Tissue Engineering

Tissue Engineering

Current Status and Challenges

1st Edition - January 25, 2022

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  • Editors: Chandra Sharma, Thomas Chandy, Vinoy Thomas, Finosh Thankam
  • eBook ISBN: 9780128240656

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Description

Tissue Engineering: Current Status and Challenges bridges the gap between biomedical scientists and clinical practitioners. The work reviews the history of tissue engineering, covers the basics required for the beginner, and inspires those in the field toward future research and application emerging in this fast-moving field. Written by global experts in the field for those studying and researching tissue engineering, the book reviews regenerative technologies, stem cell research and regeneration of organs. It then moves to soft tissue engineering (heart, vascular, muscle and 3D scaffolding and printing), hard tissue engineering (bone, dental myocardial and musculoskeletal) and translational avenues in the field.

Key Features

  • Introduces readers to the history and benefits of tissue engineering
  • Includes coverage of new techniques and technologies, such as nanotechnology and nanoengineering
  • Presents concepts, ideology and theories which form the foundation for next-generation tissue engineering

Readership

Graduate students, and early career researchers, engineers and professionals in biomedical and medical science

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Preface
  • Chapter 1: Genesis and historic evolution of tissue engineering and regenerative medicine
  • Abstract
  • Ancient concepts of tissue regeneration—“Image and imagination”
  • TE and RM in ancient era
  • Modern history of TE and RM
  • Scientific and social challenges
  • Reflections and perspective
  • References
  • Part 1: Regenerative technologies
  • Chapter 2: Overview of current technologies for tissue engineering and regenerative medicine
  • Abstract
  • Introduction
  • Historical milestones in the field of TE and RM
  • Key components of TERM
  • Advances in TE and RM
  • 3D bioprinting technology to pattern tissues
  • Next-generation technologies and future
  • Disclosure
  • References
  • Chapter 3: Myocardial tissue engineering: Fundamentals and future
  • Abstract
  • Introduction
  • Structure of cardiomyocyte
  • Cardiac extracellular matrix
  • Myocardial infarction
  • Tissue engineering
  • Hydrogels as ideal cardiac ECM templates
  • Fabrication of CTE scaffolds
  • Decellularized ECM
  • 3D bioprinting
  • Bottlenecks and future in myocardial tissue engineering
  • References
  • Chapter 4: Oro-dental regeneration
  • Abstract
  • Introduction
  • Structure of periodontium
  • Structure of various components of periodontium
  • Periodontal ECM
  • Cells of the periodontium
  • Progenitor cells
  • Tissue alterations in periodontal disease
  • Pathogenesis of periodontitis
  • Mechanism of tissue destruction in periodontitis
  • Destruction of bone
  • Destruction of extracellular matrix
  • Microbiology of periodontitis
  • Biofilms
  • Biofilm formation
  • Structure of biofilm
  • Quorum sensing
  • Immunology
  • Inflammation
  • Mediators of periodontal inflammation
  • Complement
  • DAMP
  • Regenerative dentistry
  • Conclusion
  • References
  • Chapter 5: Tissue regeneration: Fetal to adult transition
  • Abstract
  • Adult wound healing
  • Fetal wound scarless repair
  • Fetal extrinsic environment
  • Fetal tissue intrinsic components
  • Biomedical application of fetal wound healing process
  • Perspective
  • References
  • Chapter 6: Chronic wounds and tissue engineering: Prospective and promise
  • Abstract
  • Introduction
  • Types of chronic wounds
  • Etiology of chronic wounds
  • Current treatment for chronic wounds and their limitations
  • Need for tissue engineering approach for chronic wound healing
  • Pathophysiology of chronic wounds
  • Types of wound healing and definition of chronic wounds
  • Pathological hallmarks of chronic wound healing
  • Immunology of chronic wounds
  • Molecular basis of chronic wound healing
  • Extracellular matrix of chronic wounds
  • Advances in wound healing technology via tissue engineering
  • Limitations of the currently available wound healing therapies
  • Summary
  • References
  • Part 2: Stem cell research and tissue engineering
  • Chapter 7: Emerging bioengineering strategies for regulating stem cell fate: Scaffold physical and biochemical cues
  • Abstract
  • Introduction
  • Bioengineering strategies for regulating stem cell fate
  • Emerging bioengineering approaches for controlling stem cell fate
  • Concluding remarks
  • References
  • Chapter 8: Stem cell research in tissue engineering and translational medicine
  • Abstract
  • Introduction
  • Adipose-derived stem cells and their utilization in tissue engineering
  • Coculturing ASCs with chondrocytes for cartilage engineering
  • Decellularized extracellular matrix (ECM) as a bioscaffold
  • The antifibrotic potential of ASCs in Coculture with fibroblasts
  • ASCs improve fat grafting
  • ASC secretome
  • Future perspectives
  • Conclusion
  • References
  • Part 3: Tissue engineering and nanomedicine
  • Chapter 9: Electrospun nanofiber matrix for tissue repair and regeneration
  • Abstract
  • Acknowledgments
  • Introduction
  • Different methods for the preparation nanofiber matrix
  • Phase separation
  • Self-assembly
  • Electrospinning
  • Next dimensions of electrospun nanofibers in tissue repair and regeneration
  • Gas-induced 3D nanofiber fabrication
  • 3D nanofiber fabrication through rapid depressurization
  • Injectable nanofiber materials for tissue repair
  • Other forms of 3D electrospun nanofibers
  • Conclusion
  • References
  • Chapter 10: Future of nanotechnology in tissue engineering
  • Abstract
  • Introduction
  • Different nanoparticles and their applications in TERM
  • Nanofabrication methods of scaffold materials in TERM
  • Nanocomposite bio-ink materials for 3D bioprinting
  • Future perspective on clinical translation
  • Conclusions
  • References
  • Chapter 11: Green nanotechnology in cardiovascular tissue engineering
  • Abstract
  • Acknowledgments
  • Cardiovascular tissue engineering
  • The use of nanotechnology in cardiovascular TE
  • Green nanotechnology
  • Conclusion
  • References
  • Part 4: Soft tissue engineering
  • Chapter 12: Retinal repair in tissue engineering perspectives
  • Abstract
  • Introduction
  • Complexity of retinal architecture
  • Retinal degenerative diseases (RDs) requiring cell-based therapies
  • Cell-based therapies for retinal degenerative diseases
  • Cell suspension versus cell sheets for transplantation; need for bioengineering the implant before transplantation
  • Current tissue engineering strategies used for retinal repair
  • Limitations and future directions in tissue engineering of the retina
  • Conclusion
  • References
  • Chapter 13: Dental pulp tissue regeneration
  • Abstract
  • Acknowledgments
  • Background
  • Standard of care in dental pulp therapy
  • Prerequisites for pulp-dentin tissue engineering
  • Biomimetic strategies to regenerate the pulp-dentin complex
  • Tissue engineering approaches for pulp infection ablation
  • Current strategies for regeneration of the pulp-dentin complex
  • Cell homing mechanisms in dental pulp engineering
  • Pulp regeneration mediated by cell-laden scaffolds
  • 3D (bio)printing
  • Future outlook
  • References
  • Chapter 14: Prospects of collagen scaffolds for muscle regeneration
  • Abstract
  • Introduction
  • Muscle
  • Collagen
  • Conclusion and perspectives
  • References
  • Chapter 15: Nerve tissue engineering on degradable scaffold
  • Abstract
  • Summary
  • Background
  • Biomaterials for nervous tissue engineering
  • Natural polymers for neural tissue engineering
  • Synthetic polymeric materials for neural tissue engineering
  • Surface engineering to promote nerve tissue
  • Delivery of growth factors to promote nerve tissue regeneration
  • Combination of biomaterial scaffolds and cell therapy
  • Stem cells for nerve tissue regeneration
  • 3D bioprinting for nerve tissue regeneration
  • Perspective
  • References
  • Chapter 16: Bioengineering of brain organoids: Advancements and challenges
  • Abstract
  • Introduction
  • Tissue engineering approaches in stem cell culture
  • Applications of brain organoids
  • Challenges/limitations
  • Concluding remarks
  • References
  • Chapter 17: 3D printing for functional tissue engineering
  • Abstract
  • Introduction
  • Scaffold design for tissue engineering
  • 3D printing approaches for scaffold fabrication
  • 3D bioprinting
  • Current challenges
  • Conclusion and future outlook
  • References
  • Chapter 18: Biosensors in tissue engineering
  • Abstract
  • Acknowledgments
  • Introduction
  • Biosensors
  • Tissue engineering and its need for sensing
  • Applications of biosensors in tissue engineering
  • Conclusions and perspectives
  • References
  • Chapter 19: Cardiovascular regeneration
  • Abstract
  • Introduction
  • Heart regeneration capacity
  • Need for regeneration approaches
  • Cardiac regeneration strategies
  • Limitations
  • Future perspectives
  • References
  • Part 5: Hard tissue engineering
  • Chapter 20: Emerging strategies in bone tissue engineering
  • Abstract
  • Bone tissue engineering—Brief introduction
  • Development of bone
  • Damage and degeneration of bone
  • Technologies for bone regeneration
  • Future perspectives
  • References
  • Chapter 21: Dental tissue engineering
  • Abstract
  • Introduction
  • Essential components of dental tissue engineering
  • Materials and methods in dental tissue engineering
  • Recent advances in dental tissue engineering
  • Conclusions
  • References
  • Chapter 22: Musculoskeletal tissue engineering
  • Abstract
  • Introduction
  • Importance of cell source
  • Biomaterial for musculoskeletal tissue engineering
  • Biochemical and biomechanical factors
  • Significance and challenges in translational of tissue engineered products
  • Conclusion
  • References
  • Part 6: Regulatory guidelines, modeling, and ethical issues in translational tissue engineering
  • Chapter 23: Translational tissue engineering
  • Abstract
  • Introduction
  • Biomaterials
  • Cells
  • Growth factors
  • Translational tissue engineering
  • Translational bioprinting
  • Perspective and future
  • Conclusion
  • References
  • Chapter 24: Tissue engineered products—Translational avenues
  • Abstract
  • Acknowledgment
  • Summary
  • Background
  • Strategy to prepare artificial tissue-based product
  • Current approaches for formulation of tissue-based products
  • Universal donor or allogeneic scale-up-based approach
  • Patient-specific immunologic compatible or autologous approach
  • Xenogeneic or cross-species scaffolds
  • Bioprinting
  • Translational work frame for tissue engineering product
  • Clinical translation of tissue engineered construct
  • Musculoskeletal applications
  • Bioprinted bone tissue/cartilage tissue
  • Tissue engineered skin substitute
  • 3D bioprinting of skin tissue engineering
  • Tissue engineered artificial liver
  • 3D bioprinting in the domain of artificial liver
  • Tissue engineered cardiovascular tissue and heart valves
  • Bioprinted heart valves and cardiac tissues
  • Other tissue-engineered constructs
  • Risks and ethical considerations in tissue engineering products
  • Future scopes of translational tissue engineering research
  • References
  • Chapter 25: 3D modeling of the lung in health and disease
  • Abstract
  • Introduction
  • Types of 3D models of the lungs
  • Applications of lung 3D models in lung diseases
  • Future directions
  • References
  • Chapter 26: Modeling viral infection with tissue engineering: COVID-19 and the next outbreaks
  • Abstract
  • Introduction
  • SARS-CoV-2 pathophysiology
  • Traditional respiratory virus culture
  • Tissue engineering-based models
  • Conclusions and future directions
  • References
  • Chapter 27: Ethical issues
  • Abstract
  • Acknowledgment
  • Introduction
  • Equitable distribution of emerging technologies
  • Allocation of resources
  • Political influence and interference on tissue engineering
  • Scientific misconduct and its impact
  • Real-life ethical challenges
  • Future research
  • Conflicts of interest
  • Intellectual property
  • Conclusion
  • References
  • Index

Product details

  • No. of pages: 724
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: January 25, 2022
  • Imprint: Academic Press
  • eBook ISBN: 9780128240656

About the Editors

Chandra Sharma

Chandra P. Sharma iChandra P. Sharma is Adjunct Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, and Hon. Emeritus Professor, College of Biomedical Engineering & Applied Sciences, Purbanchal University, Nepal. He was formerly Senior Scientist, G and Head, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Trivandrum and has been Head, Biosurface Technology Division, SCTIMST, Trivandrum. He has also been Associate Head, Biomedical Technology Wing, and Associate Dean, SCTIMST Trivandrum. He has been recognized with various awards and honors such as MRSI medal (1994) and MRSI-ICSC Superconductivity & Materials Science Annual Prize Award 2009 - Materials Research Society of India, Distinguished Scientist award - Society for Biomaterials and Artificial Organs, India (SBAOI) and shares Whitaker and National Science Foundation Award - International Society for Artificial Organs (ISAO) USA.

Affiliations and Expertise

Adjunct Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, and Hon. Emeritus Professor, College of Biomedical Engineering and Applied Sciences, Purbanchal University, Nepal

Thomas Chandy

Dr. Thomas Chandy is a biomaterial expert with unique combination of medical device and technical knowledge. He has strong academic credentials in human physiology and bio-compatible materials with test methods and model development. Dr. Chandy has published over 80 scientific papers in international Journals and 3 patents in the medical device and drug delivery area. Reviewer to 7+ international journals of repute in Drug delivery and Biomedical Research. Twenty-Five years of experience as a project lead in medical device and technology development. Strong experience with broad range of medical products including polymeric and tissue-based implantable, site specific drug delivery, medical diagnostics and combination devices. Product/process development skills with demonstrated success from concept through commercialization involving selection of materials, characterization, biological evaluation of materials, bench, feasibility tests and pre-clinical (animal) testing.

Affiliations and Expertise

Senior Test Engineer and Project Lead, Phillips Medisize, Hudson, Wisconsin, USA

Vinoy Thomas

Dr. Vinoy Thomas is an assistant professor in the Department of Materials Science and Engineering at the University of Alabama at Birmingham. training spans from Chemistry/Polymers to Materials Science and Nanotechnology with specific training and expertise in Polymers and Biomaterials. He also holds secondary appointments at the Department of Biomedical Engineering and Department of Environmental Science & Health. He is also a Senior Research Scientist at the Center for Nanoscale Materials and Biointegration. After his PhD in Biomaterials & Technology he completed postdoctoral training at Friedrich-Schiller University, Germany, and at the National Institute of Standards & Technology (NIST). His research focuses on biomaterials processing-property relationships, nanomaterials for tissue engineering, and nanodiamonds for joint-implants.

Affiliations and Expertise

Assistant Professor, Department of Materials Science and Engineering, University of Alabama, Birmingham, USA

Finosh Thankam

Dr. Finosh Thankam is an assistant professor and researcher in Tissue Engineering and Regenerative Medicine, in the Department of Translational Research, at the Western University of Health Sciences, in Pomona, CA. His undergraduate studies were in Biochemistry, before completing his post-graduate degree in Medical Biochemistry from Mahatma Gandhi University, in India. As a research fellow he was exposed to the new world of tissue engineering and regenerative medicine and published many original articles on various aspects of cardiac tissue engineering. His current research interests include investigating the pathogenesis of various musculoskeletal disorders, and cardiovascular diseases, and applying the knowledge and principles of tissue engineering to develop artificial tissue constructs to improve the care for the sufferers.

Affiliations and Expertise

Assistant Professor, Tissue Engineering and Regenerative Medicine, Department of Translational Research, Western University of Health Sciences, Pomona, California, USA

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