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Drugs acting through 5-HT (5-hydroxytryptamine, or serotonin) systems modulate memory and its alterations, but the mechanisms by which they do so are poorly understood. Agonists and antagonists for 5-HT receptors, as well as serotonin uptake inhibitors, present promnesic (memory-promoting) and/or anti-amnesic effects under different conditions, and 5-HT receptors are also associated with neural changes. The Role of 5-HT Systems on Memory and Dysfunctional Memory: Emergent Targets for Memory Formation and Memory Alterations reviews and summarizes the most recent research related to 5-HT drugs and the mechanisms by which they effect alterations in memory. This latest evidence is reviewed in the context of memory deficits related to brain disorders, such as post-traumatic stress disorder, schizophrenia, post-stroke cognitive dysfunctions, Parkinson’s disease, and infection-induced memory impairments. Written by an expert in the field of memory, The Role of 5-HT Systems on Memory and Dysfunctional Memory provides an introduction to the latest research on 5-HT receptors and their contributions to the physiological and pharmacological basis of memory.
- Examines and summarizes the recent advances in drugs that act through the 5-HT systems
- Reviews findings in the context of brain disorders that involve memory deficits
- Covers emergent targets for memory formation and memory alterations
Academics and students studying memory, neuroscience, pharmacology
- Chapter 1. Introduction
- Chapter 2. 5-HT Systems and Neurobiological Markers Related to Memory Systems
- Chapter 3. 5-HT Pathways, Receptors and Transporter: Memory Functions and Dysfunctions
- 3.1 Protocols of Training/Testing, Memory Tasks, and Drugs
- 3.2 Evidence Relating 5-HT Receptors and SERT to Memory
- Chapter 4. 5-HT1A Receptor
- Chapter 5. 5-HT1B Receptor
- Chapter 6. 5-HT1E/1F Receptor
- Chapter 7. 5-HT2A/2B/2C Receptor
- Chapter 8. 5-HT3 Receptor
- Chapter 9. 5-HT4 Receptor
- Chapter 10. 5-HT5 Receptor
- Chapter 11. 5-HT6 Receptor
- 11.1 Neural Markers and Memory Tasks
- Chapter 12. 5-HT7 Receptor
- 12.1 SERT
- No. of pages:
- © Academic Press 2014
- 14th March 2014
- Academic Press
- Paperback ISBN:
- eBook ISBN:
Department of Pharmacobiology, CINVESTAV (Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional), Mexico
"There is an accumulating body of research suggesting that the serotonin system and serotonergic agents are involved in memory modulation. This book is a concise summary of this literature. 2 Stars - Score: 60" --Doody's.com, October 2014
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