Toxoplasma Gondii

2nd Edition

The Model Apicomplexan - Perspectives and Methods

Print ISBN: 9780123964816
eBook ISBN: 9780123965363
Imprint: Academic Press
Published Date: 21st August 2013
Page Count: 1160
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This second edition of Toxoplasma gondii reflects the significant advances in the field in the last 5 years including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists.

Toxoplasmosis is caused by a one-celled protozoan parasite known as Toxoplasma gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. In the United States, it is estimated that approximately 30% of cats, the primary carriers, have been infected by T. gondii. Approx 1 in 4 (more than 60 million) people in the USA are infected with the parasite, and in the UK between 0.5 and 1% of individuals become infected each year. By the age of 50, 40% of people test positive for the parasite. Most humans contract toxoplasmosis by eating contaminated raw or undercooked meat (particularly pork), vegetables, or milk products, by coming into contact with the T. gondii eggs from cat feaces, or by drinking contaminated water. The parasite damages the ocular and central nervous systems causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV infected patients.

Table of Contents


Preface to the First Edition

Preface to the Second Edition

List of Contributors

Chapter 1. The History and Life Cycle of Toxoplasma gondii



1.1 Introduction

1.2 The Etiological Agent

1.3 Parasite Morphology and Life Cycle

1.4 Transmission

1.5 Toxoplasmosis in Humans

1.6 Toxoplasmosis in Other Animals

1.7 Diagnosis

1.8 Treatment

1.9 Prevention and Control


Chapter 2. The Ultrastructure of Toxoplasma gondii


2.1 Invasive Stage Ultrastructure and Genesis

2.2 Coccidian Development in the Definitive Host

2.3 Development in the Intermediate Host


Chapter 3. Molecular Epidemiology and Population Structure of Toxoplasma gondii


3.1 Introduction

3.2 Genetic Markers

3.3 Genotype Designation

3.4 Molecular Epidemiological and Population Studies

3.5 Factors Affecting Transmission and Genetic Exchange

3.6 Toxoplasma Genotype and Biological Characteristics

3.7 Toxoplasma gondii Genotype and Human Disease


Chapter 4. Human Toxoplasma Infection



4.1 Clinical Manifestations and Course

4.2 Diagnosis of Infection with Toxoplasma gondii

4.3 Treatment

4.4 Prevention

4.5 Conclusions


Chapter 5. Ocular Disease due to Toxoplasma gondii



5.1 Introduction

5.2 Historical Features of Ocular Toxoplasmosis

5.3 Epidemiology

5.4 The Mechanism of Tissue Damage in Ocular Toxoplasmosis

5.5 Host Factors in Ocular Toxoplasmosis

5.6 Parasite Factors in Ocular Infection

5.7 Animal Models


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© Academic Press 2014
Academic Press
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"The field was in need of this new edition because of the information burst that has occurred with the sequencing of the genome which has led to tractable genetic systems. A one source resource for these molecular techniques is essential to the continuing progress in this research field." – Melanie T. Cushion, Ph.D., Professor and Associate Chair for Research, Division of Infectious Diseases, University of Cincinnati College of Medicine, Ohio

"...a must have for anyone interested in the field of Toxoplasma research...the cornerstone of any aspiring protozoologist’s library...I love this book for its content, layout, and ease of finding detailed information…"--JAVMA,Toxoplasma Gondii, 2nd Edition