The Proteins Composition, Structure, and Function V1

The Proteins Composition, Structure, and Function V1

2nd Edition - January 1, 1963

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  • Editor: Hans Neurath
  • eBook ISBN: 9780323161381

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The Proteins: Composition, Structure, and Function, Second Edition, Volume I explores the quantitative relationships between protein composition, structure, and function. This book is composed of six chapters that cover the rapid and fundamental advances in understanding protein chemistry. This book outlines first the quantitative procedures and various methods suitable for the determination of amino acids found as constituents of naturally occurring peptides and as free amino acids in tissues and body fluids. These topics are followed by a discussion on some of the aspects of peptide chemistry, which appear significant in relation to peptides possessing physiological activity. The next chapter considers protein synthesis that represents the sequences of chemical reactions whereby amino acids are assembled in biological systems to produce proteins. This volume also examines the correlation of structure with function; the mechanisms of control of protein biosynthesis; the exact role of intramolecular interactions in the determination of tertiary structure; and the colinearity of genetic “maps” with amino acid sequences. A chapter describes the methods of analysis and reactions of sulfhydryl, disulfide, and thiol ester groups in proteins, as well as the evidence relating to the functions of these sulfur groups in proteins. The final chapter looks into the models and theories for the noncovalent bond interactions in proteins. This book is of value to organic chemists, biochemists, and researchers in the protein-related fields.

Table of Contents

  • List of Contributors


    Contents of Volume II

    Chapter 1 Amino Acid Analysis of Peptides and Proteins

    I. General Introduction

    II. Preparation of Material for Analysis

    III. Evolution of Amino Acid Analysis—From Macrochemistry to Microchemistry

    IV. Analysis of Intact Protein

    V. Estimation of Free Amino Acids

    VI. Methods of Protein Hydrolysis

    VII. Conclusions and Recapitulation


    Addendum to Chapter 1 Amino Acid Composition of Certain Proteins



    Chapter 2 Synthesis and Function of Peptides of Biological Interest

    I. Introduction

    II. Synthesis of Peptides

    III. Synthetic Pituitary Hormones

    IV. Biologically Active Protein Fragments

    V. Structure-Function Relations

    VI. Specificity of Peptides


    Chapter 3 Chemical Aspects of Protein Synthesis

    I. Introduction

    II. Experimental Criteria of Protein Synthesis

    III. "Activation" of Amino Acids

    IV. Specificity of Amino Acid Incorporation into Peptide Chains

    V. Amino Acid Incorporation by Nonmicrosomal Subcellular Elements

    VI. Are Peptides Intermediates in Protein Synthesis?

    VII. Special Aspects of the Biosynthesis of Individual Proteins

    VIII. Conclusion


    Chapter 4 Concepts and Experimental Approaches in the Determination of the Primary Structure of Proteins

    I. Introduction

    II. Methods for the Determination of the Covalent Structure of Proteins

    III. Primary Structures of Specific Proteins

    IV. Future Development of Sequence Analysis


    Chapter 5 Intramolecular Bonds in Proteins. I. The Role of Sulfur in Proteins

    I. Introduction

    II. Analytical Methods

    III. The Reactions of Sulfhydryl, Disulfide, and Thio Ether Groups in Proteins

    IV. The Functions of Sulfhydryl, Disulfide, and Thio Ether Groups in Proteins


    Chapter 6 Intramolecular Bonds in Proteins. II. Noncovalent Bonds

    I. Introduction

    II. Nature of Noncovalent Interactions

    III. Statistical Thermodynamic Theories of Noncovalent Interactions

    IV. Denaturation

    V. Influence of Noncovalent Interactions on Other Protein Reactions

    VI. Conclusions

    Appendix A. Matrix Method for Evaluation of Lifson-Roig (LR) Partition Function

    Appendix B. Partition Functions for the Structure of Water and Aqueous Hydrocarbon Solutions

    Appendix C. Peller's Theory for the Helix-Coil Transition

    Author Index

    Subject Index

Product details

  • No. of pages: 680
  • Language: English
  • Copyright: © Academic Press 1963
  • Published: January 1, 1963
  • Imprint: Academic Press
  • eBook ISBN: 9780323161381

About the Editor

Hans Neurath

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