Therapeutic Strategies in Cancer Biology and Pathology

1st Edition

Authors: Gajanan Sherbet
Hardcover ISBN: 9780124165700
eBook ISBN: 9780124165908
Imprint: Elsevier
Published Date: 31st July 2013
Page Count: 310
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Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination. The emphasis in this book is on how appropriate these genes are as molecular targets and how practicable are the constituents of their signal transduction systems as potential candidates and how accessible they are to targeted therapy. Written in a straightforward and clear style with background information supporting the new research, this book will be useful for students and researchers in cancer therapies.

Key Features

  • Identifies molecular targets and their accessibility for therapeutic intervention
  • Provides information on biological features of tumor development and dissemination
  • Background information provided for each topic


Developmental biologists, cell biologists and cancer researchers

Table of Contents





Part 1: RNA Interference in Genetic Regulation

1. The Biogenesis and Functions of MicroRNAs

2. Association of miRNAs with Pathogenesis

The Genesis of DiGeorge Syndrome

Association of the Glyoxalase Pathway with miRNA Function

3. Are miRNAs Suitable Targets for Cancer Therapy?

A Resumé of mTOR Signalling

miRNAs, Cell Proliferation and Apoptosis

miRNAs in EMT, and Cell Motility and Invasion

miRNAs and Tumour Angiogenesis

miRNAs, Tumour Growth, Invasion and Metastasis

miRNAs and Chemo/Radiosensitivity of Tumours

The Therapeutic Potential of miRNAs

Part 2: EMT Associated Gene Targeting

4. Hedgehog Signalling in EMT

5. Targeted Inhibition of Hh, Wnt, TGF-β Signalling Complex

SMO Is a GPCR Component of Hh Signalling

Small Molecule Inhibitors of SMO

HDAC Inhibitors Combination with Hh Inhibition

Targeting Gli1 in Deregulated Hh Signalling

6. Encountering Aberrant Wnt Signalling

The Canonical and Non-canonical Wnt Routes of Signalling

Fzd and LRP Inhibition, Dkk and SFRPs

Fzd and DVL Interaction

7. Therapeutic Targeting of TGF-β Signalling

Antisense Oligonucleotide Trabedersen (AP 12009)

Anti-TGF-β Monoclonal Antibodies

Small Molecule Inhibitors of the TGF-β Receptor Family

Inhibition of Type RIII Function

8. EGFR Signalling in EMT

E-cadherin in EGFR Signalling

EGFR Signalling Path to EMT

ECM and Cell Membrane Components in EGFR Signalling

EGFR and TGF-β Signalling Pathways Interact in EMT

Part 3: Therapeutic Deployment of Metastasis-Associated Gene Function

9. S100A4 as a Potential Target

The Spectrum of Biological Function of S100A4

Influence of Wnt Signalling on S100A4 Expression

Osteopontin a


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About the Author

Gajanan Sherbet

Dr. G.V. Sherbet is DSc (Doctor of Science) London University; FRCPath (Fellow of the Royal College of Pathologists). He was a member of the scientific staff at the Chester Beatty Research Institute and University College Medical School of London, and Deputy Director of the Cancer Research Unit in the Medical School of University of Newcastle upon Tyne. He has held several prestigious fellowships, such as the Beit Memorial and the Williams and Cancer Research Campaign fellowships. Dr Sherbet is Adjunct professor at the Institute for Molecular Medicine Huntington Beach CA. He is on the editorial boards of many international scientific and medical journals.

Affiliations and Expertise

School of Electrical Electronic and Computer Engineering,University of Newcastle upon Tyne UK and The Institute for Molecular Medicine, Huntington Beach, CA, USA


"The major motivation for this volume on cancer therapeutic strategies is to identify items of therapeutic interest in the biological functioning of high-profile metastasis suppressor and promoter genes and uncover links and nodes of their signaling pathways in order to directly or indirectly countermand the biological effects of these genes."--Reference & Research Book News, December 2013