The Plasma Proteins V4

Structure, Function, and Genetic Control

2nd Edition - December 19, 1984
Editor: Frank Putnam
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 6 1 7 3 - 2

The Plasma Proteins: Structure, Function, and Genetic Control is a systematic account of the structure, function, and genetic control of plasma proteins. Advances in the… Read more

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The Plasma Proteins: Structure, Function, and Genetic Control is a systematic account of the structure, function, and genetic control of plasma proteins. Advances in the characterization and posttranslational modification of plasma proteins are discussed, along with the structure of a variety of plasma proteins such as serum albumin, glycoproteins, and serum lipoproteins, and immunoglobulins. Comprised of six chapters, this volume begins with a review of progress in plasma proteins, focusing on their three-dimensional structure, characterization, and microheterogeneity as well as genetic polymorphism and chromosomal mapping. The second chapter gives a comprehensive summary of the structure of nearly 100 proteins, from serum albumin and glycoproteins to serum lipoproteins, thyroxine-binding proteins, and immunoglobulins. The reader is then introduced to human plasma proteins of unknown function, together with high-resolution two-dimensional electrophoretic mapping. The remaining chapters explore developments in the structural study of carbon hydrates; synthesis, structure, and function of the oligosaccharides of plasma glycoproteins; and the evolution of the vertebrate plasma proteins. This monograph will be of interest to molecular biologists and biochemists.

Contributors

Preface

Contents of Other Volumes

1 Progress in Plasma Proteins

I. Introduction

II. Characterization of the Plasma Proteins

III. Microheterogeneity and Posttranslational Modification of Plasma Proteins

IV. Panoramic View of the Plasma Proteins

V. Primary Structure of the Plasma Proteins

VI. Three-Dimensional Structure and Ultrastructure of Plasma Proteins

VII. Hereditary Deficiencies and Genetic Polymorphism of Human Plasma Proteins

VIII. Chromosomal Mapping and Genomic Organization of Human Plasma Proteins

IX. Conclusion

References

2 Alpha, Beta, Gamma, Omega—The Structure of the Plasma Proteins

I. Introduction

II. Serum Albumin and α-Fetoprotein

III. Thyroxine-Binding Proteins

IV. α-Glycoproteins

V. β-Glycoproteins

VI. C-Reactive Protein and Serum Amyloid Proteins

VII. Minor Low-Molecular-Weight Proteins with y or Basic Mobility and Unknown Function

VIII. Serum Lipoproteins

IX. The Complement System

X. Blood Coagulation Proteins

XI. Immunoglobulins

References

3 Human Plasma Proteins of Unknown Function

I. Introduction

II. Description of Human Plasma Proteins of Unknown Function

III. Low-Molecular-Weight Trace Proteins with Basic or y Mobility and Unknown Function

IV. Description of Passenger Proteins with Unknown Function

References

4 High-Resolution Two-Dimensional Electrophoretic Mapping of Plasma Proteins

I. Introduction

II. Two-Dimensional Map of Plasma Proteins

III. Microheterogeneity

IV. Genetic Polymorphism

V. Immunoglobulins

VI. The Future of Protein Mapping

References

5 The Oligosaccharides of Plasma Glycoproteins: Synthesis, Structure, and Function

I. Introduction

II. General Features

III. Regulation of Glycosylation

IV. Function

V. Immunoglobulins

VI. Future Directions

References

6 Evolution of the Vertebrate Plasma Proteins

I. Introduction

II. Four Major Plasma Proteins

III. Two Other Plasma Proteins

IV. Lipoproteins

V. Protease Inhibitors

VI. Complement Proteins

VII. Vertebrate Blood Coagulation

VIII. Overview

References

Appendix: Amino Acid Sequences of Plasma Proteins

I. Introductory Remarks

II. Amino Acid Sequences

Index