This volume of Progress in Molecular Biology and Translational Science discusses cutting-edge research of proteasomes and proteasome-associated proteins and cellular systems. The volume is split into two sections. The first part discusses the current knowledge of the structure, function, and regulation of the proteasomal system. The second part describes the role of the proteasome in aging and disease.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Molecular biologists and researchers of proteasomes

Table of Contents

  1. Structure of the Proteasome
  2. Tobias Jung and Tilman Grune

  3. Structure and Function of the Ubiquitin-Proteasome System: Modulation of Components
  4. Niki Chondrogianni and Efstathios S. Gonos

  5. Immunoproteasomes: Structure, Function, and Antigen Presentation
  6. Deborah A. Ferrington and Dale S. Gregerson

  7. Interactions of the Proteasomal System with Chaperones – Protein Triage and Protein Quality Control
  8. Marc Kästle and Tilman Grune

  9. Proteasome Inhibitors
  10. Boris Cvek

  11. Degradation of Damaged Proteins - The Main Function of the 20S Proteasome
  12. Andrew. M. Pickering and Kelvin. J. A. Davies

  13. Changes of the Proteasomal System During the Aging Process
  14. Martin A. Baraibar and Bertrand Friguet

  15. Proteasome and Cancer
  16. Betul Catalgol

  17. The Ubiquitin Proteasome System and Cardiovascular Disease.
  18. Saul R. Powell, Joerg Herrmann, Amir Lerman, Cam Patterson, Xuejun Wang

  19. Role of the Ubiquitin-Proteasome in Protein Quality Control and Signaling: Implication in the Pathogenesis of Eye Diseases
  20. Fu Shang and Allen Taylor

  21. Proteasome and Neurodegeneratıve Dıseases

Betul Catalgol and Tilman Grune


No. of pages:
© 2012
Academic Press
Print ISBN:
Electronic ISBN:


Praise for the series:
"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal