Tissue Barriers in Disease, Injury and Regeneration

Tissue Barriers in Disease, Injury and Regeneration

1st Edition - June 19, 2021

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  • Editor: Nikolai Gorbunov
  • Paperback ISBN: 9780128185612

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Description

Tissue Barriers in Disease, Injury and Regeneration focuses on the molecular and cellular fundamentals of homeostatic and defense responses of tissue barriers, covering the damaging impacts and exposure to pathogens and engineered nanomaterials. Sections emphasize the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells, along with reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and metabolic status. Other sections cover the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, vasculature of blood-tissue barriers, and more.

Key Features

  • Includes special emphasis on the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells in the development of reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and in metabolic status
  • Examines the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, the vasculature of blood-tissue barriers, and mucosa and external epithelium

Readership

Doctoral students, researchers and professors who are involved in the broad area of patho-biology and tissue barriers. Research scientists and practicing clinicians/surgeons, and experts in pharmaceutical technology and nanotoxicology of nanomaterials will also have an interest

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Preface
  • Chapter One. Roles and distribution of telocytes in tissue organization in health and disease
  • 1. Introduction
  • 2. Telocytes—definition and history
  • 3. Localization and identification methods
  • 4. Physiological functions of telocytes
  • 5. Roles of telocytes in disease
  • 6. Perspectives and conclusion
  • Chapter Two. Effects of radiation on endothelial barrier and vascular integrity
  • 1. Introduction: radiation-induced permeability of the vasculature
  • 2. Direct mechanisms of radiation-induced vascular effects
  • 3. Indirect mechanisms of radiation-induced vascular effects
  • 4. Conclusions
  • Chapter Three. How severe RNA virus infections such as SARS-CoV-2 disrupt tissue and organ barriers—Reconstitution by mesenchymal stem cell-derived exosomes
  • 1. COVID-19 and the contribution by immune effector cells
  • 2. Immune-mediated pathogenesis
  • 3. Acute lung injury, increased endothelial permeability, and loss of organ barrier function
  • 4. Endogenous repair systems
  • 5. The role of mesenchymal stem cells
  • 6. Extracellular vesicles: Exosomes and small microvesicles
  • 7. Tissue reconstitutive mechanisms by mesenchymal stem cell-small extracellular vesicles in COVID-19
  • 8. Source of exosomes
  • 9. Mesenchymal stem cell-small extracellular vesicles as investigational new drug
  • 10. Exosome enrichment
  • Chapter Four. The retinal pigment epithelium: at the forefront of the blood-retinal barrier in physiology and disease
  • 1. Introduction
  • 2. Inner blood-retinal barrier
  • 3. Outer blood-retinal barrier
  • 4. Structural changes on optical coherence tomography and fluorescein angiography in the internal blood-retinal barrier and outer blood-retinal barrier in disease states
  • 5. Conclusions
  • Chapter Five. Appressorium morphogenesis and penetration in rice blast fungus
  • 1. Introduction
  • 2. Appressorium induction and differentiation
  • 3. Appressorium maturation and function
  • 4. Appressorium penetration and invasive growth
  • 5. Conclusion
  • Chapter Six. Mesenchymal stem cells and exosomes in tissue regeneration and remodeling: characterization and therapy
  • 1. Introduction
  • 2. Mesenchymal stem cell characterization
  • 3. Mesenchymal stem cells and tissue or organ therapy
  • 4. Replacement of mesenchymal stem cells with exosomes including anti-inflammatory cytokines, growth factors, and micro-RNAs
  • 5. Conclusions
  • Index

Product details

  • No. of pages: 206
  • Language: English
  • Copyright: © Elsevier 2021
  • Published: June 19, 2021
  • Imprint: Elsevier
  • Paperback ISBN: 9780128185612

About the Editor

Nikolai Gorbunov

Dr. Gorbunov is currently Research Associate Professor with the Henry M. Jackson Foundation for the Advancement of Military Medicine in Bethesda, Maryland. Dr. Gorbunov received his Ph.D. from the Russian Academy Sciences in St. Petersburg, Russia. He then completed a two-year postdoctoral training in Biomedicine at the Research Center of the Consorzio "Mario Negri" Sud (Italy) and a two-year DOE postdoctoral training program in Radiation Sciences at the University of Pittsburgh, Graduate School of Public Health. Pittsburgh, Pennsylvania. In 1994 and 2000 Dr. Gorbunov was a recipient of the National Research Council Fellowship Awards to pursue the NRC Senior Research Associateship at the Walter Reed Army Institute of Research (WRAIR). A long-term interest is the tissue barrier homeostasis in traumatic injury, inflammation, stress, and immunosuppression. Working on models of blast-related injury in a research team Dr. Gorbunov described the mechanism of the inflammatory response to shock wave induced pulmonary trauma and defined the role of cell redox signaling in the related pulmonary microvascular remodeling. He introduced the redox metabolic machinery balanced by antioxidants as an "interface module" which mediates systemic response to the blast-induced oxidative stress. The current research interest is focused on innate defense mechanisms that underlie homeostatic responses of tissue barriers to radiation-induced injury and associated bacterial sepsis. He explores this area at the Armed Forces Radiobiology Research Institute (AFRRI) and the Uniformed Services University of the Health Sciences (Bethesda, Maryland).

Affiliations and Expertise

Research Associate Professor, Henry M. Jackson Foundation for the Advancement of Military Medicine in Bethesda, Maryland, USA

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