Translational Interventional Radiology

Translational Interventional Radiology

1st Edition - February 1, 2023

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  • Editors: Adam Eltorai, Tao Liu, Rajat Chand, Sanjeeva Kalva
  • Paperback ISBN: 9780128230268

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Description

Translational Research Radiology covers the principles of evidence-based medicine, applying them to the design of translational investigations. The book's readers will fully understand important concepts including case-control study, prospective cohort study, randomized trial and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in interventional radiology, and know what is needed in collaboration. Further, this title is indispensable for grant writing and funding efforts for Medical Researchers or Interventional Radiologists who have had clinical idea but no knowledge on how to test them. The practical, straightforward approach helps the aspiring investigator navigate challenging considerations in study design and implementation. It provides valuable discussions of the critical appraisal of published studies in interventional radiology, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all types of evidence in patient care.

Key Features

  • Focuses on the principles of evidence-based medicine and applies these principles to the design of translational investigations within interventional radiology
  • Provides a practical, straightforward approach that helps investigators navigate challenging considerations in study design and implementation
  • Details discussions of the critical appraisal of published studies in interventional radiology, supporting evaluation with respect to measuring outcomes and making effective use of all types of evidence in patient care

Readership

Researchers interested in translating their research into clinical practice, Interventional Radiologists

Table of Contents

  • PART I: CONCEPT
    Introduction to clinical research: What is it? Why is it needed?
    The question: Types of research questions and how to develop them
    Study population: Who and why them?
    Outcome measurements: What data is being collected and why?

    PART II: STUDY TYPES
    Design principles: Hierarchy of study types
    Case series: Design, measures, classic example
    Case-control study: Design, measures, classic example
    Cohort study: Design, measures, classic example
    Cross-section study: Design, measures, classic example
    Clinical trials: Design, measures, classic example
    Meta-analysis: Design, measures, classic example
    Cost-effectiveness study: Design, measures, classic example
    Diagnostic test evaluation: Design, measures, classic example
    Reliability study: Design, measures, classic example
    Database studies: Design, measures, classic example
    Surveys and questionnaires: Design, measures, classic example
    Qualitative methods and mixed methods

    PART III: CLINICAL TRIALS
    Randomized control: Design, measures, classic example
    Nonrandomized control: Design, measures, classic example
    Historical control: Design, measures, classic example
    Cross-over: Design, measures, classic example
    Withdrawal studies: Design, measures, classic example
    Factorial design: Design, measures, classic example
    Group allocation: Design, measures, classic example
    Hybrid design: Design, measures, classic example
    Large, pragmatic: Design, measures, classic example
    Equivalence and noninferiority: Design, measures, classic example
    Adaptive: Design, measures, classic example
    Randomization: Fixed or adaptive procedures
    Blinding: Who and how?
    Multicenter considerations

    PART IV: PLANNING
    Optimizing the question: Balancing significance and feasibility
    Meaningful outcome measurements
    Sample size
    Budgeting
    Ethics and review boards
    Regulatory considerations for new drugs and devices
    Funding approaches
    Research team
    Subject recruitment
    Data management
    Quality control
    Report forms: Harm and Quality of Life
    Subject adherence
    Survival analysis
    Monitoring committee in clinical trials

    PART V: STATISTICAL PRINCIPLES
    Presenting data
    Common issues in analysis
    Basic statistical principles
    Distributions
    Hypotheses and error types
    Power
    Regression
    t-test
    Chi-square
    Analysis of variance
    Correlation
    Biases

Product details

  • No. of pages: 308
  • Language: English
  • Copyright: © Academic Press 2023
  • Published: February 1, 2023
  • Imprint: Academic Press
  • Paperback ISBN: 9780128230268

About the Editors

Adam Eltorai

Dr. Eltorai MD, PhD completed his graduate studies in Biomedical Engineering and Biotechnology along with his medical degree from Brown University.  He has invented several medical technologies (from immunotherapies to medical devices) and developed innovations from in vitro studies and animal work through randomized clinical trials. Dr. Eltorai has published over 200 scientific journal articles, abstracts, books, book chapters.

Affiliations and Expertise

Brown University Warren Alpert Medical School, Marlborough, MA, USA

Tao Liu

Dr Liu obtained his PhD in Biostatistics from the University of Pennsylvania. Dr Liu is Associate Professor of Biostatistics and Director of the Brown ARCH Data and Statistics Core. He also is a faculty member at the biostatistics core of the Lifespan/Boston/Brown Center for AIDS Research (CFAR), Brown Data Science Initiative (DSI), Advance-Clinical Translational Research (Advance-CTR) and an affiliated faculty member for the AMPATH Biostatistics and Data Program. His research interests are in the area of health data science and include clinical decision making, incomplete data problems, causal inference, diagnostic testing, and design of clinical trials.

Affiliations and Expertise

Associate Professor of Biostatistics and Director of the Brown ARCH Data and Statistics Core, Brown University, USA

Rajat Chand

Dr. Rajat Chand is an Early Specialization in Interventional Radiology (ESIR) Resident at the John H. Stroger, Jr. Hospital of Cook County in Chicago, Illinois, USA. He is currently an International Outreach Chair for the Society of Interventional Radiology – Resident, Fellow, and Student section. Prior to that, he was a Communications Chair for the Society of Interventional Radiology – Resident, Fellow, and Student section and a Pediatric Service Line Chair for the Society of Interventional Radiology – Resident, Fellow, and Student section.

Affiliations and Expertise

Early Specialization in Interventional Radiology (ESIR) Resident, John H. Stroger, Jr. Hospital of Cook County Chicago, IL, USA

Sanjeeva Kalva

Sanjeeva Kalva, MD is the chief of Interventional Radiology in the Department of Radiology at Massachusetts General Hospital. He is a world-renowned expert in minimally invasive approaches to treating liver cancer. Dr. Kalva trained as an interventional radiologist in India where he served on the faculty at Kovai Medical Center and Hospital in Coimbatore. In 2004, he completed a research fellowship at Harvard Medical School followed by a fellowship in vascular and interventional radiology at Massachusetts General Hospital. He served on the faculty at Harvard Medical School and Massachusetts General Hospital until 2013 when he became the chief of Interventional Radiology at UT Southwestern Medical Center in Dallas, Texas. Dr. Kalva has published multiple research papers and book chapters in the peer-reviewed literature. His research focuses on the effectiveness of minimally invasive procedures to treat liver cancer, venous thromoboembolism, portal hypertension, varicose veins and pulmonary vascular disease including arteriovenous malformations. Dr. Kalva has won several awards for his work in interventional radiology including the Outstanding Performance Award and the Dr. Athanasoulis Award for Excellence in Teaching, both at Massachusetts General Hospital. He is an active member of a number of professional associations including the Radiological Society of North America and the American College of Radiology and has also been named a fellow of the Society of Interventional Radiology.

Affiliations and Expertise

Assistant Professor of Radiology, Massachusetts General Hospital, Boston, Massachusettes, USA

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