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The Neuroscience of Dementia - 1st Edition - ISBN: 9780128160435

The Neuroscience of Dementia

1st Edition

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Editors: Colin R. Martin Victor Preedy
Hardcover ISBN: 9780128160435
Imprint: Academic Press
Published Date: 15th August 2020
Page Count: 1920
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Description

The Neuroscience of Dementia brings together different fields of dementia research into a single book, covering a wide range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. This foundational, comprehensive book compiles the latest understanding on all forms of dementia and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.

Key Features

  • Offers comprehensive coverage of a broad range of topics related to dementia
  • Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
  • Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations
  • Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations
  • Serves as a "one-stop" source for everything you need to know about dementia

Readership

Neuroscientists/neurologists, psychologists, health scientists, public health workers, research scientists, pharmacologists, and physicians. Graduate/postgraduate students, lecturers, and professors

Table of Contents

DIAGNOSIS AND MANAGEMENT IN DEMENTIA

I. Dementia: Introductory Chapters and Setting the Scene
1. Mixed dementia: an overview
Jaqcues J. De Reuck
2. Vascular dementia: an overview
Virginia Cipollini
3. Small vessel disease and dementia
Francesco Arba
4. Linking Amyotrophic lateral sclerosis (ALS) and Frontotemporal dementia
Philippe Couratier
5. Mortality in dementia: linking in delirium
Thiago Silva
6. Midlife diabetes and the risk of dementia- understanding the link
Sean Kennelly and Adam H. Dyer
7. Gait and Alzheimer's disease /Gait and dementia
Michele Linda Callisaya
8. Hypertension and dementia
Rebecca F. Gottesman
9. Genetics of dementia: focus on Alzheimer’s disease
Francesca Fernandez
10. Clinical and pathological phenotypes in autosomal dominant frontotemporal dementia
Innocenzo Rainero
11. Risk factors in dementia: genetic and nongenetic
Evangelos Evangelou
12. Lipidomics and biomarker in Alzheimer’s disease
Perminder S. Sachdev and UNSW
13. The 5xFAD mouse model of Alzheimer’s disease
Sylvie Claeysen

II. Biomarkers, Psychometric Instruments And Diagnosis
14. Use of cerebrospinal fluid in diagnosis of dementia
Angelo Nuti
15. Salivary biomarkers in Alzheimer’s disease
Francesca Fernandez
16. Diacylglycerols as biomarkers in dementia
Paul Wood
17. Butyrylcholinesterase (BChE) as a biomarker in Alzheimer’s disease
Sultan Darvesh
18. Blood brain-derived neurotrophic factor as a biomarker of Alzheimers disease
Marta Balietti
19. Methods of amyloid PET Imaging and its applications to Alzheimer’s disease spectrum
Shizuo Hatashita Sr.
20. Applications of diffusion-weighted imaging (DWI) Tractography and Alzheimer’s disease
Nicola Amoroso
21. Transcranial Magnetic stimulation and diagnostic applications to dementias
Matthew Kiernan and Thanuja Dharmasada
22. Retinal imaging and dementia as a diagnostic tool
Carol Y. Cheung
23. The prediction of Alzheimer’s disease
Athanasios Alexou
24. Addenbrooke's Cognitive Examination
Jordi A. Matias-Guiu
25. The Montreal Cognitive Assessment (MoCA) and applications to dementia
Andrea Bosco
26. ALBA Screening Instrument (ASI) and applications to dementia
Angel Golimstok
27. The Quick Mild Cognitive Impairment (Qmci) screen and applications to dementia
Roger Clarnette
28. Assessment of activities of daily living (ADL) applied to dementia
Patricia De Vriendt

III. Pharmacological Treatments For Dementia
29. Cholinesterase inhibitors in dementias: an overview
Patrizia Mecocci
30. Choline-containing phospholipids and treatment of adult-onset dementia disorders
Francesco Amenta
31. Donepezil usage: a focused review
Francesco Amenta
32. Memantine: a focused review
Sergio del Rio Sancho
33. The benefits of calcium channel blockers for the therapy of dementia
L. Bergantin
34. Pitfalls for pharmacotherapeutic trials in dementia
T. Mueller
35. All-trans retinoic acid in Alzheimer’s disease
Siamak Beheshti
36. Dementias and usage of NMDA receptor antagonists
Brianna E. Glynn-Servedio
37. Dementia and bladder dysfunction: a focus on treatments with anticholinergics 
Ryuji Sakakibara
38. Linking astrocytes' exosomes to Alzheimer's pathogenesis and therapy
Anna Chiarini
39. Changing the fate: therapeutic mechanisms focus on the switch of beta-amyloid precursor protein (APP)
processing
Kristina Endres
40. Acetylcholinesterase inhibitory agents in plants and application to dementia: Alzheimers Disease
Willian Orlando Castillo-Ordonez
41. Removal of blood amyloid as a safety strategy
Nobuya Kitaguchi

IV. Non-Pharmacological Treatments and Procedures
42. Caring for people with Dementia in the Acute Hospital
R. Briggs and Sean Kennelly
43. Environmental enrichment in dementia
Kimberley Stuart
44. Music therapy in dementia
Alfredo Raglio and Lapo Attardo
45. Aromatherapy in dementia
G. Bagetta and Damiana Scuteri
46. Dancing in dementia
Lee-Fay Low and Kathryn Dovey
47. Hypoxic-hyperoxic training and dementia
Martin Burtscher
48. Linking amyloid and depression in dementia: effects of treatments by non-drug means
Akihiko Nunomura
49. Regional dementia care networks
Franziska laporte Uribe
50. Cognitive behavioural therapy (CBT) use in Alzheimer’s disease
Alicia Ann Walf
51. Maximizing cognition in Mild Cognitive Impairment and early-stage dementia
Bridget Regan
52. Exercise, cognitive creativity, and dementia
Paul D. Loprinzi
53. Linking care staff, person-focused communications and dementias
Marie Y. Savundranayagam

GENETICS, NEUROLOGY, BEHAVIOR, AND DIET IN DEMENTIA

I. Genetics, Molecular and Cellular Biology
1. The genetics of Alzheimer’s disease: a focus on the neuron navigator 2 gene
Kesheng Wang and Chun Xu
2. Interlinking polymorphisms, estrogens and Alzheimer’s disease
Y. Q. Song
3. Linking EEGs, Alzheimer’s disease and the Phosphatidylinositol binding clathrin assembly protein (PICALM) gene
Natalya Ponomareva
4. CD36 gene polymorphism and Alzheimer’s disease
O. Sery
5. Genetic contributions to sporadic frontotemporal dementia
Jennifer S. Yokoyama and Jessie S. Carr
6. Dementia and CYP2D6 polymorphisms
P. Caramelli
7. A1 purinergic receptor gene expression in dementia
Guadalupe Maria Garcia-Alcocer
8. Molecular aspects of metallothionein-1 in dememtias
Juan Hidalgo
9. MicroRNAs in Alzheimer's disease
Urszula Wojda
10. Oxidative stress and neurons in dementia
Elena Miranda
11. Toward an integrative understanding of the neuroinflammatory molecular milieu in Alzheimer's disease neurodegeneration
Nibaldo C. Inestrosa and Juan Zolezzi
12. Wnt Signalling and dementia
A.Angeles Martin-Requero Sr.
13. Linking PKC, PKClambda/I and Alzheimer’s disease
Robert V. Farese
14. Linking histone deacetylases, phosphodiesterase 5 and novel treatments Alzheimer’s disease
Ana Garcia-Osta
15. Linking Nrf2 and Alzheimers disease
Joshua Park
16. Role of alpha- and beta-secretase in Alzheimer’s disease
Kristina Endres
17. Methylation analysis of DNA in Alzheimer’s disease
Fabio Coppedè
18. The signalosome malfunctions in age-associated neuropathologies
Raquel Marin
19. ILEI/FAM3C in Alzheimer’s disease
Masaki Nishimura
20. Amylin and Alzheimer’s disease
Jack H. Jhamandas
21. Mammalian target of rapamycin (mTOR) complexes: Regulation and Alzheimer's disease
Henry Querfurth and Han Kyu Lee
22. Mammalian target of rapamycin (mTOR) complexes: Protein synthesis and autophagy, Parkinsons Disease, Amyotrophic Lateral Sclerosis and frontotemporal dementia
Henry Querfurth and Han Kyu Lee
23. Linking CD200 in brains and dementia: molecular aspects of neuroinflammation
D. Walker

II. Neurological, Physiological and Imaging
24. Hippocampal atrophy and dementia
Hiroshi Yao
25. Inflammation and insulin resistance in AD: partners in crime
D. Frenkel
26. Neuronal susceptibility to hypoxia in Alzheimer disease
Laura Calza
27. Neuropeptides and Neurolipids: what they are and how they relate to Alzheimers disease
Rafael Rodriguez
28. Brain receptors in Alzheimer’s disease
Rafael Rodriguez
29. Abeta42-alpha7-like nicotinic acetylcholine receptors and Alzheimer’s disease
Hoau-Yan Wang
30. Synaptosomal bioenergetics in Alzheimer’s disease
Laura Morelli
31. Limitations of amyloid-PET imaging
David Weidman
32. Linking Gradient Echo Plural Contrast Imaging (GEPCI) Metrics of Tissue Microstructure with Alzheimer
Dmitry A. Yablonskiy
33. Hypertensive disorders in pregnancy and later dementia
Ellika Andolf
34. Sleep architecture and the development of clinical dementia
Matthew Paul Pase

III. Behaviour and Psychopathology
35. An overview of behavioural and psychiatric symptoms of dementia
Dorothy M. Grillo
36. Delirium superimposed on dementia: from diagnosis to treatment
Alessandro Morandi
37. Self-Consciousness Deficits in dementia
E. Arroyo-Anllo
38. Attention impairements, novel images and Alzheimer’s disease
Krista Lanctot
39. Frontal Lobe Syndrome and Dementias
Petronilla Battista
40. The stigma of dementia
Albert Aboseif and Benjamin K.P. Woo
41. Delusions in dementias
Francesco Panza
42. Linking motor speech function and dementia
Adam P. Vogel and Matthew Poole
43. Spatial Navigation and Alzheimer’s disease
Benjamin Clark
44. Violence and dementia
G. Cipriani and Sabrina Danti
45. Caregiver depression in dementia
Sheung Tak Cheng

IV. Diet, Nutrition and Environment
46. Nutritional status in dementia
Kyung Ja Chang
47. Selenium and Alzheimer’s disease
Bárbara R. Cardoso
48. Linking adiponectin and obesity in dementia
M. Bednarska-Makaruk
49. The gut microbiome in Alzheimer's Disease
Kristina Endres
50. (-)-epigallocatechin-3-gallate (EGCG) and Alzheimer disease
Rafael de la Torre and Laura Xicota
51. Cadmium and Alzheimer’s disease
Sung Kyun Park

V. Models And Modelling In Dementia
52. Alzheimer's model 5xFAD mice as a model and applications to dementia
Yasuhisa Ano
53. Use of 192 IgG-saporin as a model of dementia and its application
Jin Woo Chang and Yong-sook Park
54. Abeta1-42 oligomer animal model of dementia
Josiane Budni
Resources
Rajkumar Rajendram

Details

No. of pages:
1920
Language:
English
Copyright:
© Academic Press 2020
Published:
15th August 2020
Imprint:
Academic Press
Hardcover ISBN:
9780128160435

About the Editors

Colin R. Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Perinatal Mental Health, Institute of Clinical and Applied Health Research (ICAHR), University of Hull, UK

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a staff member of the Faculty of Life Sciences and Medicine within King's College London. He is also a member of the Division of Diabetes and Nutritional Sciences (research) and the Department of Nutrition and Dietetics (teaching). Professor Preedy is also Director of the Genomics Centre of King's College London. Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctorate (DSc), for his outstanding contribution to protein metabolism in health and disease. Professor Preedy was elected as a Fellow to the Institute of Biology in 1995 and to the Royal College of Pathologists in 2000. Since then he has been elected as a Fellow to the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry. Professor Preedy has carried out research when attached to Imperial College London, The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. Prof Preedy is a leading expert on the science of health and has a long standing interest in neurological disease and tissue pathology. He has lectured nationally and internationally. To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

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