The Release of Catecholamines from Adrenergic Neurons

The Release of Catecholamines from Adrenergic Neurons

1st Edition - January 1, 1979

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  • Editor: David M. Paton
  • eBook ISBN: 9781483188119

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Description

The Release of Catecholamines from Adrenergic Neurons covers the advances in understanding the mechanism of catecholamine release and other neurotransmitters from adrenergic neurons. This book is organized into four sections encompassing 18 chapters. The opening section surveys biochemical studies of the mechanism and regulation of nerve stimulation. This section examines the role of calcium, prostaglandins, and presynaptic adrenoceptors and muscarine receptors in catecholamine release. The next section describes the modification of catecholamine release by several drugs, including adrenergic neuron blocking agents, narcotic analgesics, opioid peptides, lysergic acid diethylamide, anesthetics, alcohols, and adenosine and adenine nucleotides. These topics are followed by discussions of catecholamine release induced by cations and other drugs, such as nicotinic agonists, calcium ionophores, veratridine, scorption venom, and phenethylamines. The final section deals with the biochemical assessment of peripheral adrenergic activity and the clinical pharmacology of adrenergic neuron blocking agents. This book is intended for pharmacologists, neurologists, researchers, and advanced students.

Table of Contents

  • Dedication

    LIST OF CONTRIBUTORS

    PREFACE

    A: Mechanism and Regulation of Nerve Stimulation

    Chapter 1: BIOCHEMICAL STUDIES OF THE MECHANISM OF RELEASE

    I HISTORICAL INTRODUCTION

    II CONSTITUENTS OF NORADRENERGIC VESICLES

    III RELEASE OF CONSTITUENTS OF NORADRENERGIC VESICLES UPON NERVE STIMULATION

    IV IMPLICATIONS OF THE BIOCHEMICAL STUDIES

    Chapter 2: ULTRASTRUCTURAL STUDIES OF THE MECHANISM OF RELEASE

    Publisher Summary

    I INTRODUCTION

    II STORAGE

    III SITE OF RELEASE

    IV MECHANISM OF RELEASE

    V SOURCE OF RELEASED NORADRENALINE

    VI FATE OF VESICLES AFTER RELEASE

    VII ORIGIN OF VESICLES

    VIII CONCLUSION

    Chapter 3: THE ROLE OF CALCIUM IN CATECHOLAMINE RELEASE FROM ADRENERGIC NERVE TERMINALS

    Publisher Summary

    I INTRODUCTION

    II REVIEW OF THE EVIDENCE THAT CALCIUM PLAYS A ROLE IN EXOCYTOSIS

    III CALCIUM-DEPENDENT VERSUS CALCIUM-INDEPENDENT NORADRENALINE RELEASE

    IV HOW DOES Ca ENTER THE TERMINALS?

    V WHAT IS THE ROLE OF CALCIUM IN VESICULAR EXOCYTOSIS?

    VI CALCIUM BUFFERING IN NERVE TERMINALS

    VII EXTRUSION OF CALCIUM FROM NERVE TERMINALS

    VIII SUMMARY AND CONCLUSION

    Acknowledgements

    Chapter 4: PRESYNAPTIC ADRENOCEPTORS AND REGULATION OF RELEASE

    Publisher Summary

    I INTRODUCTION

    II PRESYNAPTIC ALPHA-ADRENOCEPTORS

    III DIFFERENCES BETWEEN THE PRESYNAPTIC AND THE POSTSYNAPTIC ALPHA-ADRENOCEPTORS

    IV EVIDENCE FOR THE PRESYNAPTIC LOCATION OF THE ALPHA-ADRENOCEPTOR INVOLVED IN THE NEGATIVE FEEDBACK MECHANISM THAT REGULATES NORADRENALINE RELEASE DURING NERVE STIMULATION.

    V PHYSIOLOGICAL AND PHARMACOLOGICAL SIGNIFICANCE OF THE NEGATIVE FEEDBACK MECHANISM MEDIATED BY PRESYNAPTIC ALPHA-ADRENOCEPTORS

    VI INFLUENCE OF NEURONAL UPTAKE OF NORADRENALINE ON THE NEGATIVE FEEDBACK MECHANISM MEDIATED BY PRESYNAPTIC ALPHA-ADRENOCEPTORS

    VII EVIDENCE FOR THE PRESENCE OF PRESYNAPTIC BETA-ADRENOCEPTORS IN NORADRENERGIC NERVE ENDINGS

    VIII WORKING HYPOTHESIS FOR THE PARTICIPATION OF THE PRESYNAPTIC ALPHA AND BETA-ADRENOCEPTORS IN THE REGULATION OF NORADRENALINE RELEASE DURING NERVE STIMULATION

    IX INHIBITION OF STIMULATION-EVOKED RELEASE OF NORADRENALINE MEDIATED BY PRESYNAPTIC DOPAMINE RECEPTORS

    Chapter 5: PRESYNAPTIC MUSCARINE RECEPTORS AND INHIBITION OF RELEASE

    Publisher Summary

    I INTRODUCTION

    II MUSCARINIC INHIBITION OF NORADRENALINE RELEASE EVOKED BY ELECTRICAL STIMULATION OF SYMPATHETIC NERVES

    III MUSCARINIC INHIBITION OF NORADRENALINE RELEASE EVOKED BY NICOTINIC DRUGS

    IV MUSCARINIC INHIBITION OF NORADRENALINE RELEASE EVOKED BY A HIGH POTASSIUM ION CONCENTRATION

    V EFFECT OF MUSCARINIC AGONISTS ON NORADRENALINE RELEASING PROCEDURES INDEPENDENT OF CALCIUM IONS

    VI EFFECT OF METHACHOLINE ON THE RELEASE OF AN ADRENERGIC FALSE TRANSMITTER

    VII INDIRECT EVIDENCE FOR MUSCARINIC MODULATION OF TRANSMITTER RELEASE

    VIII THE TYPE OF MUSCARINE RECEPTOR INVOLVED IN THE INHIBITORY EFFECT

    IX THE RELATIONSHIP BETWEEN MUSCARINIC INHIBITION AND DEPENDENCE ON CALCIUM FOR RELEASE

    X POSSIBLE PHYSIOLOGICAL AND PHARMACOLOGICAL SIGNIFICANCE OF THE MUSCARINIC INHIBITORY MECHANISM

    Chapter 6: ROLE OF PROSTAGLANDINS AND CYCLIC ADENOSINE MONOPHATE IN RELEASE

    Publisher Summary

    I INTRODUCTION

    II PROSTAGLANDINS AND RELEASE OF NORADRENALINE

    III CYCLIC ADENOSINE MONOPHATE AND NORADRENALINE SECRETION

    IV SUMMARY AND CONCLUSIONS

    Chapter 7: PRESYNAPTIC REGULATION OF RELEASE IN THE CENTRAL NERVOUS SYSTEM

    Publisher Summary

    I INTRODUCTION, DEFINITIONS AND SCOPE

    II DETERMINATION OF CATECHOLAMINE RELEASE

    III REGULATION OF NORADRENALINE RELEASE

    IV REGULATION OF DOPAMINE RELEASE

    V CONCLUDING REMARKS

    B: Drugs Modifying Release During Nerve Stimulation

    Chapter 8: MODIFICATION OF RELEASE BY ADRENERGIC NEURON BLOCKING AGENTS AND AGENTS THAT ALTER THE ACTION POTENTIAL

    Publisher Summary

    I INTRODUCTION

    II CLASSICAL ADRENERGIC NEURON BLOCKING AGENTS

    III MISCELLANEOUS AGENTS WITH ADRENERGIC NEURON BLOCKING PROPERTIES

    IV AGENTS AND IONS AFFECTING THE ACTION POTENTIAL

    V SUMMARY

    Chapter 9: MODIFICATION OF CATECHOLAMINE RELEASE BY NARCOTIC ANALGESICS AND OPIOID PEPTIDES

    Publisher Summary

    I INTRODUCTION

    II NORADRENALINE RELEASE

    III NORADRENALINE UPTAKE

    IV OPIOID PEPTIDES

    V MULTIPLE OPIATE RECEPTORS

    VI MECHANISM OF ACTION

    Chapter 10: MODIFICATION OF RELEASE BY LYSERGIC ACID DIETHYLAMIDE

    Publisher Summary

    I INTRODUCTION

    II CONTRACTILE EFFECTS OF LSD

    III INHIBITION OF NERVE-INDUCED CONTRACTION BY LSD

    IV COMPARISON OF THE EFFECTS OF LSD ON THE NERVE-INDUCED OVERFLOW OF [3H]NORADRENALINE AND ON THE ACCOMPANYING CONTRACTILE RESPONSES

    Chapter 11: MODIFICATION OF CATECHOLAMINE RELEASE BY ANAESTHETICS AND ALCOHOLS

    Publisher Summary

    I INTRODUCTION

    II EFFECTS OF ALCOHOLS

    III EFFECTS OF INHALATION ANAESTHETICS

    IV EFFECTS OF INTRAVENOUS ANAESTHETICS

    V POSSIBLE SITE AND MECHANISM OF ACTION UNDERLYING THE INHIBITION OF STIMULATED RELEASE

    Chapter 12: MODIFICATION OF RELEASE BY ADENOSINE AND ADENINE NUCLEOTIDES

    Publisher Summary

    I INTRODUCTION

    II EFFECTS OF ADENINE NUCLEOTIDES AND ADENOSINE ON NORADRENALINE RELEASE

    III SITE OF ACTION

    IV MECHANISM OF ACTION

    V SIGNIFICANCE OF PRESYNAPTIC ‘PURINERGIC’ RECEPTORS

    VI CONCLUSION

    Acknowledgements

    C: Release Induced by Cations and Drugs

    Chapter 13: RELEASE INDUCED BY NICOTONIC AGONISTS

    Publisher Summary

    I INTRODUCTION

    II BASIC EVIDENCE

    III MECHANISM OF RELEASE

    IV EFFECTS OF DRUGS AND IONS ON NICOTINIC RELEASE

    V BIOLOGICAL OCCURRENCE AND DISTRIBUTION OF NICOTINE RECEPTORS

    VI SPECULATIONS ON A PHYSIOLOGICAL SIGNIFICANCE

    VII TOXICOLOGICAL ASPECTS

    Chapter 14: RELEASE INDUCED BY CALCIUM IONOPHORES

    Publisher Summary

    I INTRODUCTION

    II CALCIUM IONOPHORES

    III CATECHOLAMINE RELEASE BY THE CALCIUM IONOPHORES

    Chapter 15: RELEASE INDUCED BY ALTERATIONS IN EXTRACELLULAR POTASSIUM AND SODIUM AND BY VERATRIDINE AND SCORPION VENOM

    Publisher Summary

    I INTRODUCTION

    II RELEASE INDUCED BY POTASSIUM

    III RELEASE INDUCED BY VERATRIDINE AND BY SCORPION VENOM

    IV RELEASE PRODUCED BY PROCEDURES THAT INHIBIT SODIUM PUMPING

    V RELEASE PRODUCED BY LOWERING THE EXTERNAL SODIUM CONCENTRATION

    Chapter 16: RELEASE INDUCED BY PHENETHYLAMINES

    Publisher Summary

    I INTRODUCTION

    II IS AMINE EFFLUX CARRIER-MEDIATED?

    III ARE THERE EXTRAVESICULAR BINDING SITES FOR NORADRENALINE?

    IV UPTAKE AND RETENTION OF TYRAMINE BY AND IN ISOLATED STORAGE VESICLES

    V METABOLISM OF THE NORADRENALINE RELEASED BY INDIRECTLY ACTING SYMPATHOMIMETIC AMINES

    VI CONCLUSIONS

    D: Clinical Physiology and Pharmacology

    Chapter 17: BIOCHEMICAL ASSESSMENT OF PERIPHERAL ADRENERGIC ACTIVITY

    Publisher Summary

    I INTRODUCTION

    II URINARY EXCRETION OF CATECHOLAMINES

    III EXCRETION OF URINARY METABOLITES

    IV MEASUREMENT OF PLASMA LEVELS OF ADRENALINE AND NORADRENALINE

    V SIGNIFICANCE OF PLASMA CATECHOLAMINE LEVELS

    VI SERUM DOPAMINE-β-HYDROXYLASE

    VII CONCLUSION

    Chapter 18: THE CLINICAL PHARMACOLOGY OF ADRENERGIC NEURON BLOCKING AGENTS

    Publisher Summary

    I INTRODUCTION

    II MECHANISM OF ACTION

    III HEMODYNAMIC EFFECTS

    IV DRUG INTERACTIONS

    V PHARMACOKINETICS

    VI RELATIONSHIP OF PLASMA CONCENTRATION TO ADRENERGIC NEURON BLOCKADE

    VII RESISTANCE TO TREATMENT WITH ADRENERGIC NEURON BLOCKING AGENTS

    VIII CONCLUSIONS

    INDEX

Product details

  • No. of pages: 406
  • Language: English
  • Copyright: © Pergamon 1979
  • Published: January 1, 1979
  • Imprint: Pergamon
  • eBook ISBN: 9781483188119

About the Editor

David M. Paton

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