The Receptors

Contributors

Preface

Contents of Previous Volume

Chapter 1 The Vitamin D Receptor

I. Introduction

II. Discovery of the Receptor Proteins for l,25-(OH)2D3

III. Biochemical and Physical Properties of the l,25-(OH)2D3 Receptor

IV. Mechanism of Action of the l,25-(OH)2D3 Receptor

V. Regulation of Receptor Number

VI. Purification of Chick Intestinal l,25-(OH)2D3 Receptor

VII. Antibodies to Chick Intestinal l,25-(OH)2D3 Receptor

VIII. Conclusions

References

Chapter 2 On Experimental Discrimination Between Alternative Mechanistic Models for the Receptor-Mediated Stimulation of Adenylate Cyclase

I. Introduction

II. General Assumptions, Definitions, and Nomenclature

III. Is the Receptor a Catalyst or a Reactant?

IV. What Are the Functional Relationships Between R, N, and C, and How Are They Affected by Agonist and Guanine Nucleotide?

V. Summary

References

Chapter 3 The Role of Microaggregation in Hormone-Receptor-Effector Interactions

I. Introduction

II. The GnRH Receptor

III. Evidence That Microaggregation Plays a Key Role in Other Antibody-Receptor-Effector Systems

IV. The Adenylate Cyclase System

V. Receptor-Effector Interactions Revisited

References

Chapter 4 The Ah Receptor: A Biochemical and Biologic Perspective

I. Introduction

II. Biochemical Characterization of the Ah Receptor

III. Biology of the Ah Receptor

IV. Mechanism(s) of Action: Cell Biology and Biochemical Approaches

V. Concluding Comments

References

Chapter 5 Interactions of Animal Viruses with Cell Surface Receptors

I. Introduction

II. Viral Attachment Proteins

III. Identification of Cell Surface Receptors

IV. Cell Surface Receptor Determinants of Animal Viruses

V. Role of Receptors in Viral Penetration

VI. Role of Viral Receptors in Host Range and Tissue Tropism

VII. Summary and Future Perspectives

References

Chapter 6 Studies on Insulin Receptors: Implications for Insulin Action

I. Introduction

II. Receptor Purification

III. Receptor Structure

IV. Glycoprotein Nature of the Insulin Receptor

V. Tyrosyl Phosphorylation

VI. Interrelations of the Insulin Receptor to Other Receptor Structures

VII. Receptor-Mediated Internalization and Degradation of Insulin

VIII. Down-Regulation

IX. Possible Involvement of Cytoskeletal Elements in Insulin Action

X. Receptor Valence

XI. Nonlinear Scatchard Plots

XII. Possible Role for Receptor Cross-Linking and for Non-Insulin-Binding Regulatory Glycoprotein

XIII. Transmembrane Signaling

References

Chapter 7 Size of Neurotransmitter Receptors as Determined by Radiation Inactivation-Target Size Analysis

I. Introduction

II. Radiation Inactivation-Target Size Analysis

III. Conclusions and Avenues for Further Study

References

Chapter 8 α2-Adrenergic Receptors: Apparent Interaction with Multiple Effector Systems

I. Historical Perspective and Introduction

II. Identification of α-Adrenergic Receptors

III. Properties of α2-Adrenergic Receptors Linked to Inhibition of Adenylate Cyclase

IV. Postulated Mechanisms by Which α2-Adrenergic Agents Inhibit Adenylate Cyclase Activity

V. Postulated Mechanisms by Which α2-Adrenergic Agents Elicit Physiological Effects

VI. Summary

References

Chapter 9 Protein Glycosylation and Receptor-Ligand Interactions

I. Introduction

II. Carbohydrates in Determining Specificity

III. General Features of Glycoproteins

IV. Structural Organization of the Glycoprotein Hormones

V. Biological Properties of the Glycoprotein Hormones

VI. Experimental Approaches to Studying the Role of Carbohydrate Units

VII. Role of Carbohydrate in the Recognition and Uptake of Glycoprotein by Cells

VIII. Glycoprotein Hormone-Receptor Interactions

IX. Role of Carbohydrate in Receptor Assembly and Function

X. Concluding Remarks

References

Chapter 10 Role of Steroid Hormone Receptors in Development and Puberty

I. Introduction

II. Glucocorticoid Receptors

III. Androgen Receptors

IV. Estrogen Receptors

V. Progesterone Receptors

VI. Gonadal Steroid Receptors and Brain Development

VII. Puberty

References

Chapter 11 Functions and Regulation of Cell Surface Receptors in Cultured Leydig Tumor Cells

I. Introduction

II. . Differentiated Function of MA-10 Cells

III. Interaction of hCG with MA-10 Cells

IV. Interaction of mEGF with MA-10 Cells

V. Mechanisms Involved in the Homologous and Heterologous Down-Regulation of hCG Receptors Are Different

VI. Regulation of Steroidogenic Responses by mEGF and hCG

VII. Regulation of Steroidogenic Responses by Cholesterol Availability: The Role of Low-Density Lipoprotein

VIII. Summary

References

Chapter 12 Somatostatin Receptors in Endocrine Cells

I. Introduction

II. Characteristics of Somatostatin Binding in Endocrine Cells

III. Modulation of Somatostatin Binding by Hormones and Secretagogues

IV. Biological Significance of Somatostatin-Receptor Translocation

References

Index