The Structure and Metabolism of the Pancreatic Islets

The Structure and Metabolism of the Pancreatic Islets

A Centennial of Paul Langerhans' Discovery

1st Edition - January 1, 1970

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  • Editors: S. Falkmer, B. Hellman, I.-B. Täljedal
  • eBook ISBN: 9781483186627

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The Structure and Metabolism of the Pancreatic Islets: A Centennial of Paul Langerhans' Discovery is a collection of that presents the advancement in the field of pancreatic islet research, particularly in the area of biosynthesis and secretion of insulin. The title also serves as a commemorative material to Paul Langerhans' work. The text first covers the differentiation and growth of the endocrine pancreas, and then proceeds to tackling α- and ß-cells. Next, the selection deals with the glucose metabolism of the pancreatic islets. The text also discusses the biosynthesis and storage of insulin, along with insulin release. The seventh part details pancreatic islets and diabetes. The book will be of great use to students, researchers, and practitioners of medicine.

Table of Contents

  • Preface

    List of Participants

    Opening Address

    Paul Langerhans. A Memorial Lecture

    Part I. Differentiation and Growth of the Endocrine Pancreas

    Islet Cell Proliferation in Experimental and Genetic Diabetes

    The Significance of Agranular and Ciliated Islet Cells

    Present State of the Evidence for Mixed Endocrine and Exocrine Pancreatic Cells in Spiny Mice

    Observations on the Type and Origin of the Hormone-producing Cells in the Zollinger-Ellison and Verner-Morrison Syndrome

    Catecholamines in a Transplantable Islet-cell Tumor of the Golden Hamster

    Comparison of Cultured and Transplanted Islets of the Guinea-pig

    Mono-layer Culture of Pancreatic Islet Cells

    Control of Endocrine Function in Organ Cultures of Fetal Rat Pancreas

    Part II. Morphology and Physiology of the α-Cells

    The Fine Structure of Pancreatic α-Cells Under Normal and Experimental Conditions

    Intracellular "α-Granulolysis" in α-Cells of Diabetic Animals

    The Cellular Origin of Pancreatic Glucagon

    Isolation and Histochemical Characterization of Islet α-Cells

    Mono-aminergic Mechanisms in the Pancreatic α-Cells

    Regulation of Glucagon Release In Vivo

    Glucagon Secretion in Normal Rats and Hamsters and in Hamsters with a Transplantable Islet Cell Tumor

    Part III. Morphology of ß-Cell Function

    Ultra-structural Aspects of the Function of Rabbit ß-Cells

    The Mechanism of Emiocytic Insulin Release

    Evidence for Different Modes of Insulin Secretion

    Histochemical Evidence for a Sulfonylurea Effect on the Zinc Content of the Pancreatic Islets

    Role of Sulfhydryl Compounds and Heavy Metals in the Synthesis and Storage of Insulin

    Comparative Histochemical Studies of Mammalian Pancreatic Islets

    Part IV. Glucose Metabolism of the Pancreatic Islets

    Glucose Phosphorylation and Glucose Oxidation in Mouse Pancreatic Islets and the Release of Insulin

    Glucose-6-Phosphatase in Pancreatic ß-Cell Metabolism

    The Activity Pattern of Enzymes Associated with Glycogen Metabolism in the Islets of Langerhans

    On the Functional Significance of the Pancreatic ß-Cell Glycogen

    The Role of the Pentose Phosphate Pathway in Insulin Secretion

    Photo-kinetic Measurements of the ATP and ADP Levels in Isolated Islets of Langerhans

    Quantitative Enzyme Pattern and Insulin Content of Human Islets of Langerhans

    Electrical Activity in Islet Cells

    Oxygen Consumption of the ß-Cells in Relation to Insulin Release

    Respiration of the ß-Cells in the Presence of Sulfonylureas

    Part V. Biosynthesis and Storage of Insulin

    Pro-insulin and Insulin Biosynthesis

    Distribution and Radioactivity of Acid-Ethanol Soluble Protein, Pro-insulin, and Insulin in Sub-cellular Fractions from Islet Tissue of the Cod (Gadus Callarias)

    Ribonucleic Acid and Protein Synthesis in Isolated Cod-fish Islets

    Ribonucleic Acid Metabolism and Insulin Synthesis

    Demonstration of Pro-insulin in the ß-Cells of Bovine Islets by a Specific Fluorescent Antibody

    Preparation and Properties of Isolated Mammalian Insulin Storage Granules

    Properties of Isolated ß-Granules in SuspensionKY

    Part VI. Insulin Release

    In Vitro Studies Suggesting a Two-compartmental Model for Insulin Secretion

    Dynamics of Insulin Secretion: Comparison of Various In Vitro Preparations

    Biochemical, Pharmacological, and Physiological Aspects of the Adenylcyclase-Phosphodiesterase System in the Pancreatic ß-Cells

    Feedback Regulation of Insulin Secretion by Insulin: Role of 3',5'-Cyclic AMP

    A Possible Role of the Pancreatic α1 and α2-Cells as Local Regulators of Insulin Secretion

    Intestinal Hormones and Insulin Release and Biosynthesis

    The Insulin-releasing Activity of Extracts of the Porcine Intestinal Tract

    The Effect of Glucose on the Insulin Secretion in Foetal and Newborn Rats

    Effects of Different Metabolites on the Storage and Release of Insulin by Duck Pancreas In Vitro

    Ionic Mechanisms in the Regulation of Insulin Secretion

    Part VII. Pancreatic Islets and Diabetes

    Remarks on Pancreatic ß-Cells in Spontaneous and Experimental Diabetes in Small Laboratory Rodents

    Insulin Synthesis and Secretion by Isolated Islets of Spontaneously Diabetic Chinese Hamsters

    Pancreatic Glucagon Secretion

    The Pancreatic ß-Cells in the Pathogenesis of Human Diabetes Mellitus

    Part VIII. Summing up of the Conference

    Summing up of the Conference

    Index of Authors and Participants in the Discussions

    Subject Index

Product details

  • No. of pages: 580
  • Language: English
  • Copyright: © Pergamon 1970
  • Published: January 1, 1970
  • Imprint: Pergamon
  • eBook ISBN: 9781483186627

About the Editors

S. Falkmer

B. Hellman

I.-B. Täljedal

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