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The Plasticity of Sex - 1st Edition - ISBN: 9780128159682, 9780128159699

The Plasticity of Sex

1st Edition

The Molecular Biology and Clinical Features of Genomic Sex, Gender Identity and Sexual Behavior

Editor: Marianne Legato
Paperback ISBN: 9780128159682
eBook ISBN: 9780128159699
Imprint: Academic Press
Published Date: 20th May 2020
Page Count: 318
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The Plasticity of Sex: The Molecular Biology and Clinical Features of Genomic Sex, Gender Identity and Sexual Behavior provides a comprehensive view on the development of human sexuality. As there has been a crescendo of interest over the past several decades about the nature and diversity of human sexuality, this reference brings the evidence-based research into one place. The emergence of issues surrounding gender identity, genital ambivalence and the transition from one sex to another is striking, with the public and treating physicians alike clamoring for an evidence-based, comprehensive treatment of human sexuality and all its variations.

This is a must-have reference for biomedical researchers in endocrinology, neuroscience, development biology, medical students, residents, and practicing physicians from all medical areas.

Key Features

  • Discusses the role of biology in gender identity from research in genetics, endocrinology and neuroscience
  • Addresses important health disparities and how to address them when treating the transgender patient
  • Reviews evidence-based information on the biological basis and impact of environmental and hormonal factors at different life stages
  • Outlines schema for treating variations in the sexuality and sexual function of the individual patient


Biomedical researchers in endocrinology, neuroscience, development biology; medical students, residents, and practicing physicians from all medical areas

Table of Contents



1. What determines biological sex?
Marianne J. Legato

2. Disorders of sex development
Marianne J. Legato

3. The sexual brain
Marianne J. Legato

4. The transgender individual
Marianne J. Legato

5. Homosexuality: the biological basis of differences in sexual orientation
Marianne J. Legato

6. The strong heritability of gender dysphoria
Frederick L. Coolidge and Ari Stillman

7. 5α-Reductase deficiency syndrome: the impact of androgens on gender identity and gender role
Michael E. Bales, Yuan-Shan Zhu and Julianne Imperato-McGinley

8. Biological basis of gender identity
Alessandra Daphne Fisher and Carlotta Cocchetti

9. Congenital adrenal hyperplasia as a model to explore gender fluidity in early life; particularly 46,XX patients with male external genitalia
Kanthi Bangalore Krishna, Christopher P. Houk, Fauzia Mohsin and Peter A. Lee

10. Testosterone treatment for transgender (trans) men
Michael S. Irwig

11. Transgender care
Abhilasha Singh and Adrian Dobs

12. Fertility preservation for transgender individuals
Kenny A. Rodriguez-Wallberg

13. Breast imaging in transgender individuals
Tamar Reisman

14. Protecting children with intersex traits: legal, ethical, and human rights considerations
Katharine B. Dalke, Arlene B. Baratz and Julie A. Greenberg

15. Transphobic discrimination and health
Lisa R. Miller

16. Societal experiences of lesbian, gay, bisexual, and transgender people
Michael Fuchs and Jennifer Potter

17. Implementing LGBTQ curricula into health professions education
Andrew D. Hollenbach, Bernard Landry-Wegener and Robin English



No. of pages:
© Academic Press 2020
20th May 2020
Academic Press
Paperback ISBN:
eBook ISBN:

About the Editor

Marianne Legato

Dr. Marianne Legato, Professor Emerita of Clinical Medicine at Columbia University is an internationally known academic physician, author, lecturer, and specialist in gender-specific medicine. She is founding member of the International Society for Gender Medicine and also the founder and director of The Partnership for Gender-Specific Medicine at Columbia University and its next iteration, The Foundation for Gender-Specific Medicine. She has published extensively on gender and sex specific medicine, both scientifically and for the lay public. She is also the founding editor of the journal Gender Medicine, and the journal Gender and the Genome, published for the scientific community. In 1992, Dr. Legato won the American Heart Association’s Blakeslee Award for the best book written for the lay public on cardiovascular disease. She is a practicing internist in New York City and has been listed each year in New York Magazine’s "Best Doctors" since the feature’s inception in 1993.

Affiliations and Expertise

Professor Emerita of Clinical Medicine at Columbia University; New York, NY, U.S.A.

Ratings and Reviews