The Role of 5-HT Systems on Memory and Dysfunctional Memory

Drugs acting through 5-HT (5-hydroxytryptamine, or serotonin) systems modulate memory and its alterations, but the mechanisms by which they do so are poorly understood. Agonists and antagonists for 5-HT receptors, as well as serotonin uptake inhibitors, present promnesic (memory-promoting) and/or anti-amnesic effects under different conditions, and 5-HT receptors are also associated with neural changes. The Role of 5-HT Systems on Memory and Dysfunctional Memory: Emergent Targets for Memory Formation and Memory Alterations reviews and summarizes the most recent research related to 5-HT drugs and the mechanisms by which they effect alterations in memory. This latest evidence is reviewed in the context of memory deficits related to brain disorders, such as post-traumatic stress disorder, schizophrenia, post-stroke cognitive dysfunctions, Parkinson’s disease, and infection-induced memory impairments. Written by an expert in the field of memory, The Role of 5-HT Systems on Memory and Dysfunctional Memory provides an introduction to the latest research on 5-HT receptors and their contributions to the physiological and pharmacological basis of memory.

• Examines and summarizes the recent advances in drugs that act through the 5-HT systems
• Reviews findings in the context of brain disorders that involve memory deficits
• Covers emergent targets for memory formation and memory alterations

Academics and students studying memory, neuroscience, pharmacology

• Dedication
• Acknowledgments
• Chapter 1. Introduction
• Chapter 2. 5-HT Systems and Neurobiological Markers Related to Memory Systems
• Chapter 3. 5-HT Pathways, Receptors and Transporter: Memory Functions and Dysfunctions
  • 3.1 Protocols of Training/Testing, Memory Tasks, and Drugs
  • 3.2 Evidence Relating 5-HT Receptors and SERT to Memory
• Chapter 4. 5-HT1A Receptor
• Chapter 5. 5-HT1B Receptor
• Chapter 6. 5-HT1E/1F Receptor
• Chapter 7. 5-HT2A/2B/2C Receptor
• Chapter 8. 5-HT3 Receptor
• Chapter 9. 5-HT4 Receptor
• Chapter 10. 5-HT5 Receptor
• Chapter 11. 5-HT6 Receptor
  • 11.1 Neural Markers and Memory Tasks
• Chapter 12. 5-HT7 Receptor
  • 12.1 SERT
• Conclusions
• References