The Role of Membranes in Metabolic Regulation

The Role of Membranes in Metabolic Regulation

1st Edition - January 1, 1972

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  • Editor: Myron Mehlman
  • eBook ISBN: 9780323141246

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The Role of Membranes in Metabolic Regulation is the second volume in a series of in-depth reviews of specific areas of metabolic regulation. This volume is based on the 1972 symposium on The Role of Membranes in Metabolic Regulation held at the University of Nebraska Medical School. Separating 20 manuscripts into chapters, this book emphasizes membrane structure and function as well as utilization of affinity chromatography for purification of biologically important cellular components, called membrane receptors. It also discusses the role of phospholipids in hormone sensitive enzyme systems, with an emphasis on adenylate cyclase system. Other chapters describe the induction of steroidogenesis by corticotrophin and its synthetic analogues coupled by an azo linkage in free adrenal cells and the interaction between the mammary epithelial cells and insulin-sepharose systems. Topics on erythrocyte as a system for studying the properties of adenylate cyclase and the ionic effects in the sugar transport regulation in muscle are discussed in the concluding chapters of the book. Biochemists, physiologists, pharmacologists, physicians, researchers, and all others interested in the concepts about metabolic regulation will find this series of great value.

Table of Contents

  • Contributors


    Experiment, Hypothesis, and Theory in the Development of Concepts of Cell Membrane Structure

    Freeze-Etch Images of an Ion Transporting Membrane

    Membranal Ca++ Translocation and Cholinergic Receptor Activation

    Antibiotic A23187 as a Probe for the Study of Calcium and Magnesium Function in Biological Systems

    Regulation of Glucose Transport in Heart Muscle and Erythrocytes

    Carboxylic Ionophores as Mobile Carriers for Divalent Ions

    Regulation of the Translocation of Adenine Nucleotides across the Inner Mitochondrial Membrane by Long Chain Acyl CoA Esters

    NAD+ Redox State as Related to Mitochondrial and Cell Membranes

    Affinity Chromatographic Studies of the Insulin Receptivity Associated with Intact Fat Cells, Their Membranes, and Solubilized Extracts

    The Interaction of Insulin with Fat Cells: Its Physiological Significance

    The Role of Phospholipids in the Activation of Myocardial Adenylate Cyclase by Glucagon, Histamine, and the Catecholamines

    Characterization and Purification of the Cardiac β-Adrenergic Receptor

    Interaction between Na+-Dependent Transport Systems: Possible Mechanistic Significance

    The Stimulation of Corticosteroidogenesis in Isolated Rat Adrenal Cells by Agarose-ACTH

    Insulin, Glucocorticoid, and Enzyme Activity

    Insulin and the Mammary Epithelial Cell Membrane

    Glucagon Receptor

    Hormone Receptors, II. Biological Activity of Agarose-Glucagon, and Isolation of Glucagon-Binding Proteins from Solubilized Liver Plasma Membranes by Gel and Affinity Chromatography

    Studies on Factors Affecting the Adenylate Cyclase System of Rat Erythrocytes

    Ionic Effects in the Regulation of Sugar Transport in Muscle

    Subject Index

Product details

  • No. of pages: 444
  • Language: English
  • Copyright: © Academic Press 1972
  • Published: January 1, 1972
  • Imprint: Academic Press
  • eBook ISBN: 9780323141246

About the Editor

Myron Mehlman

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