Description

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.

Key Features

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.

Readership

Researchers and students in cell, molecular and developmental biology

Table of Contents

Section I: New Approaches to Studying UPR and Cell Stress

  1. CFTR Expression Regulation by the Unfolded Protein Response
  2. Rafal Bartoszewski, Andras Rab, Lianwu Fu, Sylwia Bartoszewska, James Collawn and Zsuzsa Bebok

  3. GRP78/BiP Chapter: Modulation of GRP78/BiP in Altering Sensitivity to Chemotherapy
  4. Thomas C. Chen

  5. Targeting the Unfolded Protein Response in Cancer Therapy
  6. Marina V. Backer, Joseph M. Backer & Prakash Chinnaiyan

  7. Large-scale analysis of UPR-mediated apoptosis in human cells
  8. Andrew M. Fribley, Justin R. Miller, Tyler E. Reist1, Michael U. Callaghan and Randal J. Kaufman

  9. Quantitative Analysis of amino acid oxidation markers by tandem mass spectrometry
  10. Anuradha Vivekanandan-Giri, Jaeman Byun and Subramaniam Pennathur

  11. Animal models in the study of the unfolded protein response
  12. Hemamalini Bommiasamy and Brian Popko

  13. Measurement of Fluoride-induced Endoplasmic Reticulum Stress Using Gaussia luciferase
  14. Ramaswamy Sharma, Masahiro Tsuchiya, Bakhos A. Tannous and John D. Bartlett

  15. Analysis of nelfinavir-induced endoplasmic reticulum stress
  16. Ansgar Brüning

  17. Using temporal genetic switches to synchronize the unfolded protein response in cell populations in vivo
  18. Alexander Gow

  19. Glycoprotein maturation and the UPR
  20. Andreas J. Hülsmeier, Michael Welti and Thierry Hennet

  21. Monitoring and Manipulating Mammalian Unfolded Protein Response
  22. Nobuhiko Hiramatsu, Victory T. Joseph and Jonathan H. Lin

  23. A screen for mutants requiring activation of the unfolded protein response for viability
  24. Guillaume Thibault and Davis T.W. Ng

  25. Signalling Pathways of Proteostasis Network Unreveale

Details

No. of pages:
464
Language:
English
Copyright:
© 2011
Published:
Imprint:
Academic Press
Electronic ISBN:
9780123859297
Print ISBN:
9780123859280

About the serial-volume-editor

P. Michael Conn

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn serve