The Neuroscience of Traumatic Brain Injury

The Neuroscience of Traumatic Brain Injury

1st Edition - July 29, 2022

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  • Editors: Rajkumar Rajendram, Victor Preedy, Colin Martin
  • Hardcover ISBN: 9780323991971

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Diagnosis and Treatment of Traumatic Brain Injury will improve readers’ understanding of the complexities of diagnosis and management of traumatic brain injuries. Featuring chapters on drug delivery, different treatments, and rehabilitation, this volume discusses in detail the impact early diagnosis and effective management has on the long-term prognosis of these injuries and the lives of those affected. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries. Traumatic brain injury has complex etiology and may arise as a consequence of physical abuse, violence, war, vehicle collisions, working in the construction industry, and sports. Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury will improve readers’ understanding of the detailed processes arising from  traumatic brain injury. Featuring chapters on neuroinflammation, metabolism, and psychology, this volume discusses the impact of these injuries on neurological and body systems to better understand underlying pathways. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand traumatic brain injury.

Key Features

Diagnosis and Treatment of Traumatic Brain Injury:

  • Covers both the diagnosis and treatment of traumatic brain cord injury
  • Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding
  • Features chapters on epidemiology and pain
  • Includes MRI usage, biomarkers, and stem cell and gene therapy for management of spinal cord injury
  • Discusses pain reduction, drug delivery, and rehabilitation

Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury:

  • Summarizes the neuroscience of traumatic brain injury, including cellular and molecular biology
  • Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding
  • Features chapters on signaling and hormonal events
  • Includes plasticity and gene expression
  • Examines health and stress behaviors after traumatic brain injury


Designed for research and teaching purposes, it is suitable for neuroscientists, neurologists, clinicians, health scientists, public health workers, doctors, and research scientists. It is valuable as a personal reference book and also for academic libraries that covers the domains of neurology and health sciences. It is also suitable for undergraduates, postgraduate, lecturers and academic professors

Table of Contents

  • Diagnosis and Treatment of Traumatic Brain Injury:
    I. Setting The Scene and Introductory Chapters
    1. Traumatic brain injury, and in-hospital mortality: perfusion CT and beyond
    Sudharsana Rao Ande and Jai Jai Shiva Shankar
    2. Predictors of outcome in moderate and severe traumatic brain injury
    Rosalia Zangari, Paolo Gritti and F. Biroli
    3. 30 years post-injury: .Impact of traumatic brain injury on later Alzheimer's disease
    Takashi Hiraoka and Kozo Hanayama
    4. Drug Interventions and Stem Cells in Traumatic Brain Injury: Translation from Experimental Model to Bedside
    Firas H. Kobaissy and Maha Tabet
    5. Management of Traumatic Brain Injury from The Aspect of Emergency Department and Case Studies
    Bedriye Müge M. Sönmez
    6. Neuropsychiatric disorders after severe traumatic brain injury: an overview
    Dolores Villalobos, U. Bivona and Maria Paola Ciurli

    II. Clinical Features of Traumatic Brain Injury
    7. Cerebral hemorrhages in traumatic brain injury
    Andrei Irimia
    8. Linking fibrinogen, coagulopathy prophylaxis and traumatic brain injury
    Ryuta Nakae and Shoji Yokobori
    9. Linking traumatc brain injury and osocomial infections
    Antoine Roquilly
    10. Late-life neurodegenerative disorders due to traumatic brain injury: Epidemiology, clinical symptoms and in vivo quantification of neuropathology
    Keisuke Takahata, Kenji Tagai, Makoto Higuchi and Masaru Mimura
    11. Evaluating the integrity of white matter after traumatic brain injury and the clinical utility of diffusion tensor imaging
    Eunkyung Kim, Min-Gu Kang and Byung-Mo Oh
    12. Cerebral activation of attention and working memory in traumatic brain injury
    Athena Stein, Kartik K. Iyer and Karen Barlow
    13. Traumatic brain injury: Linking intracranial pressure, arterial pressure and the pressure reactivity index
    Alwyn Titus Gomez, Carleen Batson, Logan Froese and Frederick A. Zeiler
    14. Cerebral perfusion pressure parameters and traumatic brain injury
    Alwyn Titus Gomez, Carleen Batson, Logan Froese and Frederick A. Zeiler
    15. Brain swelling in traumatic brain injury
    Silvia De Rosa
    16. Severe traumatic brain Injury and post-coma syndrome
    Rita Formisano

    III. Diagnosis and Evaluation
    17. Features of the World Health Organization Disability Assessment Schedule 2.0 and its applications for traumatic brain injury assessment
    T.-H. Liou
    18. Biomarkers in pediatric traumatic injury: the brain and beyond
    George Alexiou, Dimitrios Metaxas, Olga Ygropoulou, Dimitrios Rizos and Spyridon Voulgaris
    19. Brain injury biomarkers: Proteins and autoantibodies Interplay
    Firas H. Kobaissy and Samar Abdelhady
    20. Chitinase-3-Like Protein 1: features and applications as a biomarker in traumatic brain injury
    C. S. Carabias and A. Lagares
    21. Micro-RNA: features and bio markers in traumatic brain injury: a new narrative
    Steven Hicks
    22. Pediatric minor head injury imaging
    George Alexiou, Spyridon Voulgaris and Anastasios Nasios
    23. Traumatic brain injury: Use of transcranial doppler and injury severity
    Alexey O. Trofimov
    24. Computed tomography assessment of brain swelling
    Matheus Fernandes de Oliveira
    25. Machine learning and prediction of traumatic brain injury mortality
    W. S. Paiva and João Gustavo Rocha Peixoto dos Santos Sr.
    26. Pituitary dysfunction after traumatic brain injury: a focus on screening, diagnosis and treatment
    Fahrettin Kelestimur, Zuleyha Karaca and Aysa Hacioglu

    IV. Treatments: Experimental and Clinical
    27. European aspects of Guidelines used in traumatic brain injury
    Alvaro Cordoba
    28. Anesthesia in traumatic brain injury
    Girija Prasad Rath
    29. Treatment of raised intracranial pressure in traumatic head injury
    Alvaro Cordoba
    30. Seizures after traumatic brain injury and their treatment
    L.F.F. Royes
    31. Neurosurgical treatment of critical brain damage
    Alexey O. Trofimov
    32. Hypertonic saline usage in traumatic brain Injury: a focus on pediatrics
    Andrew G. Wu, Tina Slusher and Andrew Kiragu
    33. Treatment of vascular lesions in traumatic head injury
    Alvaro Cordoba
    34. Airway Pressure Release Ventilation (APRV) in traumatic brain injury
    E. Eriksson and Chris Thomas
    35. Linking death, the paranasal sinuses and traumatic head trauma Treatments: Experimental and Clinical
    A. Kanat
    36. Oral cannabidiol in modulation of mild traumatic brain injury
    Sabatino Maione
    37. Valproic acid: features and effects in traumatic brain injury: a new narrative
    Michael T. Kemp
    38. Dietary supplementation for traumatic brain injury
    Mohan Raja, Agilandeswari Devarajan and Vipin V. Dhote

    V. Rehabilitation in traumatic brain injury
    39. Virtual reality and cognitive rehabilitation after traumatic brain injury
    Rocco S. Calabrò and Maria Grazia Maggio
    40. How the elderly and young compare in response to traumatic brain injury rehabilitation
    Sung-Bom Pyun and Doo-Young Kim
    41. Rehabilitation of social cognition in traumatic brain injury
    Philippe Allain
    42. Psycho-educational Intevention on caregivers within the rehabilitation process: from the post-acute to the homecoming phases
    U. Bivona

    VI. Resources
    43. Resources
    Rajkumar Rajendram

    Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury:
    I. Setting The Scene and Introductory Chapters
    1. Fall-related traumatic brain injuries: The role of the neck
    Jacob Sosnoff and Tobia Zanotto
    2. The implications of sex and gender in traumatic brain injury
    Tatyana Mollayeva
    3. Concussion and sports injuries the role of repetitive head injury exposure
    Brian D. Stemper
    4. Traumatic brain injury and molecular biology: a new narrative
    Asma Akbar Ladak, Sarosh Irfan Madhani, Fatima Gauhar, Kiran Aftab, Fatima Mubarak and Syed Ather Enam
    5. Features of Decompressive Craniectomy in Traumatic Brain Injury: History, Effects, Management and New Trends
    Zefferino Rossini
    6. Management of Traumatic Brain Injury in Accordance With Contemporary Guidelines: Treatment, Monitorization and Thresholds
    Gregory W.J. Hawryluk and Buse Sarigul

    II. Cellular and Molecular Aspects of Traumatic Brain Injury
    7. Neuroinflammatory responses in traumatic brain injury
    J Narayanan, T. Tamilanban, V. Chitra and M.K Kathiravan
    8. Seizures in traumatic brain injury: a focus on cellular aspects
    Thara Tunthanathip
    9. Linking traumatic brain injury, neural stem and progenitor cells
    Li Cai
    10. The microglia in traumatic brain injury
    Ramesh Raghupathi, Dana Lengel and JIMMY HUH
    11. Dendritic spine plasticity and traumatic brain injury
    Ye Xiong, Asim Mahmood and Michael Chopp
    12. Immune response and traumatic brain injury
    Sandy Shultz and Mujun Sun
    13. The adaptive immune system in traumatic brain injury: a focus on T and B lymphocytes
    Maria Daglas, Robert Medcalf and Maithili Sashindranath
    14. Regulatory T cells and traumatic brain injury
    Michael K.E. Schäfer
    15. The role of prokineticin 2 in traumatic brain injury
    Marimelia A. Porcionatto
    16. Na+/K+- ATPase activity and traumatic brain injury
    L.F.F. Royes
    17. Pyruvate dehydrogenase complex enzymes, metabolic enzymes and energy derangement in traumatic brain injury
    Giacomo Lazzarino, Patrick O’Halloran, Valentina Di Pietro, Renata Mangione, Barbara Tavazzi, Angela Maria Amorini, giuseppe lazzarino and Stefano Signoretti
    18. Angiopoietin-1/Tie-2 and traumatic brain injury
    Yutaka Koyama and Shotaro Michinaga
    19. Brain microdialysis and applications to drug therapy in severe traumatic brain injury
    N. Ketharanathan, U. Rohlwink, A. Figaji, Enno Wildschut, D. Tibboel and Elizabeth Cunera maria de Lange
    20. Comparing radiation and traumatic brain injuries: new narrative
    Steve Kornguth
    21. Electrolytes and traumatic brain injury: a focus on sodium
    Yvonne Lui and Hemal Grover
    22. WNT genes and their role in traumatic brain injury
    Linyi Chen, Min-Zong Liang and Chu-Yuan Chang

    III. Physiological and Metabolic Effects
    23. Circuit Reorganization After Diffuse Axonal Injury: Utility of the Whisker Barrel Circuit
    Theresa Currier Thomas and Gokul Krishna
    24. Neuroendocrine Abnormalities Following Traumatic Brain Injury
    Jehane Dagher and Benjamin Green
    25. Thyroid hormone actions in the setting of traumatic brain injury
    Adomas Bunevicius
    26. Testosterone: features and role in treating traumatic brain injury
    L. Portela
    27. The rate of empty sella (ES) in traumatic brain injury: links with endocrine profiles
    Fausto Fama, Alessandro Sindoni, Ulla Feldt-Rasmussen, Salvatore Benvenga and Marianne Klose
    28. Traumatic brain injury. Interrelationship with sleep
    Rachel Rowe
    29. Pubety and traumatic brain injury
    Rachel Rowe
    30. Role of endocannabinoids in the escalation of alcohol use following traumatic brain injury
    Patricia E. Molina, Zachary Stielper, Scott Edwards and Nicholas Gilpin
    31. Imaging connectivity and functional brain networks in mild traumatic brain injury
    Maria M. D'Souza, Mukesh Kumar, Jeanne D'Souza, Prabhjot Kaur and Pawan Kumar
    32. Multi-shell diffusion MR imaging and brain microstructure after mild traumatic brain injury: A focus on working memory
    Sohae Chung, Els Fieremans, Joseph Rath and Yvonne Lui
    33. Monitoring real-time changes in physiology: impact of pediatric traumatic brain injury
    Brian Appavu
    34. Blood gasses, arterial and end-tidal carbon dioxide in traumatic brain injury
    Jen-Ting Yang, Chun-Yu Wu, and David R. Wright
    35. Disturbances of cerebral microcirculation in traumatic brain injury: the role of changes in microcirculatory biomarkers
    Alexey O. Trofimov

    IV. Behavioural and Psychological Effects
    36. Social cognition in traumatic brain injury
    Philippe Allain
    37. Physical exercise: effects on cognitive function after traumatic brain injury
    Margalida Coll, Laura Amorós-Aguilar, David Costa-Miserachs, Isabel Portell-Cortés and Meritxell Torras-Garcia
    38. Linking cognitive function, diffuse traumatic brain injury and dementia
    Lyndsey Collins-Praino
    39. Neuropsychological Functioning of Children and Youth after Traumatic Brain Injury
    Paula Karina Perez-Delgadillo, Daniela Ramos-Usuga, Nini Lucia Muñoz-Perez and Juan Arango Arango-Lasprilla
    40. Behavioral effects of traumatic brain injury: use of guanosine
    Felix Alexandre Antunes Soares and Fernando Dobrachinski
    41. Recognizing emotions and effects of traumatic brain injury
    Alessia Celeghin, Ylenia Camassa Nahi, Blanca Tasso and Olga Dal Monte
    42. Cognitive Communication Connections and Higher-Level Language with Traumatic Brain Injured Population
    J. Koebli
    43. Self-awareness after severe traumatic brain injury: from impairment of Self-awareness to psychological adjustment
    U. Bivona, Susanna Lucatello and Alberto Costa
    44. Disentangling antecedents from consequences of traumatic brain injury: The need for prospective longitudinal studies
    Sheilagh Hodgins and G. Guberman
    45. Linking sleeping patterns and quality of life in childhood traumatic brain injury
    Edith Botchway

Product details

  • No. of pages: 1168
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: July 29, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780323991971

About the Editors

Rajkumar Rajendram

Dr. Rajendram is a clinician scientist whose focus is on perioperative medicine, anesthesia, and intensive care. He graduated in 2001 with a distinction from Guy’s, King’s, and St. Thomas Medical School in London, and began his postgraduate medical training in general medicine and intensive care in Oxford. Dr. Rajendram returned to Oxford as a consultant in general medicine at the John Radcliffe Hospital, Oxford, before moving to the Royal Free London Hospitals as a consultant in intensive care, anesthesia, and perioperative medicine. He is currently a consultant in internal and perioperative medicine at King Abdulaziz Medical City, Riyadh, Saudi Arabia. As a visiting lecturer in the Division of Diabetes and Nutritional Sciences, King’s College London, he has published over 100 textbook chapters, review articles, peer-reviewed papers, and abstracts.

Affiliations and Expertise

Visiting Lecturer, Division of Diabetes and Nutritional Sciences, King’s College London, UK

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Mental Health, Bickinghamshire New University, High Wycombe, Buckinghamshire, UK

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