The Release of Catecholamines from Adrenergic Neurons focuses on the processes involved in determining the release of catecholamines from neurons, noting the influence of alcohols, analgesics, and acids in the release. The selection first discusses biochemical and ultrastructural studies of the mechanism of release, as well as release of constituents of noradrenergic vesicles upon nerve stimulation; constituents of noradrenergic vesicles; and mechanism of release. The book then takes a look at the role of calcium in catecholamine release from adrenergic nerve terminals and presynaptic adrenoceptors and regulation of release. Topics include calcium-dependent versus calcium-independent noradrenaline release; differences between the presynaptic and postsynaptic alpha-adrenoceptors; and influence of neuronal uptake of noradrenaline on the negative feedback mechanism mediated by presynaptic alpha-adrenoceptors. The publication reviews presynaptic muscarine receptors and inhibition of release, including muscarinic inhibition of noradrenaline release evoked by electrical stimulation of sympathetic nerves; effect of muscarinic agonists on noradrenaline releasing procedures independent of calcium ions; and possible physiological and pharmacological significance of the muscarinic inhibitory mechanism. The text also ponders on the role of prostaglandins, cyclic adenosine monophate, analgesics, peptides, acids, anesthetics, and alcohols in the release. The selection is a dependable reference for readers interested in the study of the release of catecholamines from adrenergic neurons.
Contents List of Contributors Preface A. Mechanism and Regulation of Nerve Stimulation Biochemical Studies of the Mechanism of Release Ultrastructural Studies of the Mechanism of Release The Role of Calcium in Catecholamine Release from Adrenergic Nerve Terminals Presynaptic Adrenoceptors and Regulation of Release Presynaptic Muscarine Receptors and Inhibition of Release Role of Prostaglandins and Cyclic Adenosine Monophate in Release Presynaptic Regulation of Release in the Central Nervous System B. Drugs Modifying Release During Nerve Stimulation Modification of Release by Adrenergic Neuron Blocking Agents and Agents That Alter the Action Potential Modification of Catecholamine Release by Narcotic Analgesics and Opioid Peptides Modification of Release by Lysergic Acid Diethylamide Modification of Catecholamine Release by Anaesthetics And Alcohols Modification of Release by Adenosine and Adenine Nucleotides C. Release Induced by Cations and Drugs Release Induced by Nicotinic Agonists Release Induced by Calcium Ionophores Release Induced by Alterations In Extracellular Potassium and Sodium and by Veratridine and Scorpion Venom Release Induced by Phenethylamines D. Clinical Physiology and Pharmacology Biochemical Assessment of Peripheral Adrenergic Activity The Clinical Pharmacology of Adrenergic Neuron Blocking Agents Index
- No. of pages:
- © Pergamon 1979
- 1st January 1979
- eBook ISBN: