Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics

1st Edition - November 9, 2021
Editors: Rajkumar Rajendram, Victor R Preedy, Vinood Patel, Colin R Martin
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 0 2 3 7 - 1
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 0 2 3 8 - 8

Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics is an essential read for anyone working in pain management. The book addresses the onset of pain, the… Read more

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Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics is an essential read for anyone working in pain management. The book addresses the onset of pain, the cause of the pain, and the administration of analgesia or anesthesia. The etiology of pain is complex and multi-factorial, which is made more complex with the use of analgesics and local or general anesthetics. This volume works to clarify all of the subjects pertinent to anesthesia and the brain, from their variety, modes of action, and adverse effects.

I. Drugs and agents used in anesthesia and analgesia

1. Anesthesia for malignant hyperthermia susceptible patients
Helga Cristina Almeida da Silva, Calim Neder and Mariana Lima

2. Use of dextran in regional anesthesia
Masahiko Tsuchiya

3. Intraperitoneal local anesthetic agents in the management of post-operative pain
Karlin Sevensma

4. Automatic control of anesthesia via different vital signs
Jiann-Shing Shieh, Jerry Chen and Maysam F. Abbod

5. Non-opioid based analgesia in otolaryngology
Khanh K. Nguyen, Yohanan Kim and Anthony Sanchez

II. Mechanisms of action of drugs

6. Buprenorphine: mechanisms and applications
Anuj Aggarwal and Albert Lin

7. Caffeine usage in pain management
Thomas Weiser

8. Chloroprocaine: features and applications
Alain Borgeat

9. Clonidine: features and applications
Renato Gomez and Magda Lourenço Fernandes

10. An excursion into secondary pharmacology of fentanyls with potential implications for drug design: σ1 receptor
Piotr F. J. Lipiński

11. Isoflurane: mechanisms and applications
Alexander Bautista

12. The lidocaine patch: features and applications: post-thoracotomy pain and beyond
Alfonso Fiorelli

13. Memantine: features and application to chronic pain control
Harsha Shanthanna

14. Midazolam: Perioperative administration
Joe C. Hong

15. Intravenous paracetamol: features and applications
Ristiawan Muji Laksono and Isngadi Ahmad Wagimin

16. Prilocaine: mechanisms and applications
Sreekantha Babu Jonnalagadda

17. Sevoflurane: features and use in topical application for wound care
Manuel Gerónimo-Pardo

18. Tramadol as an analgesic
Ayman M. Mahmoud

III. Adverse effects, reactions and outcomes

19. Long-term effects of anaesthesia on the brain: an update on neurotoxicity
Rajkumar Rajendram

20. Neuraxial labour analgesia and breast feeding
Roberto Giorgio Maria F. Wetzl

21. Mechanistic Overview of How Opioid Analgesics Promote Constipation
Jesse Di Cello

22. Cognitive-behavioral therapy for opioid use disorder and chronic pain
Declan Barry

23. Preoperative opioid and benzodiazepines: impact on adverse outcomes
Martin Ingi Sigurdsson

24. Anesthetics, Malignant hyperthermia syndrome and Kv7 channels
Mariarosaria. Bucci, Valentina Vellecco, Antonio Mancini and Giuseppe Cirino

25. Problems with epidural catheter
Mustafa Kemal Arslantas

26. Headache after neuroaxial blocks: a focus on combined-epidural anesthesia
Reyhan Arslantas

27. Liposomal bupivacaine, pain relief and adverse events
Alparslan Turan

28. Adverse events associate with analgesics: a focus on paracetamol use
Grzegorz Porebski and Iwona Popiolek

IV. Novel and non-pharmacological aspects and treatments

29. Acronychia pedunculata leaves and usage in pain
U G Chandrika and W. M. K. M. Ratnayake

30. Adansonia digitata and use in neuropathic pain: prostaglandins and beyond
Aboyeji Lukuman Oyewole, Abdulmusawwir Alli-Oluwafuyi, Abdulrazaq Nafiu and Aminu Imam

31. Andrographis paniculata standardized extract (ParActin) and pain
Rafael A. Burgos

32. Capsaicin: features usage in diabetic neuropathic pain
Kongkiat Kulkantrakorn

33. Cola nitida and Pain reliefLawrence
Dayo Adedayo

34. Analgesic effects of Ephedra Herb extract and ephedrine alkaloids-free Ephedra Herb extract (EFE)
Sumiko Hyuga, Shunsuke Nakamori, Yoshiaki Amakura, Masashi Hyuga, Nahoko Uchiyama, Yoshinori Kobayashi, Takashi Hakamatsuka, Yukihiro Goda, Hiroshi Odaguchi and Toshihiko Hanawa

35. Euphorbia bicolor (Euphorbiaceae) Latex Phytochemicals and applications to analgesia
Paramita Basu, Dayna Loyd Averitt and Camelia Maier Maier

36. Pain relieving activity of muntingia calabura l.: elucidation of possible mechanisms of action and identification of responsible phytoconstituents
Zainul Amiruddin Zakaria

37. Resolving neuroinflammation and pain with Maresin 1, a specialized pro-resolving lipid mediator
Waldiceu A. Verri Jr., Victor Fattori, Camila Ferraz, Fernanda Soares Rasquel-Oliveira, Tiago H. Zaninelli, Sergio Marques Borghi and Rubia Casagrande

38. Therapeutic role of naringenin to alleviate inflammatory pain
Waldiceu A. Verri Jr., marilia Fernandes manchope, Camila Ferraz, Sergio Marques Borghi, Fernanda Soares Rasquel-Oliveira, Anelise Franciosi, Julia Bagatim de Souza, Amanda Martins Dionisio and Rubia Casagrande

39. Analgesic properties of Solanum paniculatum and S.torvum extracts
Francisco José Roma Paumgartten

40. Dietary constituents contribute to local anesthetic agent: neurophysiologicals mechanism of nociceptive pain
Mamoru Takeda

41. Pain response following prenatal stress and its modulation by antioxidants
C B Abd Aziz

42. Physical activity and fitness in the prevention of musculoskeletal pain in youth
Fernando Estevez-Lopez, Pablo Molina-García Sr. and Patrocinio Ariza-Vega

43. Linking aerobic exercise and childhood pain alleviation: a narrative
C. Cushing

44. Physical activity and exercise in the management of musculoskeletal pain: a focus on fibromyalgia
Fernando Estevez-Lopez

45. Spinal cord stimulation and limb pain
Usman Latif and Timothy Sowder

46. Effectiveness of neural mobilization on pain and disability in individuals with musculoskeletal disorders
Carlos Romero Morales

47. Virtual reality and applications to treating neck pain
M. Razeghi

48. Virtual reality-induced analgesia and dental pain
Elitsa Veneva

49. Vibrotactile devices, DentalVibe and local anesthesiaElitsa
Veneva, Ani Belcheva and Ralitsa D. Raycheva

50. Cooled radiofrequency ablation (CRFA) and osteoarthritis treatment for pain
Antonia Chen and Eric Moorhead

51. Non-pharmacologic analgesic therapies: a focus on photobiomodulation, acustimulation and cryoanalgesia (ice) therapy
Roya Yumul, Ofelia Loani Elvir Lazo and Paul Frederick White

52. New coping strategies and self-education for chronic pain management: e-health
Victoria Mazoteras Pardo, Marta San-Antolín, Daniel López-López, Ricardo Becerro-de-Bengoa-Vallejo, Marta Losa-Iglesias, Carlos Romero Morales, David Rodríguez-Sanz, Eva María Martinez-Jiménez and César Calvo-Lobo Sr.

53. Postoperative Pain Management Truncal blocks in obstetric and gynecologic surgery
Pelin Corman Dincer

Rajkumar Rajendram

Dr Rajkumar Rajendram is a clinician scientist with a focus on internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St. Thomas Medical School, King’s College London in 2001. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram subsequently practiced as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford.

Dr Rajendram also trained in anaesthesia and intensive care in London and was awarded a fellowship of the Royal College of Anaesthetists (FRCA) in 2009. He completed advanced training in regional anaesthesia and intensive care. He was awarded a fellowship of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014. He then moved to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He has been a fellow of the Royal College of Physicians of Edinburgh (FRCP Edin) and the Royal College of Physicians of London (FRCP Lond) since 2017 and 2019 respectively. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.

Dr Rajendram’s focus on improving outcomes from Coronavirus Disease 2019 (COVID-19) has involved research on point of care ultrasound and phenotypes of COVID-19. Dr Rajendram also recognises that nutritional support is a fundamental aspect of medical care. This is particularly important for patients with COVID-19. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is an affiliated member of the Nutritional Sciences Research Division of King’s College London and has published over 400 textbook chapters, review articles, peer-reviewed papers and abstracts.

Affiliations and expertise

Consultant in Internal Medicine, King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia

Victor R Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.

Affiliations and expertise

Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK Visiting Professor, University of Hull, UK

Vinood Patel

Vinood B. Patel, BSc, PhD, FRSC, is currently Professor in Clinical Biochemistry at the University of Westminster. In 2014 Dr Patel was elected as a Fellow to The Royal Society of Chemistry. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School, NC, USA studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the pathophysiology of liver disease. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding mitochondrial oxidative stress in neurological disorders and iron dysregulation in diabetes. Dr Patel is a nationally and internationally recognized researcher and has several edited biomedical books related to the use or investigation of active agents or components. These books include The Handbook of Nutrition, Diet, and Epigenetics, Branched Chain Amino Acids in Clinical Nutrition, Cancer: Oxidative Stress and Dietary Antioxidants, Toxicology: Oxidative Stress and Dietary Antioxidants, Molecular Nutrition: Vitamins, The Neuroscience of Pain, Cognitive Behavioural Therapy. He is Editor of the ten-volume series Biomarkers in Disease: Methods, Discoveries and Applications.

Affiliations and expertise

Reader, Clinical Biochemistry, University of Westminster, London, UK

Colin R Martin

Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.

Affiliations and expertise

Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK