Description

This volume provides an up-to-date review of the molecular mechanisms of toxicity. Individual chapters deal with specific aspects of toxicity problems associated with selected organs.

Key Features

@introbul:Key Features @bul:* Contains a review of contemporary knowledge of the molecular mechanisms of toxicity as applied to various organs * Contrasts with other volumes in dealing with the mechanistic approach to the subject * Discusses selected organs in separate chapters

Readership

Research toxicologists, pharmacologists, oncologists, and physiologists.

Table of Contents

D.J. McConkey, T.Y. Aw, and S. Orrenius, Role of the Ca2+-Mediated Endonuclease Activation in Chemical Toxicity. W.N. Aldridge, Selective Neurotoxicity: Problems in Establishing the Relevance of in Vitro data to the in Vivo Situation. J.E. Casida and R.F. Toia, Organophosphorous Pesticides: Their Target Diversities and Bioactivation. U. Andrae and H. Greim, Initiation and Promotion in Thyroid Carcinogenesis. W. Bursch, L. Fesus, and R. Schulte-Hermann, Apoptosis ('Programmed' Cell Death) and its Relevance in Liver Injury and Carcinogenesis. P. Steinberg and F. Oesch, Liver Cell Specific Toxicity of Xenobiotics. H.-G. Neumann, S. Ambs, and W. Hillesheim, The Biochemical Basis of Hepatotoxicity. W. DeKant, S. Vamvakas, and M.W. Anders, The Kidney as a Target Organ for Xenobiotics Bioactivated by Glutathione Conjugation. G.S. Yost, Bioactivation and Selectivity of Pneumotoxic Chemicals. M.E. Scheulen and H. Kappus, Anthracycines as Model Compounds for Cardiac Toxicity. Index.

Details

No. of pages:
263
Language:
English
Copyright:
© 1992
Published:
Imprint:
Academic Press
Print ISBN:
9780122088605
Electronic ISBN:
9780080917627

Reviews

@qu:"It is a fitting tribute to a man who spent much of his research career establishing the role of chemical specificity in toxicity." @source:--ATLA