The Role of DNA Damage and Repair in Cell Aging - 1st Edition - ISBN: 9780444504944, 9780080929415

The Role of DNA Damage and Repair in Cell Aging, Volume 4

1st Edition

Editors: B.A. Gilchrest V.A. Bohr
Hardcover ISBN: 9780444504944
eBook ISBN: 9780080929415
Imprint: Elsevier Science
Published Date: 9th March 2001
Page Count: 268
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Table of Contents

Introduction. Aging in mitotic and post-mitotic cells (J. Campisi, H.R. Warner). Age-associated changes in DNA repair and mutation rates (L. Grossman, S.-I. Moriwaki, S. Ray, R.E. Tarone, Qingyi Wei, K.H. Kraemer). Relationship of DNA repair capacity to species lifespan (R.W. Hart, A. Turturro, S.Y. Li). DNA base modifications in aging (J.W. Gaubatz). Models for studying genomic instability during aging (J. Vijg, H. Giese, M.E.T. Dollé). Effects of aging on gene specific repair (A. Richardson, ZhongMao Guo). Poly (ADP-RIBOSE) Polymerase and aging (D.S. Rosenthal, C.M. Simbulan-Rosenthal, Wen Fang Liu, M.E. Smulson). DNA instability, telomere dynamics, and cell transformation (R.J. Shmookler Reis, M.A. Shammas). Commitment signalling for apoptosis, or DNA repair and its relevance to aging and age-dependent diseases (E. Wang, R. Marcotte, H.T. Papaconstantinou, J. Papaconstantinou). DNA damage and its processing with aging: human premature aging syndromes as model systems (V.A. Bohr). Gene action at the Werner helicase locus: its role in the pathobiology of aging (J. Oshima, G.M. Martin, M.D. Gray, M. Poot, P.S. Rabinovitch). Inducible photoprotection in skin: evidence for a eukaryotic SOS response (M.S. Eller, B.A. Gilchrest). List of Contributors.


Description

Introduction. Aging in mitotic and post-mitotic cells (J. Campisi, H.R. Warner). Age-associated changes in DNA repair and mutation rates (L. Grossman, S.-I. Moriwaki, S. Ray, R.E. Tarone, Qingyi Wei, K.H. Kraemer). Relationship of DNA repair capacity to species lifespan (R.W. Hart, A. Turturro, S.Y. Li). DNA base modifications in aging (J.W. Gaubatz). Models for studying genomic instability during aging (J. Vijg, H. Giese, M.E.T. Dollé). Effects of aging on gene specific repair (A. Richardson, ZhongMao Guo). Poly (ADP-RIBOSE) Polymerase and aging (D.S. Rosenthal, C.M. Simbulan-Rosenthal, Wen Fang Liu, M.E. Smulson). DNA instability, telomere dynamics, and cell transformation (R.J. Shmookler Reis, M.A. Shammas). Commitment signalling for apoptosis, or DNA repair and its relevance to aging and age-dependent diseases (E. Wang, R. Marcotte, H.T. Papaconstantinou, J. Papaconstantinou). DNA damage and its processing with aging: human premature aging syndromes as model systems (V.A. Bohr). Gene action at the Werner helicase locus: its role in the pathobiology of aging (J. Oshima, G.M. Martin, M.D. Gray, M. Poot, P.S. Rabinovitch). Inducible photoprotection in skin: evidence for a eukaryotic SOS response (M.S. Eller, B.A. Gilchrest). List of Contributors.


Details

No. of pages:
268
Language:
English
Copyright:
© Elsevier Science 2001
Published:
Imprint:
Elsevier Science
eBook ISBN:
9780080929415
Hardcover ISBN:
9780444504944

Reviews

@from:G. Barja @qu:...This is a valuable book for specialists as well for those entering the field of DNA repair, who need a comprehensive understanding of its relationship to aging. @source:Aging Clinical and Experimental Research @from:S.I.S. Rattan @qu:...each chapter is well written and is highly informative. @source:Biogerontology @from:C.R. Malz @qu:...makes an important contribution to aging occurring at the level of individual cells and is useful for scientists trying desperately to keep-up with the larger field of research from which their own specializations derive. @source:Journal of Chemical Neuroanatomy


About the Editors

B.A. Gilchrest Editor

Affiliations and Expertise

Boston University, School of Medicine, Department of Dermatology, 609 Albany Street, J-507, Boston, MA 02118 USA

V.A. Bohr Editor

Affiliations and Expertise

Laboratory of Molecular Genetics, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224-6823, USA