneling Transfer and Dissociation

    A Quantum Theory of Low-Temperature Chemical and Biological Rate Processes in Condensed Media

    Experimental Approaches to Electronic Coupling in Metal Ion Redox Systems


    Electron Transfer Reactions of Metal Complexes in Solution


    Electron Transfer Properties of the Imidazolate Anion

    Electron Transfer in (NH3)5Ru(III)-4-Alkylpyridine- Cu(I) Binuclear Ions

    Electron Tunneling after Radiolysis


    Tunneling Distances and Exothermic Rate Restrictions in Electron Transfer Reactions

    General Discussion: Electron vs. Nuclear Tunneling

    General Discussion: Adiabaticity

    Tunneling in Biological Systems

    Introduction to Biological Aspects

    Tunneling in Photosynthetic Systems

    Cytochrome-Reaction Center-Quinone Interactions: Models for Biological Electron Transfer


    Electron Transfer between c-Type Cytochromes and High Potential Iron-Sulfur Proteins

    An Application of Electron Transfer Theory to a Problem in Chloroplast Membrane Topography

    Electron Tunneling in Photosystem-I Charge Recombination at Low Temperatures

    Some Data of Possible Relevance to Tunneling and Photosynthetic Reaction Centers


    The Effects of High Hydrostatic Pressure on Light-Induced Electron Transfer and Proton Binding in Chromatium


    Faraday Rotation and Photoconductivity of Photosynthetic Structures at Microwave Frequencies

    Nonadiabatic Electron Tunneling: Implications for Bacterial Photosynthesis and for Critical Physical Tests of the Mechanism


    Dynamics of Electron Transport in Macromolecules

    General Discussion: Temperature Dependence

    Tunneling in the Respiratory Chain

    Mitochondrial Electron Transfer at Phosphorylation Sites 2 and 3


    Electron Transport in the Succinate-Ubiquinone Segment of the Respiratory Chain

    Electron Transfer Reactions in Cytochrome Oxidase


    Definition of the Surface of Cytochrome c Interacting with Cytochrome Oxidase

    Structure/Function Relationships in Biological Electron Transport Proteins


    General Discussion: Cytochrome c and Some Other Biological Redox Molecules

    Tunneling in Model Biological Systems

    Conformational Distribution and Vibronic Coupling in the Blue Copper-Containing Protein Azurin

    Overall Charge Control of the Ionic Strength Effects upon the Redox Kinetics of Small Molecule-Protein and Protein-Protein Reactions

    the Energy Transforming Function Associated with Electron Transfer Reactions in Biological Systems

    Kinetic Evidence for Electron Tunneling in Solution

    Fermi-Level Matching: A Possible Condition in Redox Enzyme Specificity

    General Discussion: Distances

    Specificity and Control in Biological Systems

    General Discussion: Biological Specificity and Control

    Molecular Tunneling

    Molecular Tunneling in Heme Proteins


    Heme Ligand Configuration in Photodissociable Ferrous Myoglobin Complexes


    General Discussion: Ligand Binding

    Quantum Chemical Reactivity Near Absolute Zero: Biological, Chemical, and Astrophysical Aspects


    Experimental Approaches

    New Methods for Exploring Tunneling Phenomena


    General Discussion: Experimental Techniques

    Magnetic Interactions and Electron Transfer Kinetics of the Reduced Intermediate Acceptor in Reaction Centers (RCs) of Rhodopseudomonas Sphaeroides R-26. Evidence for Thermally Induced Tunneling

    Subject Index

Product details

  • No. of pages: 776
  • Language: English
  • Copyright: © Academic Press 1979
  • Published: January 28, 1979
  • Imprint: Academic Press
  • eBook ISBN: 9781483271347

About the Editors

Britton Chance

Don Charles Devault

Hans Frauenfelder

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