Description

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones.  A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.

This volume focuses on the pancreatic beta cell.

Key Features

  • Expertise of the contributors
  • Coverage of a vast array of subjects
  • In depth current information at the molecular to the clinical levels
  • Three-dimensional structures in color
  • Elaborate signaling pathways

Readership

Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested.

Table of Contents

Former Editors
Contributors
Preface
Chapter One: Metabolic Regulation of Insulin Secretion
Abstract

1 Introduction

2 Glucose Metabolism and Insulin Secretion

3 Fatty Acid Metabolism and Insulin Secretion

4 Amino Acid Metabolism and Insulin Secretion

5 Association of Nutrient Metabolism with Pancreatic β-Cell Dysfunction

6 Conclusions

Chapter Two: Proinsulin Entry and Transit Through the Endoplasmic Reticulum in Pancreatic Beta Cells
Abstract

1 Overview of Insulin Biosynthesis in Pancreatic Beta Cells

2 Proinsulin Entry into the ER

3 Proinsulin Transit Through the ER

4 Conclusion and Perspective

Acknowledgments

Chapter Three: Metabolism–Secretion Coupling and Mitochondrial Calcium Activities in Clonal Pancreatic β-Cells
Abstract

1 Introduction

2 The Importance of Mitochondria to β-Cell Function

3 Oxidative Metabolism of β-Cells

4 Mitochondrial Ca2 + and Energy Metabolism

5 Ca2 + Handling in β-Cells

Acknowledgments

Chapter Four: Metabolic Syndrome and Ionic Channels in Pancreatic Beta Cells
Abstract

1 Introduction

2 A Rapid Fly on Metabolic Syndrome

3 Physiology of Pancreatic Islets in Glucose Homeostasis

4 Physiology and Pathophysiology of Ionic Channels

5 Concluding Remarks

Chapter Five: The Beta Cell Immunopeptidome
Abstract

1 Introduction

2 Autoantigens in T1D

3 Antigen Processing

4 Identifying T Cell Epitopes in T1D

5 Peptide-Based Intervention and the Role of Small Molecules

6 Advances in Mass Spectrometry for the Identification of PTMs

7 Conclusions

Chapter Six: Autophagy and Pancreatic β-Cells
Abstract

1 Introduction

2 Autophagy

3 Autophagy and Pancreatic β-Cell Homeostasis

4 Adaptive Autophagy in Pancreatic β-Cell

5 Autopha

Details

No. of pages:
520
Language:
English
Copyright:
© 2014
Published:
Imprint:
Academic Press
Print ISBN:
9780128001745
Electronic ISBN:
9780128004401