Tissue-Specific Toxicity - 1st Edition - ISBN: 9780122088605, 9780080917627

Tissue-Specific Toxicity

1st Edition

Biochemical Mechanisms

Editors: Wolfgang Dekant H. Neumann
Print ISBN: 9780122088605
eBook ISBN: 9780080917627
Imprint: Academic Press
Published Date: 6th March 1992
Page Count: 263

Institutional Access


This volume provides an up-to-date review of the molecular mechanisms of toxicity. Individual chapters deal with specific aspects of toxicity problems associated with selected organs.

Key Features

@introbul:Key Features @bul:* Contains a review of contemporary knowledge of the molecular mechanisms of toxicity as applied to various organs

  • Contrasts with other volumes in dealing with the mechanistic approach to the subject
  • Discusses selected organs in separate chapters


Research toxicologists, pharmacologists, oncologists, and physiologists.

Table of Contents

D.J. McConkey, T.Y. Aw, and S. Orrenius, Role of the Ca2+-Mediated Endonuclease Activation in Chemical Toxicity. W.N. Aldridge, Selective Neurotoxicity: Problems in Establishing the Relevance of in Vitro data to the in Vivo Situation. J.E. Casida and R.F. Toia, Organophosphorous Pesticides: Their Target Diversities and Bioactivation. U. Andrae and H. Greim, Initiation and Promotion in Thyroid Carcinogenesis. W. Bursch, L. Fesus, and R. Schulte-Hermann, Apoptosis ('Programmed' Cell Death) and its Relevance in Liver Injury and Carcinogenesis. P. Steinberg and F. Oesch, Liver Cell Specific Toxicity of Xenobiotics. H.-G. Neumann, S. Ambs, and W. Hillesheim, The Biochemical Basis of Hepatotoxicity. W. DeKant, S. Vamvakas, and M.W. Anders, The Kidney as a Target Organ for Xenobiotics Bioactivated by Glutathione Conjugation. G.S. Yost, Bioactivation and Selectivity of Pneumotoxic Chemicals. M.E. Scheulen and H. Kappus, Anthracycines as Model Compounds for Cardiac Toxicity. Index.


No. of pages:
© Academic Press 1992
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Editor

Wolfgang Dekant

Affiliations and Expertise

Universitat Wurzburg

H. Neumann

Affiliations and Expertise

Institute of Toxicology and Pharmacology, University of Wadurzburg


@qu:"It is a fitting tribute to a man who spent much of his research career establishing the role of chemical specificity in toxicity." @source:--ATLA