The Plasticity of Sex

The Plasticity of Sex

The Molecular Biology and Clinical Features of Genomic Sex, Gender Identity and Sexual Behavior

1st Edition - May 19, 2020

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  • Editor: Marianne Legato
  • eBook ISBN: 9780128159699
  • Paperback ISBN: 9780128159682

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The Plasticity of Sex: The Molecular Biology and Clinical Features of Genomic Sex, Gender Identity and Sexual Behavior provides a comprehensive view on the development of human sexuality. As there has been a crescendo of interest over the past several decades about the nature and diversity of human sexuality, this reference brings the evidence-based research into one place. The emergence of issues surrounding gender identity, genital ambivalence and the transition from one sex to another is striking, with the public and treating physicians alike clamoring for an evidence-based, comprehensive treatment of human sexuality and all its variations. This is a must-have reference for biomedical researchers in endocrinology, neuroscience, development biology, medical students, residents, and practicing physicians from all medical areas. Winner of the 2021 PROSE Award in Biomedicine from the Association of American Publishers!

Key Features

  • Discusses the role of biology in gender identity from research in genetics, endocrinology and neuroscience
  • Addresses important health disparities and how to address them when treating the transgender patient
  • Reviews evidence-based information on the biological basis and impact of environmental and hormonal factors at different life stages
  • Outlines schema for treating variations in the sexuality and sexual function of the individual patient


Biomedical researchers in endocrinology, neuroscience, development biology; medical students, residents, and practicing physicians from all medical areas

Table of Contents

  • 1. What determines biological sex?
    Marianne J. Legato
    2. Disorders of sex development
    Marianne J. Legato
    3. The sexual brain
    Marianne J. Legato
    4. The transgender individual
    Marianne J. Legato
    5. Homosexuality: the biological basis of differences in sexual orientation
    Marianne J. Legato
    6. The strong heritability of gender dysphoria
    Frederick L. Coolidge and Ari Stillman
    7. 5α-Reductase deficiency syndrome: the impact of androgens on gender identity and gender role
    Michael E. Bales, Yuan-Shan Zhu and Julianne Imperato-McGinley
    8. Biological basis of gender identity
    Alessandra Daphne Fisher and Carlotta Cocchetti
    9. Congenital adrenal hyperplasia as a model to explore gender fluidity in early life; particularly 46,XX patients with male external genitalia
    Kanthi Bangalore Krishna, Christopher P. Houk, Fauzia Mohsin and Peter A. Lee
    10. Testosterone treatment for transgender (trans) men
    Michael S. Irwig
    11. Transgender care
    Abhilasha Singh and Adrian Dobs
    12. Fertility preservation for transgender individuals
    Kenny A. Rodriguez-Wallberg
    13. Breast imaging in transgender individuals
    Tamar Reisman
    14. Protecting children with intersex traits: legal, ethical, and human rights considerations
    Katharine B. Dalke, Arlene B. Baratz and Julie A. Greenberg
    15. Transphobic discrimination and health
    Lisa R. Miller
    16. Societal experiences of lesbian, gay, bisexual, and transgender people
    Michael Fuchs and Jennifer Potter
    17. Implementing LGBTQ curricula into health professions education
    Andrew D. Hollenbach, Bernard Landry-Wegener and Robin English

Product details

  • No. of pages: 318
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: May 19, 2020
  • Imprint: Academic Press
  • eBook ISBN: 9780128159699
  • Paperback ISBN: 9780128159682

About the Editor

Marianne Legato

Dr. Marianne Legato, Professor Emerita of Clinical Medicine at Columbia University is an internationally known academic physician, author, lecturer, and specialist in gender-specific medicine. She is founding member of the International Society for Gender Medicine and also the founder and director of The Partnership for Gender-Specific Medicine at Columbia University and its next iteration, The Foundation for Gender-Specific Medicine. She has published extensively on gender and sex specific medicine, both scientifically and for the lay public. She is also the founding editor of the journal Gender Medicine, and the journal Gender and the Genome, published for the scientific community. In 1992, Dr. Legato won the American Heart Association’s Blakeslee Award for the best book written for the lay public on cardiovascular disease. She is a practicing internist in New York City and has been listed each year in New York Magazine’s "Best Doctors" since the feature’s inception in 1993.

Affiliations and Expertise

Emerita Professor, Clinical Medicine, Columbia University College of Physicians & Surgeons and Adjunct Professor, Medicine at Johns Hopkins Medical School

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