The Role of Membranes in Metabolic Regulation - 1st Edition - ISBN: 9780124878402, 9780323141246

The Role of Membranes in Metabolic Regulation

1st Edition

Editors: Myron Mehlman
eBook ISBN: 9780323141246
Imprint: Academic Press
Published Date: 1st January 1972
Page Count: 444
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Description

The Role of Membranes in Metabolic Regulation is the second volume in a series of in-depth reviews of specific areas of metabolic regulation. This volume is based on the 1972 symposium on The Role of Membranes in Metabolic Regulation held at the University of Nebraska Medical School. Separating 20 manuscripts into chapters, this book emphasizes membrane structure and function as well as utilization of affinity chromatography for purification of biologically important cellular components, called membrane receptors. It also discusses the role of phospholipids in hormone sensitive enzyme systems, with an emphasis on adenylate cyclase system. Other chapters describe the induction of steroidogenesis by corticotrophin and its synthetic analogues coupled by an azo linkage in free adrenal cells and the interaction between the mammary epithelial cells and insulin-sepharose systems. Topics on erythrocyte as a system for studying the properties of adenylate cyclase and the ionic effects in the sugar transport regulation in muscle are discussed in the concluding chapters of the book. Biochemists, physiologists, pharmacologists, physicians, researchers, and all others interested in the concepts about metabolic regulation will find this series of great value.

Table of Contents


Contributors

Preface

Experiment, Hypothesis, and Theory in the Development of Concepts of Cell Membrane Structure

Freeze-Etch Images of an Ion Transporting Membrane

Membranal Ca++ Translocation and Cholinergic Receptor Activation

Antibiotic A23187 as a Probe for the Study of Calcium and Magnesium Function in Biological Systems

Regulation of Glucose Transport in Heart Muscle and Erythrocytes

Carboxylic Ionophores as Mobile Carriers for Divalent Ions

Regulation of the Translocation of Adenine Nucleotides across the Inner Mitochondrial Membrane by Long Chain Acyl CoA Esters

NAD+ Redox State as Related to Mitochondrial and Cell Membranes

Affinity Chromatographic Studies of the Insulin Receptivity Associated with Intact Fat Cells, Their Membranes, and Solubilized Extracts

The Interaction of Insulin with Fat Cells: Its Physiological Significance

The Role of Phospholipids in the Activation of Myocardial Adenylate Cyclase by Glucagon, Histamine, and the Catecholamines

Characterization and Purification of the Cardiac β-Adrenergic Receptor

Interaction between Na+-Dependent Transport Systems: Possible Mechanistic Significance

The Stimulation of Corticosteroidogenesis in Isolated Rat Adrenal Cells by Agarose-ACTH

Insulin, Glucocorticoid, and Enzyme Activity

Insulin and the Mammary Epithelial Cell Membrane

Glucagon Receptor

Hormone Receptors, II. Biological Activity of Agarose-Glucagon, and Isolation of Glucagon-Binding Proteins from Solubilized Liver Plasma Membranes by Gel and Affinity Chromatography

Studies on Factors Affecting the Adenylate Cyclase System of Rat Erythrocytes

Ionic Effects in the Regulation of Sugar Transport in Muscle

Subject Index


Details

No. of pages:
444
Language:
English
Copyright:
© Academic Press 1972
Published:
Imprint:
Academic Press
eBook ISBN:
9780323141246

About the Editor

Myron Mehlman