Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics

Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics

1st Edition - November 9, 2021

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  • Editors: Rajkumar Rajendram, Victor Preedy, Vinood Patel, Colin Martin
  • eBook ISBN: 9780128202388
  • Paperback ISBN: 9780128202371

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Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics is an essential read for anyone working in pain management. The book addresses the onset of pain, the cause of the pain, and the administration of analgesia or anesthesia. The etiology of pain is complex and multi-factorial, which is made more complex with the use of analgesics and local or general anesthetics. This volume works to clarify all of the subjects pertinent to anesthesia and the brain, from their variety, modes of action, and adverse effects.

Key Features

  • Provides a broad range of topics related to the neuroscience of analgesics and anesthetics
  • Contains chapter abstracts, key facts, a dictionary of terms, and summary points to aid in understanding
  • Discusses anesthesia types, mechanisms of action and affiliated effects
  • Helps readers navigate key areas for research and further clinical recommendations


Neurologists, anesthesiologists, pharmacologists, physiologists, psychologists, doctors, health care workers and experts in behavior. Academic libraries that covers the neuroscience of pain, anesthetics and analgesics. Undergraduates, postgraduate, lecturers, academic professors, and graduate students and trainees in the basic sciences or clinical disciplines who have an interest in pain mechanisms, diagnosis and/or management

Table of Contents

  • I. Drugs and agents used in anesthesia and analgesia
    1. Anesthesia for malignant hyperthermia susceptible patients
    Helga Cristina Almeida da Silva, Calim Neder and Mariana Lima
    2. Use of dextran in regional anesthesia
    Masahiko Tsuchiya
    3. Intraperitoneal local anesthetic agents in the management of post-operative pain
    Karlin Sevensma
    4. Automatic control of anesthesia via different vital signs
    Jiann-Shing Shieh, Jerry Chen and Maysam F. Abbod
    5. Non-opioid based analgesia in otolaryngology
    Khanh K. Nguyen, Yohanan Kim and Anthony Sanchez

    II. Mechanisms of action of drugs
    6. Buprenorphine: mechanisms and applications
    Anuj Aggarwal and Albert Lin
    7. Caffeine usage in pain management
    Thomas Weiser
    8. Chloroprocaine: features and applications
    Alain Borgeat
    9. Clonidine: features and applications
    Renato Gomez and Magda Lourenço Fernandes
    10. An excursion into secondary pharmacology of fentanyls with potential implications for drug design: σ1 receptor
    Piotr F. J. Lipiński
    11. Isoflurane: mechanisms and applications
    Alexander Bautista
    12. The lidocaine patch: features and applications: post-thoracotomy pain and beyond
    Alfonso Fiorelli
    13. Memantine: features and application to chronic pain control
    Harsha Shanthanna
    14. Midazolam: Perioperative administration
    Joe C. Hong
    15. Intravenous paracetamol: features and applications
    Ristiawan Muji Laksono and Isngadi Ahmad Wagimin
    16. Prilocaine: mechanisms and applications
    Sreekantha Babu Jonnalagadda
    17. Sevoflurane: features and use in topical application for wound care
    Manuel Gerónimo-Pardo
    18. Tramadol as an analgesic
    Ayman M. Mahmoud

    III. Adverse effects, reactions and outcomes
    19. Long-term effects of anaesthesia on the brain: an update on neurotoxicity
    Rajkumar Rajendram
    20. Neuraxial labour analgesia and breast feeding
    Roberto Giorgio Maria F. Wetzl
    21. Mechanistic Overview of How Opioid Analgesics Promote Constipation
    Jesse Di Cello
    22. Cognitive-behavioral therapy for opioid use disorder and chronic pain
    Declan Barry
    23. Preoperative opioid and benzodiazepines: impact on adverse outcomes
    Martin Ingi Sigurdsson
    24. Anesthetics, Malignant hyperthermia syndrome and Kv7 channels
    Mariarosaria. Bucci, Valentina Vellecco, Antonio Mancini and Giuseppe Cirino
    25. Problems with epidural catheter
    Mustafa Kemal Arslantas
    26. Headache after neuroaxial blocks: a focus on combined-epidural anesthesia
    Reyhan Arslantas
    27. Liposomal bupivacaine, pain relief and adverse events
    Alparslan Turan
    28. Adverse events associate with analgesics: a focus on paracetamol use
    Grzegorz Porebski and Iwona Popiolek

    IV. Novel and non-pharmacological aspects and treatments
    29. Acronychia pedunculata leaves and usage in pain
    U G Chandrika and W. M. K. M. Ratnayake
    30. Adansonia digitata and use in neuropathic pain: prostaglandins and beyond
    Aboyeji Lukuman Oyewole, Abdulmusawwir Alli-Oluwafuyi, Abdulrazaq Nafiu and Aminu Imam
    31. Andrographis paniculata standardized extract (ParActin) and pain
    Rafael A. Burgos
    32. Capsaicin: features usage in diabetic neuropathic pain
    Kongkiat Kulkantrakorn
    33. Cola nitida and Pain reliefLawrence
    Dayo Adedayo
    34. Analgesic effects of Ephedra Herb extract and ephedrine alkaloids-free Ephedra Herb extract (EFE)
    Sumiko Hyuga, Shunsuke Nakamori, Yoshiaki Amakura, Masashi Hyuga, Nahoko Uchiyama, Yoshinori Kobayashi, Takashi Hakamatsuka, Yukihiro Goda, Hiroshi Odaguchi and Toshihiko Hanawa
    35. Euphorbia bicolor (Euphorbiaceae) Latex Phytochemicals and applications to analgesia
    Paramita Basu, Dayna Loyd Averitt and Camelia Maier Maier
    36. Pain relieving activity of muntingia calabura l.: elucidation of possible mechanisms of action and identification of responsible phytoconstituents
    Zainul Amiruddin Zakaria
    37. Resolving neuroinflammation and pain with Maresin 1, a specialized pro-resolving lipid mediator
    Waldiceu A. Verri Jr., Victor Fattori, Camila Ferraz, Fernanda Soares Rasquel-Oliveira, Tiago H. Zaninelli, Sergio Marques Borghi and Rubia Casagrande
    38. Therapeutic role of naringenin to alleviate inflammatory pain
    Waldiceu A. Verri Jr., marilia Fernandes manchope, Camila Ferraz, Sergio Marques Borghi, Fernanda Soares Rasquel-Oliveira, Anelise Franciosi, Julia Bagatim de Souza, Amanda Martins Dionisio and Rubia Casagrande
    39. Analgesic properties of Solanum paniculatum and S.torvum extracts
    Francisco José Roma Paumgartten
    40. Dietary constituents contribute to local anesthetic agent: neurophysiologicals mechanism of nociceptive pain
    Mamoru Takeda
    41. Pain response following prenatal stress and its modulation by antioxidants
    C B Abd Aziz
    42. Physical activity and fitness in the prevention of musculoskeletal pain in youth
    Fernando Estevez-Lopez, Pablo Molina-García Sr. and Patrocinio Ariza-Vega
    43. Linking aerobic exercise and childhood pain alleviation: a narrative
    C. Cushing
    44. Physical activity and exercise in the management of musculoskeletal pain: a focus on fibromyalgia
    Fernando Estevez-Lopez
    45. Spinal cord stimulation and limb pain
    Usman Latif and Timothy Sowder
    46. Effectiveness of neural mobilization on pain and disability in individuals with musculoskeletal disorders
    Carlos Romero Morales
    47. Virtual reality and applications to treating neck pain
    M. Razeghi
    48. Virtual reality-induced analgesia and dental pain
    Elitsa Veneva
    49. Vibrotactile devices, DentalVibe and local anesthesiaElitsa
    Veneva, Ani Belcheva and Ralitsa D. Raycheva
    50. Cooled radiofrequency ablation (CRFA) and osteoarthritis treatment for pain
    Antonia Chen and Eric Moorhead
    51. Non-pharmacologic analgesic therapies: a focus on photobiomodulation, acustimulation and cryoanalgesia (ice) therapy
    Roya Yumul, Ofelia Loani Elvir Lazo and Paul Frederick White
    52. New coping strategies and self-education for chronic pain management: e-health
    Victoria Mazoteras Pardo, Marta San-Antolín, Daniel López-López, Ricardo Becerro-de-Bengoa-Vallejo, Marta Losa-Iglesias, Carlos Romero Morales, David Rodríguez-Sanz, Eva María Martinez-Jiménez and César Calvo-Lobo Sr.
    53. Postoperative Pain Management Truncal blocks in obstetric and gynecologic surgery
    Pelin Corman Dincer

Product details

  • No. of pages: 680
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: November 9, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128202388
  • Paperback ISBN: 9780128202371

About the Editors

Rajkumar Rajendram

Dr. Rajendram is a clinician scientist whose focus is on perioperative medicine, anesthesia, and intensive care. He graduated in 2001 with a distinction from Guy’s, King’s, and St. Thomas Medical School in London, and began his postgraduate medical training in general medicine and intensive care in Oxford. Dr. Rajendram returned to Oxford as a consultant in general medicine at the John Radcliffe Hospital, Oxford, before moving to the Royal Free London Hospitals as a consultant in intensive care, anesthesia, and perioperative medicine. He is currently a consultant in internal and perioperative medicine at King Abdulaziz Medical City, Riyadh, Saudi Arabia. As a visiting lecturer in the Division of Diabetes and Nutritional Sciences, King’s College London, he has published over 100 textbook chapters, review articles, peer-reviewed papers, and abstracts.

Affiliations and Expertise

Visiting Lecturer, Division of Diabetes and Nutritional Sciences, King’s College London, UK

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is Emeritus Professor of Nutritional Biochemistry, at King’s College London and Professor of Clinical Biochemistry (Hon) at King’s College Hospital. He was the long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has carried out research when attached to Imperial College London, The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. Prof. Preedy is a leading expert on the science of health and has a long-standing interest in dietary and plant-based components. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Emeritus Professor, King’s College London; Professor, King’s College Hospital, London, UK

Vinood Patel

Vinood B. Patel, BSc, PhD, FRSC, is currently Reader in Clinical Biochemistry at the University of Westminster. He presently directs studies on metabolic pathways involved in liver disease, particularly related to mitochondrial energy regulation and cell death. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the pathophysiology of liver disease. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of liver disease and understanding mitochondrial oxidative stress in Alzheimer’s disease and gastrointestinal dysfunction in autism. Dr Patel is a nationally and internationally recognized researcher and has several edited biomedical books related to the use or investigation of active agents or components. In 2014 Dr. Patel was elected as a Fellow to The Royal Society of Chemistry.

Affiliations and Expertise

Reader, University of Westminster, London, UK

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

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