The Role of 5-HT Systems on Memory and Dysfunctional Memory - 1st Edition - ISBN: 9780128008362, 9780128010839

The Role of 5-HT Systems on Memory and Dysfunctional Memory

1st Edition

Emergent Targets for Memory Formation and Memory Alterations

Authors: Alfredo Meneses
eBook ISBN: 9780128010839
Paperback ISBN: 9780128008362
Imprint: Academic Press
Published Date: 14th March 2014
Page Count: 92
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Drugs acting through 5-HT (5-hydroxytryptamine, or serotonin) systems modulate memory and its alterations, but the mechanisms by which they do so are poorly understood. Agonists and antagonists for 5-HT receptors, as well as serotonin uptake inhibitors, present promnesic (memory-promoting) and/or anti-amnesic effects under different conditions, and 5-HT receptors are also associated with neural changes. The Role of 5-HT Systems on Memory and Dysfunctional Memory: Emergent Targets for Memory Formation and Memory Alterations reviews and summarizes the most recent research related to 5-HT drugs and the mechanisms by which they effect alterations in memory. This latest evidence is reviewed in the context of memory deficits related to brain disorders, such as post-traumatic stress disorder, schizophrenia, post-stroke cognitive dysfunctions, Parkinson’s disease, and infection-induced memory impairments. Written by an expert in the field of memory, The Role of 5-HT Systems on Memory and Dysfunctional Memory provides an introduction to the latest research on 5-HT receptors and their contributions to the physiological and pharmacological basis of memory.

Key Features

  • Examines and summarizes the recent advances in drugs that act through the 5-HT systems
  • Reviews findings in the context of brain disorders that involve memory deficits
  • Covers emergent targets for memory formation and memory alterations


Academics and students studying memory, neuroscience, pharmacology

Table of Contents

  • Dedication
  • Acknowledgments
  • Chapter 1. Introduction
  • Chapter 2. 5-HT Systems and Neurobiological Markers Related to Memory Systems
  • Chapter 3. 5-HT Pathways, Receptors and Transporter: Memory Functions and Dysfunctions
    • 3.1 Protocols of Training/Testing, Memory Tasks, and Drugs
    • 3.2 Evidence Relating 5-HT Receptors and SERT to Memory
  • Chapter 4. 5-HT1A Receptor
  • Chapter 5. 5-HT1B Receptor
  • Chapter 6. 5-HT1E/1F Receptor
  • Chapter 7. 5-HT2A/2B/2C Receptor
  • Chapter 8. 5-HT3 Receptor
  • Chapter 9. 5-HT4 Receptor
  • Chapter 10. 5-HT5 Receptor
  • Chapter 11. 5-HT6 Receptor
    • 11.1 Neural Markers and Memory Tasks
  • Chapter 12. 5-HT7 Receptor
    • 12.1 SERT
  • Conclusions
  • References


No. of pages:
© Academic Press 2014
Academic Press
eBook ISBN:
Paperback ISBN:

About the Author

Alfredo Meneses

Affiliations and Expertise

Department of Pharmacobiology, CINVESTAV (Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional), Mexico


"There is an accumulating body of research suggesting that the serotonin system and serotonergic agents are involved in memory modulation. This book is a concise summary of this literature.  2 Stars - Score: 60" --Doody', October 2014

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