Transgenerational Epigenetics

Transgenerational Epigenetics

2nd Edition - May 18, 2019

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  • Editor: Trygve Tollefsbol
  • eBook ISBN: 9780128167335
  • Paperback ISBN: 9780128163634

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Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the severity of disease before offspring are born. This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as are current debates and future directions for research.

Key Features

  • Presents a fully-updated and expanded release addressing transgenerational epigenetics, epigenetic mechanisms of gene regulation, and the role of epigenetics in human longevity and cancer
  • Examines the field from "bench-to-bedside", discussing basic science, disease management, current debates, and next steps in epigenetic research and drug discovery
  • Features chapter contributions from international experts


Clinician-scientists; Human Geneticists; Medical Geneticists; Researchers working in genetics, biology, molecular biology, pharmaceutical science, and clinical therapy; advanced undergraduate students, graduate students; pharmaceutical company and biotechnology researchers interested in drug development and therapies

Table of Contents

  • 1. Generational epigenetic inheritance

    SECTION I Definitions and history of generational epigenetic inheritance
    2. Definition of epigenetic transgenerational inheritance and biological impacts
    3. Historical perspective of transgenerational epigenetics

    SECTION II Germline epigenetics
    4. Epigenetic changes in the mammalian paternal germ line

    SECTION III Parental epigenetic inheritance
    5. Maternal epigenetic inheritance
    6. Paternal epigenetic inheritance

    SECTION IV Basic mechanisms/processes of epigenetic inheritance
    7. Towards the molecular mechanisms of transgenerational epigenetic inheritance: insights from transgenic mice
    8. Histone-mediated transgenerational epigenetics
    9. Heritable generational epigenetic effects through small noncoding RNA
    10. Long noncoding RNA and epigenetic inheritance

    SECTION V Model organisms
    11. Nonmammalian model organisms in epigenetic research:an overview
    12. Plant models of transgenerational epigenetic inheritance
    13. Epigenetics and heritable phenotypic variations in livestock
    14. Transgenerational epigenetic inheritance in insects

    SECTION VI Evolution of transgenerational epigenetics
    15. Evolutionary perspectives on transgenerational epigenetics
    16. Inheritance of epigenome variants across generations during evolution

    SECTION VII Environmental epigenetic effects on the offspring
    17. Transgenerational epigenetics of endocrine-disrupting chemicals in mammals
    18. Transgenerational effects of imprinting
    19. Epigenetic inheritance across multiple generations

    SECTION VIII Impact of transgenerational epigenetics on disease
    20. Transgenerational epigenetics, paternal obesity, and insulin resistance
    21. Epigenetic inheritance of type 2 diabetes

    SECTION IX Clinical significance of transgenerational epigenetics
    22. Clinical aspects of transgenerational epigenetics

Product details

  • No. of pages: 518
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: May 18, 2019
  • Imprint: Academic Press
  • eBook ISBN: 9780128167335
  • Paperback ISBN: 9780128163634

About the Series Volume Editor

Trygve Tollefsbol

Trygve Tollefsbol
Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.

Affiliations and Expertise

Distinguished Professor of Biology, University of Alabama at Birmingham, AL, USA

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