Transfusion Medicine and Hemostasis

Transfusion Medicine and Hemostasis

Clinical and Laboratory Aspects

1st Edition - June 8, 2009

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  • Editors: Beth H. Shaz, Christopher D. Hillyer, James Zimring, Thomas Abshire
  • eBook ISBN: 9780080922300

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Description

Transfusion Medicine and Hemostasis is a manual-style book that links transfusion medicine and hemostasis to laboratory methods and diagnostic tests engaged in routine and specialized coagulation laboratories. The book is divided into two main parts with chapters that are brief and readable. The first main part of the book is subdivided into blood banking and transfusion medicine. Under blood banking, the chapters cover blood collection, donation process, component manufacturing, donor testing and storage; transfusion-medicine chapters examine the components for transfusion, pre-transfusion immunohematology testing, blood groups, blood products and their modifications, approaches to transfusion therapy in specific clinical settings, and transfusion reactions and complications. In addition, chapters that talk about apheresis, cellular therapy, and tissue banking in the hospital setting are included. Hemostasis, the second main part of the book, is subdivided into three sections. The first section, clinical coagulation, includes chapters about neonatal thrombocytopenia, inherited platelet function disorders, immune thrombocytopenia, immune-mediated coagulopathies, congenital bleeding disorders, and acquired bleeding disorders. The second section relates to laboratory testing of coagulation, with chapters about laboratory assessments of platelet disorders, von Willebrand disease, coagulation factor disorders, fibrinogen and fibrinolysis, tests for hypercoagulable state and for activation of the coagulation system, and laboratory support for anticoagulation. The third section discusses coagulation factor products. This book will be valuable for the education of trainees, practitioners, and future leaders in these fields.

Readership

Residents and fellows in hematology, transfusion medicine, pathology, and anesthesiology; practicing physicians in hematology, transfusion medicine, pathology, and anesthesiology.

Table of Contents


  • About the Editors

    Contributors

    Preface

    Acknowledgments

    Part I. Blood Banking and Transfusion Medicine

    Introduction

    1 Blood Banking and Transfusion Medicine – the Field, the Discipline and the Industry

    2 Brief History of Blood Transfusion

    3 Introduction to Quality Systems and Quality Management

    4 The Role of the Physician in the Blood Center

    Donation Process

    5 The Blood Donor, Donation Process and Technical Aspects of Blood Collection

    6 Apheresis Blood Component Collections

    7 Recipient-specific Blood Donations

    8 Adverse Donor Reactions

    Component Manufacturing

    9 Component Preparation and Manufacturing

    Donor Testing

    10 Serologic Testing of Donor Products

    11 Overview of Infectious Disease Testing

    12 HIV Screening of Donor Products

    13 Hepatitis B Screening of Donor Products

    14 Hepatitis C Screening of Donor Products

    15 West Nile Virus Screening of Donor Products

    16 Syphilis, HTLV and Chagas Testing of Donor Products

    17 Bacterial Detection Methods

    Transfusion Medicine

    18 The Role of the Transfusion Service Physician

    Testing

    19 Pretransfusion Testing

    20 Antibody Identification

    21 Direct Antiglobulin Test

    Blood Groups

    22 ABO and H Blood Group Systems

    23 Rh Blood Group System

    24 Kell and Kidd Blood Group Systems

    25 MNS and Duffy Blood Group Systems

    26 Lewis, I and P Blood Group Systems

    27 Other Blood Group Systems, Collections and Antigens

    Blood Products

    28 Red Blood Cells and Related Products

    29 Plasma Products

    30 Platelet Products

    31 Cryoprecipitate

    32 Granulocyte Products

    33 Albumin and Related Products

    34 Human Immunoglobulin Preparations

    35 Rh Immune Globulin

    Product Modifications

    36 Irradiation of Blood Products

    37 Leukoreduction of Blood Products

    38 CMV-safe Blood Products

    39 Frozen Blood Products

    40 Washed Blood Products

    41 Volume-reduced Products

    Specific Clinical Settings

    42 Neonatal and Pediatric Transfusion Medicine

    43 Perinatal Transfusion Medicine

    44 Autoimmune Hemolytic Anemias

    45 Transfusion Management in Patients with Hemoglobinopathies

    46 Transfusion of Patients Undergoing HPC and Solid-organ Transplantation

    47 Transfusion of HIV-positive Patients

    48 Management of Patients Who Refuse Blood Transfusion

    49 Platelet Transfusion Refractory Patients

    50 Massive Transfusion

    51 Perioperative Blood Management

    Transfusion Reactions

    52 Adverse Events and Outcomes Following Transfusion: an Overview

    53 Febrile Non-hemolytic Transfusion Reactions

    54 Allergic, Anaphylactoid and Anaphylactic Reactions

    55 Acute Hemolytic Transfusion Reactions

    56 Delayed Hemolytic Transfusion Reactions

    57 Transfusion-Associated Circulatory Overload

    58 Transfusion-Related Acute Lung Injury

    59 Septic Transfusion Reactions

    60 Metabolic, Hypotensive and Other Acute Reactions and Complications

    61 Posttransfusion Purpura

    62 Transfusion Associated Graft versus Host Disease

    63 Microchimerism

    64 Transfusion Related Immunomodulation

    65 Iron Overload

    66 Transfusion Transmitted Diseases

    Therapeutic Apheresis and Phlebotomy

    67 Overview of Therapeutic Apheresis

    68 Therapeutic Plasma Exchange

    69 Therapeutic Erythrocytapheresis

    70 Therapeutic Thrombocytapheresis

    71 Therapeutic Leukapheresis

    72 Extracorporeal Photopheresis

    73 LDL Pheresis

    74 Immunoadsorption

    75 Therapeutic Phlebotomy

    Cellular Therapy and Tissue Banking

    76 HPC Products

    77 Tissue Banking in the Hospital Setting

    Part II. Coagulation

    Introduction

    78 Overview of the Coagulation System

    Clinical Coagulation

    79 Approach to the Bleeding Patient

    Neonatal Thrombocytopenia

    80 Congenital Thrombocytopenia

    81 Neonatal Alloimmune Thrombocytopenia

    82 Acquired Neonatal Thrombocytopenia

    Inherited Platelet Function Disorders

    83 Bernard-Soulier Syndrome and Other GPIb-IX-V Related Receptor Defects

    84 Glanzmann Thrombasthenia

    85 Platelet Storage-granule Defects

    86 Failure to Release and Aspirin-like Defects

    Immune Thrombocytopenia

    87 Acute (Childhood) Immune Thrombocytopenic Purpura

    88 Chronic Immune Thrombocytopenic Purpura

    89 Drug-induced Thrombocytopenia

    90 Heparin-induced Thrombocytopenia

    91 Autoimmune Lymphoproliferative Syndrome

    Immune-mediated Coagulopathies

    92 Hemolytic Uremic Syndrome

    93 Thrombotic Thrombocytopenic Purpura

    94 Antiphospholipid Antibody Syndrome

    Congenital Bleeding Disorders

    95 von Willebrand Disease

    96 Hemophilia A

    97 Hemophilia B

    98 Congenital Disorders of Fibrinogen

    99 Factor XIII, α2 -Antiplasmin and Plasminogen Activator Inhibitor-1 Deficiencies

    100 Factor XI Deficiency

    101 Factor VII Deficiency

    102 Factor II, Factor V and Factor X Deficiencies

    Acquired Bleeding Disorders

    103 Bleeding Disorders in Pregnancy

    104 Vascular Bleeding Disorders

    105 Bleeding Risks with Liver Disease

    106 Bleeding Risks with Vitamin K Deficiency

    107 Bleeding Risks with Cardiac Disease

    108 Bleeding Risks with Renal Disease

    109 Bleeding Risks in Cancer

    110 Disseminated Intravascular Coagulopathy

    111 Acquired Coagulation Factor Inhibitors

    Laboratory Testing of Coagulation

    Introduction

    Screening Tests

    Laboratory Assessment of Platelet Disorders

    Laboratory Assessment of VWD

    Laboratory Assessment of Coagulation Factor Disorders

    Laboratory Assessment of Fibrinogen and Fibrinolysis

    Tests for Hypercoagulable State

    Tests for Activation of the Coagulation System

    Laboratory Support for Anticoagulation

    Coagulation Factor Concentrates

    General Handbook References

    Index




Product details

  • No. of pages: 775
  • Language: English
  • Copyright: © Elsevier Science 2009
  • Published: June 8, 2009
  • Imprint: Elsevier Science
  • eBook ISBN: 9780080922300

About the Editors

Beth H. Shaz

Beth H. Shaz, MD, is Chief Medical and Scientific Officer, Executive Vice President at New York Blood Center, and Adjunct Assistant Professor, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University. Beth is responsible for all medical and scientific activities throughout the NYBC network, which includes Rhode Island Blood Center, Innovative Blood Resources (Memorial Blood Center and Nebraska Blood Center), Community Blood Center of Greater Kansas City, and Blood Bank of Delmarva. Medical activities comprise of hemophilia services, clinical apheresis services, perioperative autologous transfusion services, cellular therapy, medical education, medical consultation, transfusion services, bone marrow donor recruitment, and donor management. Scientific activities include basic science at the Lindsey F. Kimball Research Institute and Comprehensive Cell Solutions (CCS), which contains translational and clinical research. NYBC’s scientific and medical activities focus on transfusion medicine, cell therapy, regenerative medicine, infectious disease, hematology, and personalized medicine. Beth is an editor of ten books in transfusion medicine, author of over 130 articles pertaining to transfusion medicine. She is an associate editor of TRANSFUSION and on the editorial board of BLOOD. Previously, she was an Associate Professor at Emory University School of Medicine and director of the transfusion service at Grady Memorial Hospital. Also, she was an instructor at Harvard Medical School and associate director of the transfusion service at Beth Israel Deaconess Medical Center in Boston. Beth received her MD with research distinction from the University of Michigan and BS in chemical engineering with distinction from Cornell University. She completed a general surgery internship at Georgetown University, an anatomic & clinical pathology residency at Beth Israel Deaconess Medical Center, and a transfusion medicine fellowship at Harvard Medical School.

Affiliations and Expertise

Chief Medical and Scientific Officer and Executive Vice President, New York Blood Center, New York, New York, USA Adjunct Assistant Professor, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA

Christopher D. Hillyer

Christopher D. Hillyer, MD, is President and CEO of New York Blood Center and Professor, Department of Medicine, Weill Cornell Medical College, New York, NY. Previously, he was the tenured, endowed Distinguished Service Professor, Department of Pathology and Laboratory Medicine, Emory University School of Medicine and served as director of the Emory Center for Transfusion and Cellular Therapies with responsibility for all aspects of clinical and academic transfusion medicine at Emory’s seven principle hospitals. Dr. Hillyer is an editor of twelve textbooks in transfusion medicine, author of over 160 articles pertaining to transfusion, human immunodeficiency virus, and herpes viruses, most notably cytomegalovirus. Nationally recognized as an expert in hematology and blood transfusion, Dr. Hillyer is also a past-president, board of directors of AABB and a former trustee of the National Blood Foundation. Dr. Hillyer has been awarded many million dollars in research funding from the National Institutes of Health, the Centers for Disease Control and Prevention and other agencies. He was an associate editor of Transfusion and serves on several other editorial boards. Dr. Hillyer was formally recognized for his work in Africa as part of the AABB/Emory cooperative agreement from the President’s Emergency Plan For AIDS Relief (PEPFAR), and is a recipient of two Tiffany Awards from the American Red Cross where he also served as a medical director and a member of their national Medical Advisory Board. He also received the 2014 Emily Cooley Award from AABB for his “significant commitment and contributions to the field of transfusion medicine through extensive teaching, mentoring and professional leadership, and the countless clinical, scientific and innovative resource materials he has created to educate others”. He is a co-founder of Transfusion & Transplantation Technologies, Inc (3Ti) and holds over 20 patents or patents pending. Dr. Hillyer is board certified in transfusion medicine, hematology, medical oncology and internal medicine. He received his BS from Trinity College, and his MD from the University of Rochester School of Medicine, with postgraduate training and fellowships in hematology-oncology, transfusion medicine and bone marrow transplantation at Tufts-New England Medical Center.

Affiliations and Expertise

President and Chief Executive Officer, New York Blood Center, New York, New York, USA Professor, Department of Medicine, Weill Cornell Medical College, New York, New York, USA

James Zimring

Affiliations and Expertise

Assistant Professor, Department of Pathology and Laboratory Medicine, Emory University School of Medicine; Associate Director, Emory University Special Hemostasis Laboratory, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA

Thomas Abshire

Affiliations and Expertise

Professor, Department of Pediatrics, Emory University School of Medicine; Director, Special Coagulation Laboratory, Children’s Healthcare of Atlanta; Director’s Chair in Hemostasis, Hemophilia of Georgia, Inc., USA

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