
Tumor Immunology
Description
Key Features
- Contributions from leading authorities
- Informs and updates on all the latest developments in the field
Readership
Table of Contents
Chapter One: Mouse Models of Tumor Immunotherapy
- Abstract
- 1 Introduction
- 2 Transplantable Tumor Models
- 3 Genetically Engineered Tumor Models
- 4 Carcinogen-Induced Tumor Models
- 5 Humanized Mouse Tumor Models
- 6 Perspectives
- 7 Materials and Methods
- Acknowledgments
Chapter Two: The Role of Neoantigens in Naturally Occurring and Therapeutically Induced Immune Responses to Cancer
- Abstract
- 1 Introduction
- 2 Cancer Immunoediting as an Encompassing Model of Immune System–Tumor Interactions
- 3 Antigenic Targets of Cancer Immunoediting
- 4 Setting the Groundwork: Genomic Approaches to Cancer Antigen Identification
- 5 Developing Cancer Immunotherapies Based on Genomic Identification of Tumor-Specific Neoantigens
- 6 Neoantigens as Therapeutic Targets in Human Cancer
- 7 Concluding Remarks
- Acknowledgments
Chapter Three: Tumor and Host Factors Controlling Antitumor Immunity and Efficacy of Cancer Immunotherapy
- Abstract
- 1 Rationale for Studying Regulation of the T Cell-Inflamed Tumor Microenvironment Phenotype
- 2 Molecular and Cellular Drivers of the T Cell-Inflamed Tumor Microenvironment
- 3 Tumor-Intrinsic Oncogene Pathways Mediating the Non-T Cell-Inflamed Tumor Microenvironment
- 4 Environmental Factors Influencing the Tumor Microenvironment: The Host Microbiota
- 5 Germline Genetic Differences as an Additional Source of Interpatient Heterogeneity
- 6 Conclusions and Implications
Chapter Four: Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers
- Abstract
- 1 Introduction
- 2 The Immune Microenvironment of Different Cancer Subtypes
- 3 Classification of Tumors in the Era of Omic Techniques
- 4 The Tumor Microenvironment and the Molecularly Defined Subgroups of Human Cancers
- 5 Conclusions: From the Immune Contexture of Tumor Subgroups to Precision Medicine
- Acknowledgments
Chapter Five: Advances in Therapeutic Cancer Vaccines
- Abstract
- 1 Introduction
- 2 Cancer Antigens
- 3 Approaches to Cancer Vaccines: What We Have Learned
- 4 In Situ Vaccination
- 5 Engineering Approaches
- 6 Concluding Remarks
Chapter Six: Combinatorial Cancer Immunotherapies
- Abstract
- 1 Introduction
- 2 Combinations of Coinhibitory Checkpoints
- 3 Combinations with Costimulatory Checkpoints
- 4 Combinations with Other Molecules in the Tumor Microenvironment
- 5 Other Anticancer Treatment Modalities in Combination with T Cell Checkpoint Blockade
- 6 Conclusions
Chapter Seven: Adoptive T-Cell Therapy for Cancer
- Abstract
- 1 Identifying Tumor-Associated Antigens Recognized by T-Cells
- 2 Cell Therapy with Genetically Engineered T-Cells
- 3 Cell Therapy with TIL
- 4 Cell Therapy Targeting Mutated “Neoantigens”
- 5 The Future of ACT
Product details
- No. of pages: 332
- Language: English
- Copyright: © Academic Press 2016
- Published: February 24, 2016
- Imprint: Academic Press
- eBook ISBN: 9780128096550
- Hardcover ISBN: 9780128051566