Thermoregulation Part I

Thermoregulation Part I

From Basic Neuroscience to Clinical Neurology

1st Edition - November 16, 2018

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  • Editor: Andrej A. Romanovsky
  • eBook ISBN: 9780444639134
  • Hardcover ISBN: 9780444639127

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Thermoregulation, Part I: From Basic Neuroscience to Clinical Neurology, Volume 154, not only reviews how body temperature regulation changes in neurological diseases, but also how this aspect affects the course and outcomes of each disease. Other sections of the volume review three therapeutic approaches that are aimed at manipulating body temperature, including induced hypothermia, induced hyperthermia and antipyretic therapy. The book is comprised of nine sections across two volumes, five dealing with the basic aspects of body temperature regulation and four dealing with the clinical aspects. Basic sections cover the Thermoregulation system, Thermoreceptors, Thermoeffectors, Neural pathways, and Thermoregulation as a homeostatic function. In addition, the book covers the physiology and neuroanatomy of the thermoregulation system and provides descriptions of how the regulation of body temperature intervenes with other physiological functions (such as sleep, osmoregulation, and immunity), stress, exercise and aging. Basic sections serve as an introduction to the four clinical sections: Body Temperature, Clinical Significance, Abnormal Body Temperature, Thermoregulation in Neurological Disease and Therapeutic Interventions.

Key Features

  • Presents a clear, logical pathway from the fundamental physiology of thermoregulation, through neurobiology, to clinical applications and disease
  • Enables researchers and clinicians to better understand the value of temperature measurement in disease and the use of temperature as a therapy
  • Integrates content from a broad field of research, including topics on the molecular physiology of temperature receptors, to the management of accidental hypothermia


Basic and clinical researchers in neuroscience; fellows, residents, and practicing clinicians in neurology as well as other clinicians whose clinical focus includes temperature control (internal medicine, endocrinology)

Table of Contents

    1. The thermoregulation system and how it works

    2. Peripheral thermoreceptors in innocuous temperature detection
    3. Molecular basis of peripheral innocuous cold sensitivity
    4. Molecular basis of peripheral innocuous warmth sensitivity
    5. Peripheral and central determinants of skin wetness sensing in humans
    6. Nociceptors. Thermal allodynia and thermal pain
    7. Central thermoreceptors
    8. Molecular Basis of Central Thermosensation

    9. Brown adipose tissue as a heat-production thermoeffector
    10. Shivering and nonshivering thermogenesis in skeletal muscles
    11. Skin vasoconstriction as a heat-conservation thermoeffector
    12. Cutaneous active vasodilation as a heat-loss thermoeffector
    13. Sweating as a heat-loss thermoeffector
    14. Panting as a heat-loss thermoeffector
    15. Thermal comfort

    16. Afferent pathways for autonomic and shivering thermoeffectors
    17. Efferent neural pathways for the control of brown adipose tissue thermogenesis and shivering
    18. Efferent thermoregulatory pathways regulating cutaneous blood flow and sweating
    19. Central neural substrates involved in temperature discrimination, thermal pain, thermal comfort, and thermoregulatory behavior

    20. Body temperature and sleep
    21. Skin Temperature, Sleep and Vigilance
    22. Thermoregulation and the ultradian basic rest-activity cycle
    23. Thermoregulation and age
    24. Temperature and adaptive immunity
    25. Interactions between body fluid homeostasis and thermoregulation in humans
    26. Obesity and Thermoregulation
    27. Thermoregulation and nausea
    28. Neurogenesis in the thermoregulatory system


Product details

  • No. of pages: 496
  • Language: English
  • Copyright: © Elsevier 2018
  • Published: November 16, 2018
  • Imprint: Elsevier
  • eBook ISBN: 9780444639134
  • Hardcover ISBN: 9780444639127

About the Series Volume Editor

Andrej A. Romanovsky

Andrej A. Romanovsky
Andrej A. Romanovsky, MD, PhD, is an integrative physiologist and neuroscientist studying body temperature regulation. Originally from St. Petersburg, Russia, Dr. Romanovsky was granted his MD with Distinction by the Ivan Pavlov Medical University (St. Petersburg) in 1984. He completed his pathophysiology residency in 1986 at the Pavlov Institute of Experimental Medicine of the Russian Academy of Medical Sciences in St. Petersburg. In 1989, he received a PhD in physiology from the Institute of Physiology of the National Academy of Sciences (Minsk, Belarus). Following postdoctoral training at the University of Tennessee Medical School in Memphis (1991–1994), Dr. Romanovsky accepted the position of Associate Scientist and Director of the Thermoregulation Laboratory at the Legacy Health System in Portland, Oregon (1994–2000). Since 1999, he has been working as Professor at St. Joseph’s Hospital and Medical Center in Phoenix, Arizona, where he directs his basic research laboratory (FeverLab). He also holds an Adjunct Professor appointment at the Arizona State University School of Life Sciences in Tempe, Arizona. Dr. Romanovsky has published more than 100 articles in peer-reviewed scientific journals. His research has been funded by the National Institutes of Health, the State of Arizona, and a number of pharmaceutical companies and foundations. He has served on study sections and reviewed grant applications for the National Institutes of Health, the National Science Foundation, the Medical Research Council (UK), the Canadian Institutes of Health Research, the Swedish Research Council, the Dutch Research Council, the National Research Foundation (South Africa), the National Council of Romania, the Polish National Science Center, the government of Hong Kong, and other agencies in many countries. He has served on boards of multiple journals including the American Journal of Physiology (Regulatory, Integrative and Comparative Physiology), Public Library of Science One (Academic Editor), and Acta Physiologica Hungarica (International Board), and is the founding Editor-in-Chief of the journal Temperature. He is a co-founder of Catalina Pharma, Inc.

Affiliations and Expertise

Professor, Trauma Research, St. Joseph’s Hospital and Medical Center, Phoenix, AZ; Adjunct Professor, School of Life Sciences, Arizona State University, Tempe, AZ, USA

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  • Tobias S. Thu Jan 31 2019

    The the authoritative text on thermoregulation in 2019.

    Having worked with thermoregulation both in pediatrics, and now in the medical device industry for some years, the lack of a proper reference has been a desideratum. The last text even close, but far from as extensive, being Dr. Phillip Mackowiak´s "Fever Basic Mechanism and Managment, Second Edition" from 1997, "Thermoregulation: From Basic Neuroscience clinical neurology" Part I and II fills this void perfectly. Clearly written, concise, extensive and authoritative, it covers all aspect of thermometry and thermoregulation I can think of, from molecular basis to thermoregulation in brain injuries. Hopefully, this work will not be a gem hidden in specialty wards but will help revitalize thermoregulation as the important clinical parameter it actually is. An impressive editorial feat by Prof. Romanovsky, clearly facilitated by his extensive and diverse experience in physiology, neuroscience, traumatology and running Highly recommended.