An important and comprehensive review of an expanding research area. The book will combine all classical knowledge in the field with recent advances to provide a full and comprehensive coverage of the field. Transcription factors are important in regulating gene expression, and their analysis is of paramount interest to molecular biologists studying this area. This book looks at the basic machinery of the cell involved in transcription in eukaryotes, the factors involved in transcription and progresses to look at the regulatory systems which control this machinery both within the cell and also in the wider systems of the mammalian organism.

Key Features

Key Features * Comprehensive review of an increasingly important subject area * Editor is well-known in this area, and has gathered a team of respected international contributors * A unique collection of all recent work in this area, with no existing competition * Covers both transcription factors and their control, and also both normal and disease states


Cell and Developmental Biologists, Molecular Biologists, Geneticists

Table of Contents

Contributors. Abbreviations. Preface. Basic Machinery of Transcription: RNA Polymerase II Transcription Machinery: Architecture of the Core Promoter. Rate-limiting Steps in Gene Expression. Assembly and Regulation of the TATA-binding Protein and Associated Factors. Recruitment of the RNA Polymerase II Holoenzyme. Events Subsequent to Transcription Initiation. Conclusions and Prospects. Regulatory Transcription Factors and cis-Regulatory Regions: Introduction. Regulatory Transcription Factors. Organization of cis-Acting Regulatory Regions and Combinatorial Control. Conclusions. Chromatin Structure and Regulation of Transcription: Introduction. Chromosome Architecture and Transcription. Nucleosome Structure. Chromatin Remodeling and Histone Modification in Transcription. Transcriptional Activators That Remodel Chromatin. Transcriptional Repressors That Remodel chromatin. Conclusion. DNA Binding by Transcription Factors: Principles of Protein-DNA Recognition. Architecture of DNA-binding Domains. Conclusions. Cell Regulatory Systems: Regulation of Transcription During the Cell Cycle: Introduction. An Emerging Role for Mammalian and Yeast CDKs in Transcriptional Regulation. Cdk7 and Cdk8: Two Components of the Basal Transcription Machinery. The pRB Family of Proteins. The E2F Transcription Factor. c-Myc Transcription Factor and its Partners. Role of p53 as Transcription Factor and Growth Suppressor.


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© 2001
Academic Press
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