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The Opioid System as the Interface between the Brain’s Cognitive and Motivational Systems - 1st Edition - ISBN: 9780444641670, 9780444641687

The Opioid System as the Interface between the Brain’s Cognitive and Motivational Systems, Volume 239

1st Edition

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Serial Volume Editor: Shane O'Mara
Hardcover ISBN: 9780444641670
eBook ISBN: 9780444641687
Imprint: Academic Press
Published Date: 12th October 2018
Page Count: 266
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Table of Contents

1. Potential roles for opioid receptors in motivation and major depressive disorder
Charlotte K. Callaghan, Jennifer Rouine and Shane M. O'Mara
2. Opioid modulation of depression: A focus on imaging studies
Jennifer Rouine, Charlotte K. Callaghan and Shane M. O’Mara
3. Modulation of the central opioid system as an antidepressant target in rodent models
Kelly L. McHugh and John P. Kelly
4. Stress-induced modulation of pain: Role of the endogenous opioid system
Mehnaz Ferdousi and David P. Finn
5. Opioid modulation of cognitive impairment in depression
Moriah L. Jacobson, Hildegard A. Wulf, Caroline A. Browne and Irwin Lucki
6. Frontal cortex dysfunction as a target for remediation in opiate use disorder: Role in cognitive dysfunction and disordered reward systems
Dominic Roberts, Andrew Wolfarth, Connie Sanchez and Alan L. Pehrson


The Opioid System as the Brain’s Interface between Cognition and Motivation, Volume 239, focuses on the opioid system as the interface between the brain’s cognitive and motivational systems. As the opioid system is widely distributed through the brain, particularly in areas implicated in cognition (hippocampus, prefrontal cortex, claustrum, thalamus) and motivation (hypothalamus, amygdala, pontine nuclei, periaqueductal gray and medulla), this book provides chapters that address ongoing research on topics such as the Brain’s cognitive system, the Brain’s motivational system, Antidepressant prescription patterns, Antidepressant-like effects of opioid receptor modulators, the Behavioral effects of antidepressant and anxiolytic drugs, and more.

Key Features

  • Contains contributions from both academia and industry to maximize the cross-fertilization of differing perspectives on opioid system function in health and disease
  • Studies the opioid system as the interface between the brain’s cognitive and motivational systems


Industry groups interested in drug discovery to academic neuroscience groups interested in fundamental mechanisms of opioid system function in the brain


No. of pages:
© Academic Press 2018
12th October 2018
Academic Press
Hardcover ISBN:
eBook ISBN:

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About the Serial Volume Editor

Shane O'Mara

Shane O’Mara is Professor of Experimental Brain Research (Personal Chair) at Trinity College, Dublin - the University of Dublin. He is a Principal Investigator in, formerly Director of, the Trinity College Institute of Neuroscience, one of Europe’s leading research centres for neuroscience. He is also a Wellcome Trust Senior Investigator and a Science Foundation Ireland Principal Investigator. His research explores the brain systems supporting learning, memory, and cognition, and also the brain systems affected by stress and depression. He also explores the intersection of psychology and neuroscience with public policy, evidence-based policy-making and related areas. He has published about 130 peer-reviewed papers on these topics. His books include 'Why Torture Doesn’t Work: The Neuroscience of Interrogation' (Harvard University Press; 2015); 'A Brain for Business – A Brain for Life' (Palgrave Macmillan) and 'In Praise of Walking' (Bodley Head, 2019). He is a graduate of the National University of Ireland - Galway (BA, MA), and of the University of Oxford (DPhil). He is an elected Fellow of the Association for Psychological Science (USA), and an elected Member of the Royal Irish Academy.

Affiliations and Expertise

Professor, Trinity College, Dublin, Ireland