The Pancreatic Beta Cell, Volume 95

1st Edition

Hardcover ISBN: 9780128001745
eBook ISBN: 9780128004401
Imprint: Academic Press
Published Date: 28th February 2014
Page Count: 520
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Table of Contents

Former Editors
Chapter One: Metabolic Regulation of Insulin Secretion

1 Introduction

2 Glucose Metabolism and Insulin Secretion

3 Fatty Acid Metabolism and Insulin Secretion

4 Amino Acid Metabolism and Insulin Secretion

5 Association of Nutrient Metabolism with Pancreatic β-Cell Dysfunction

6 Conclusions

Chapter Two: Proinsulin Entry and Transit Through the Endoplasmic Reticulum in Pancreatic Beta Cells

1 Overview of Insulin Biosynthesis in Pancreatic Beta Cells

2 Proinsulin Entry into the ER

3 Proinsulin Transit Through the ER

4 Conclusion and Perspective


Chapter Three: Metabolism–Secretion Coupling and Mitochondrial Calcium Activities in Clonal Pancreatic β-Cells

1 Introduction

2 The Importance of Mitochondria to β-Cell Function

3 Oxidative Metabolism of β-Cells

4 Mitochondrial Ca2 + and Energy Metabolism

5 Ca2 + Handling in β-Cells


Chapter Four: Metabolic Syndrome and Ionic Channels in Pancreatic Beta Cells

1 Introduction

2 A Rapid Fly on Metabolic Syndrome

3 Physiology of Pancreatic Islets in Glucose Homeostasis

4 Physiology and Pathophysiology of Ionic Channels

5 Concluding Remarks

Chapter Five: The Beta Cell Immunopeptidome

1 Introduction

2 Autoantigens in T1D

3 Antigen Processing

4 Identifying T Cell Epitopes in T1D

5 Peptide-Based Intervention and the Role of Small Molecules

6 Advances in Mass Spectrometry for the Identification of PTMs

7 Conclusions

Chapter Six: Autophagy and Pancreatic β-Cells

1 Introduction

2 Autophagy

3 Autophagy and Pancreatic β-Cell Homeostasis

4 Adaptive Autophagy in Pancreatic β-Cell

5 Autopha


First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones.  A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.

This volume focuses on the pancreatic beta cell.

Key Features

  • Expertise of the contributors
  • Coverage of a vast array of subjects
  • In depth current information at the molecular to the clinical levels
  • Three-dimensional structures in color
  • Elaborate signaling pathways


Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested.


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© Academic Press 2014
Academic Press
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