The Proteins Pt 4

The Proteins Pt 4

3rd Edition - January 1, 1979

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  • Editor: Hans Neurath
  • eBook ISBN: 9780323162043

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Description

The Proteins, Third Edition, Volume IV is a four-chapter text that explores the unifying concepts of protein chemistry and the methods of analysis that can be applied to most proteins. The first chapter deals with the biological origins and subsequent evolution of proteins. This chapter also provides the various procedures for comparing amino acid sequences and for establishing the relatedness of protein structures. A discussion on gene duplication as a principal vehicle of evolutionary change is also included in this chapter. Chapter 2 focuses on chromosomal proteins, such as those proteins associated with the genetic material of eukaryotic organisms, specifically the protamines, the histones, and the ""nonhistone"" proteins. Chapter 3 is devoted to contractile proteins of muscle. This chapter describes the molecular processes whereby chemical energy is converted into the mechanical energy required for the propulsion of living creatures. The structure and function of the individual proteins of the contractile apparatus and their organization as evidenced by light and electron microscopy and by X-ray analysis are also covered. Chapter 4 deals with collagen, an important constituent of the extracellular connective tissues in animals and one of the most abundant proteins. This chapter emphasizes the biosynthesis of collagen fibrils. Organic chemists and researchers, teachers and undergraduate students will find this book invaluable.

Table of Contents


  • List of Contributors

    Preface

    Contents of Other Volumes

    Chapter 1. Protein Evolution

    I. Introduction

    II. Genetic Basis of Amino Acid Replacements

    III. Evolutionary Fixation of Amino Acid Replacements

    IV. Comparing Amino Acid Sequences

    V. Gene Duplication

    VI. The Search for Common Ancestors

    VII. Animal Structural Proteins and Other Highly Repetitive Sequences

    VIII. Concluding Remarks

    References

    Chapter 2. Chromosomal Proteins

    I. General Introduction

    II. Fish Sperm Protamines

    III. Histones

    IV. Protamine-Like Proteins

    V. Nonhistone Chromosomal Proteins

    References

    Chapter 3. Contractile Proteins of Muscle

    I. Introduction

    II. Organization of the Myofibril in Vertebrate Striated Muscle

    III. The Thick Filaments: Structure and Function

    IV. Aggregation of Myosin and Its Proteolytic Fragments

    V. The Structure of Myosin

    VI. The C-Protein

    VII. Structure of the Thin Filaments

    VIII. The Structure of G-Actin

    IX. The Regulatory Proteins

    X. The M-Line Proteins

    XI. The Z-Line Proteins

    XII. Paramyosin

    XIII. The Mechanism of Muscular Contraction in Striated Muscle

    References

    Chapter 4. The Chemistry and Biology of Collagen

    I. Introduction

    II. Identification, Distribution, and Function

    III. Procollagen

    IV. Chemical Composition of Collagen

    V. Primary Structure of Collagen

    VI. Covalent Interchain Cross-Links in Collagen

    VII. Molecular Conformation

    VIII. Fibril Structure

    IX. Immunochemistry

    X. Hydroxylation of Peptidyl Proline and Lysine

    XI. Degradation of Collagen by Enzymes from Animal Sources

    XII. Heritable Disorders of Collagen Synthesis

    XIII. Concluding Remarks

    References

    Author Index

    Subject Index




Product details

  • No. of pages: 696
  • Language: English
  • Copyright: © Academic Press 1979
  • Published: January 1, 1979
  • Imprint: Academic Press
  • eBook ISBN: 9780323162043

About the Editor

Hans Neurath

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