Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. The focus of this book is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field.

Key Features

  • Provides a background to translational research and the use of brain imaging in neuropsychiatric disorders
  • Critical discussion of the potential and limitations of neuroimaging as a translational tool for identifying and validating biomarkers
  • Identifies cross species neurosystems and common endpoints necessary to help accelerate CNS drug discovery and development for the treatment of neuropsychiatric disorders
  • Features an accompanying website with additional images and text


Primary Market: Researchers in the biopharmaceutical industry and academic who actively work on CNS drug treatment studies, often found in molecular biology, pharmacology, neuroscience, and psychiatry departments drug delivery groups, as well as, researchers using animal models to study drug development and therapeutics.

Secondary Market: Graduate students, postdocs and professors at medical schools studying translational medicine.

Table of Contents



1.0 Introduction

2.0 Fundamentals of Neuroimaging

3.0 Translational Neuroimaging



Abbreviation List

Chapter 1. Neuroimaging Modalities: Description, Comparisons, Strengths, and Weaknesses

1.0 Introduction

2.0 Radiotracer Techniques

3.0 Electrophysiological Techniques

4.0 Magnetic Resonance Techniques

5.0 Advantages, Disadvantages, and Practical Considerations


Chapter 2. Magnetic Resonance Imaging as a Tool for Modeling Drug Treatment of CNS Disorders: Strengths and Weaknesses

1.0 Introduction

2.0 MRI

3.0 MRS

4.0 Bold fMRI

5.0 Arterial Spin Labeling of Blood Flow

6.0 Conclusions



Chapter 3. Small Animal Imaging as a Tool for Modeling CNS Disorders: Strengths and Weaknesses

1.0 Introduction

2.0 Setting Up and Imaging Awake Animals

3.0 Typical Study Designs

4.0 Summary



Chapter 4. Structural Magnetic Resonance Imaging as a Biomarker for the Diagnosis, Progression, and Treatment of Alzheimer Disease

1.0 Introduction

2.0 Functional Readout of Volumetric MRI

3.0 Correlation of Structural MRI with the Neuropathology of Alzheimer Disease

4.0 Prediction of Clinical Progression to Dementia

5.0 Structural MRI in Therapeutic Clinical Trials

6.0 Use of Structural MRI in a Regulatory Setting

7.0 Conclusions


Chapter 5. Positron Emission Tomography in Alzheimer Disease: Diagnosis and Use as Biomarker Endpoints

1.0 Introduction

2.0 Historical Perspective

3.0 Pet as a Biomarker for Alzheimer Disease


5.0 Amyloid Pet

6.0 Clinical Relevance of Amyloid Pet

7.0 Future Directions


No. of pages:
© 2012
Academic Press
Print ISBN:
Electronic ISBN:


"This book examines how neuroimaging can play a role in translational research by developing preclinical models and ultimately clinical studies for drug discovery.", October 17, 2013
"Researchers in imaging technology, neurology, and mental health sciences introduce fundamental concepts of neuroimaging, the various modalities being used, how it is being used to study central nervous system (CNS) disorders, and specifically how it is being used to discover and develop drugs for such disorders."--Reference & Research Book News, October 2013