The Role of Membranes in Metabolic Regulation - 1st Edition - ISBN: 9780124878402, 9780323141246

The Role of Membranes in Metabolic Regulation

1st Edition

Editors: Myron Mehlman
eBook ISBN: 9780323141246
Imprint: Academic Press
Published Date: 1st January 1972
Page Count: 444
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The Role of Membranes in Metabolic Regulation is the second volume in a series of in-depth reviews of specific areas of metabolic regulation. This volume is based on the 1972 symposium on The Role of Membranes in Metabolic Regulation held at the University of Nebraska Medical School. Separating 20 manuscripts into chapters, this book emphasizes membrane structure and function as well as utilization of affinity chromatography for purification of biologically important cellular components, called membrane receptors. It also discusses the role of phospholipids in hormone sensitive enzyme systems, with an emphasis on adenylate cyclase system. Other chapters describe the induction of steroidogenesis by corticotrophin and its synthetic analogues coupled by an azo linkage in free adrenal cells and the interaction between the mammary epithelial cells and insulin-sepharose systems. Topics on erythrocyte as a system for studying the properties of adenylate cyclase and the ionic effects in the sugar transport regulation in muscle are discussed in the concluding chapters of the book. Biochemists, physiologists, pharmacologists, physicians, researchers, and all others interested in the concepts about metabolic regulation will find this series of great value.

Table of Contents

Contributors Preface Experiment, Hypothesis, and Theory in the Development of Concepts of Cell Membrane Structure Freeze-Etch Images of an Ion Transporting Membrane Membranal Ca++ Translocation and Cholinergic Receptor Activation Antibiotic A23187 as a Probe for the Study of Calcium and Magnesium Function in Biological Systems Regulation of Glucose Transport in Heart Muscle and Erythrocytes Carboxylic Ionophores as Mobile Carriers for Divalent Ions Regulation of the Translocation of Adenine Nucleotides across the Inner Mitochondrial Membrane by Long Chain Acyl CoA Esters NAD+ Redox State as Related to Mitochondrial and Cell Membranes Affinity Chromatographic Studies of the Insulin Receptivity Associated with Intact Fat Cells, Their Membranes, and Solubilized Extracts The Interaction of Insulin with Fat Cells: Its Physiological Significance The Role of Phospholipids in the Activation of Myocardial Adenylate Cyclase by Glucagon, Histamine, and the Catecholamines Characterization and Purification of the Cardiac β-Adrenergic Receptor Interaction between Na+-Dependent Transport Systems: Possible Mechanistic Significance The Stimulation of Corticosteroidogenesis in Isolated Rat Adrenal Cells by Agarose-ACTH Insulin, Glucocorticoid, and Enzyme Activity Insulin and the Mammary Epithelial Cell Membrane Glucagon Receptor Hormone Receptors, II. Biological Activity of Agarose-Glucagon, and Isolation of Glucagon-Binding Proteins from Solubilized Liver Plasma Membranes by Gel and Affinity Chromatography Studies on Factors Affecting the Adenylate Cyclase System of Rat Erythrocytes Ionic Effects in the Regulation of Sugar Transport in Muscle Subject Index


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© Academic Press 1972
Academic Press
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Myron Mehlman

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