The Neuroscience of Aging

The Neuroscience of Aging

1st Edition - June 25, 2021

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  • Editors: Colin Martin, Victor Preedy, Rajkumar Rajendram
  • Paperback ISBN: 9780128183694

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Description

Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain including Alzheimer’s, stroke, and multiple sclerosis. Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. It also examines the use of animal modelling of aging and neurological disease.

Key Features

Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging:

  • Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of aging
  • Features sections on diagnosis and biomarkers of neurological aging, Alzheimer’s, and stroke
  • Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
  • Focuses on neurological diseases and conditions linked to aging, environmental factors, and clinical recommendations
  • Includes more than 500 illustrations and tables

Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet:

  • Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of aging
  • Features sections on the genetics influencing aging and diseases of aging
  • Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
  • Focuses on neurological diseases and conditions linked to aging, environmental factors, and clinical recommendations
  • Includes more than 500 illustrations and tables

Readership

Neuroscientists, geriatricians, neurobiologists, experimental biologists, clinicians, graduate students, and post-doctoral fellows

Table of Contents

  • Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging

    I. Introductory chapters: Setting the scene for the neuroscience of aging
    1. The concept of productive aging
    Premchand Dommaraju
    2. Quality of life in the over 80s
    Timo Strandberg
    3. Successful aging and diet
    D. Panagiotakos and Ekavi Georgousopoulou
    4. The impact of positive social relations on the quality of life of older people. An alternative to medicalization from an integral perspective
    L. Rondon Garcia
    5. The brain in life span: use of phase fMagnetic Resonance Imaging (MRI)
    Zikuan Chen
    6. Neuronal structure in aging: Cytoskeleton in health and disease
    Daniele Cartelli
    7. Sporadic Alzheimer’s Triad: Age, Sex, and ApoE
    L. Zhao
    8. How polymorphisms impact: BDNF polymorphism, inhibitory performance and the elderly
    Michel Francis Audiffren
    9. Menopause as an aging process and alcohol misuse
    Jelena Milic
    10. Brain banking and aging
    Glenda Halliday and Claire Elaine Shepherd

    II. Impairments and Diseases
    11. Dementia or no dementia in the very elderly. Why?
    Lewis H. Kuller
    12. Neuropsychology, Social Cognition and Loss of Insight in Frontotemporal Dementia
    Fiadhnait O'Keeffe
    13. Neuroinflammation in the elderly
    J. Malva
    14. Cortical microinfarcts and the aging brain
    E. Kovari
    15. Vascular brain injury and neurodegeneration in elderly racial and ethnic minority populations
    A. Suchy-Dicey
    16. Hearing loss amongst the elderly
    Gary Jek Chong Lee
    17. Aging Auditory Cortex: The Impact of Reduced Inhibition on Function
    Björn Herrmann
    18. Aging and vestibular disorders
    Augusto Pietro Casani
    19. Brain aging in HIV and antiretrovirals
    Jasmina Boban
    20. Antioxidants, Methylmercury, and Aging
    Andrew Shen and Christopher Newland
    21. Aging and the effects of ethanol on the brain: Comparing the effects of different aging
    Doug Matthews

    III. Biomarkers And Diagnosis
    22. Aging brain: Radiological biomarkers
    Banu Alicioglu Jr.
    23. Plasma ADAM10 as a biomarker of mental impairment in the elderly
    Mariana Luciano de Almeida
    24. Circulating microRNAs as biomarkers of healthy elderly
    Jonas Mengel-From Sr.
    25. DHEA as a biomarker of aging in humans and nonhuman primates: Synthesis, neuroprotection and cognitive
    function
    H. Urbanski
    26. Evaluation of subjective memory abilities in elderly people
    Luigi Trojano
    27. The Functional Activities Questionnaire: applications to aging
    Ondrej Bezdicek Sr.
    28. Autobiographical memory as a diagnostic tool in aging
    Juan C. Melendez
    29. Assessment tools for subjective memory abilities in elderly people
    Luigi Trojano
    30. Knowledge of Memory Aging
    Katie E. Cherry

    IV. Management and Treatments
    31. Pharmacological use of transient receptor potential (TRP) ion channel antagonists in neurological disease: effects on swallowing and implications for nutrition
    P. Clave and Noemí Tomsen
    32. Aripiprazole: features and use in the aged
    Unax Lertxundi
    33. Cognition-Enhancing Drugs and Applications to Aging
    Jelena Milic
    34. Creatine supplementation and impact on the aging brain
    B. Gualano
    35. Photobiomodulation as a brain-boosting strategy in aging
    Saeed Sadigh-Eteghad
    36. Innovation in deep brain stimulation in aging: a focus on Parkinson Disease
    Paolo Amami
    37. Exergames: what they are and how they can be used to improve cognition in aging
    Renato Sobral Monteiro-Junior, Ana Rodrigues, Laís Felício, Luiz Figueiredo and Túlio Rocha
    38. Linking cognitive decline and ballroom dance as a therapeutic intervention in the elderly
    Jacqueline C. Dominguez
    39. Active experiencing training in the elderly
    Maria Requena
    40. Psychiatric self-management, smartphone apps and older adults
    Karen Fortuna
    41. Psychosocial Interventions for Suicide Prevention in the Elderly: Advances and Future Directions
    D. Kiosses

    V. Models And Modelling
    42. D-galactose-induced aging and brain mitochondria
    Fereshteh Farajdokht
    43. Drosophila as a model organism in ageing research
    Maximo Ibo Galindo
    44. The Zebrafish (Danio rerio) and its uses for understanding the neuroscience of aging: applications and observation
    Michelle M. Adams
    45. Murine models of primary Tauopathy as a model of aging
    David Westaway
    46. Modelling nutrition and brain aging in rodents
    Devin Wahl
    47. Modelling primates and neurological aging: a focus on Alzheimer's disease
    Melissa K. Edler
    48. Linking aging and animal models to neurodegeneration: the Striatum, Substantia Nigra and Parkinson's Disease
    Rodrigo Portes Ureshino
    49. Behavioral evaluation of aging
    Ana Perez-Villalba

    VI. Resources
    50. Research and recommended resources in the neuroscience of aging
    Rajkumar Rajendram


    Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, And Diet

    I. Genetics, Molecular and Cellular Biology
    1. Genetics of frontotemporal dementia
    Ebru Erzurumluoglu Gokalp, Demet Adapinar and Sevilhan Artan
    2. Aging, brain-derived neurotrophic factor (BDNF) and its polymorphism
    Ting Shen
    3. Aging, demented patients, and polymorphisms in cytokine genes
    Karina Braga Borges
    4. RNA fragments and brain aging
    Andrey Grigoriev
    5. Centrosome functions and remodeling during neuronal development and centrosome abnormalities in neuronal disorders, disease, and in aging
    H. Schatten
    6. Brain aging and microarray analysis
    Michelino Di Rosa
    7. Human nuclear tau and aging
    Salvatore Saccone
    8. Lipoxidation: features, neurological tissues and aging
    Reinald Pamplona Sr.
    9. Aging and brain amino acids
    M. Furuse
    10. How 3’,5’-cyclic nucleotide phosphodiesterases change in the brain with normal aging and dementia
    Michy Kelly
    11. The prohibitin complex in aging and neurodegeneration
    Enrique Santamaría
    12. Synaptic ATPase and energy metabolism in the nervous system: roles and changes in the aging process
    Roberto Villa and Federica Ferrari

    II. Neurological and Imaging Features
    13. Microstructural Imaging of the Human Brain with Normal and "Abnormal" Aging using Diffusion Magnetic Resonance Imaging
    Yu-Chien Wu
    14. Imaging the brain and its vascular in aging: applications of optical coherence tomography angiography
    Ruikang Wang
    15. Potential involvement of perineuronal nets in brain aging: an anatomical point of view
    Shozo Jinno
    16. Grey-matter networks in aging
    Marisa Koini
    17. Brain synapse-related proteins what they do and how they change in aging
    Yoshimi Takai
    18. Macro- and chaperone-mediated autophagy in aging
    Ben Loos
    19. Neuronal L-type calcium channels in aging
    Tuck Wah Soong
    20. D-serine-regulated glutamatergic transmission and microglia: impact of aging
    Jaime L. Eugenin
    21. Voltage-gated potassium channels and the aging brain
    Federico Sesti
    22. Dendritic spine remodeling and aging
    Jeremy Herskowitz
    23. High-density lipoprotein-cholesterol and neuroaging: memory, gyrification of the insular and frontal opercular cortex
    Ryuta Kinno
    24. Astrocyte and microglial aging: morphology and modelling
    A. MacLean
    25. Neural scaffolding: features, profiles and the aging cerebellum
    Pavel Filip
    26. BACE1 RNAi, memory and aging
    P. Cardona-Gomez
    27. Aging, myelination and the optic nerve
    H. Attia and Ahmed Abdellatif
    28. Linking proteostasis, brain aging, and ischemia
    Wei Yang
    29. Luteinizing hormone and the aging nervous system
    G. Casadesus
    30. Insights into aging using transcranial magnetic stimulation
    D. Blumberger
    31. Alpha rhythms: What they are and how they alter with aging
    Maria Knyazeva
    32. Nicotine and its derivatives in healthy brain aging
    Saeed Sadigh-Eteghad

    III. Physiological Aspects
    33. Environmental enrichment and physiological aging
    Alla Salmina
    34. Treadmill exercise and neuroinflammation: links with aging
    Caroline Real
    35. Impact of aerobic exercise on brain structure in models of aging: hippocampus and beyond
    Lars S. Stiernman, Chelsea Stillman and Kirk Erickson
    36. The physiology of fitness and the brain in aging
    Monica Fabiani
    37. Aging, Babble Noise and the processing of speech perception
    A. N. Yusoff
    38. The blood-brain barrier in aging
    F. Erdo

    IV. Behavior And Psychopathological Aspects
    39. Linking aging, anticholinergic drug use, and cognitive impairment
    Virginia Boccardi
    40. Cognitive Frailty: Definition, components and impact on disability, and mortality
    Francesco Panza
    41. The physiology of the "Brain-muscle loop" in aging
    F. Lauretani
    42. Disentangling the effects of aging and ovarian hormone loss on sleep: Implications for health and disease
    Nicole Gervais
    43. Role of DNA methylation in aging-related cognitive functioning'
    Anna Starnawska
    44. Depression in the elderly and psychobiotics
    Elnaz Vaghef-Mehrabany

    V. Diet And Nutrition
    45. Aging, dietary patterns and cognition
    Angela Marie Abbatecola
    46. Geriatric nutritional risk index: Application, and limitations
    Elnaz Vaghef-Mehrabany
    47. Diet, inflammatory biomarkers, and brain aging
    Yian Gu
    48. DASH diet and brain aging
    Stephanie Ruth Rainey-Smith
    49. The ketogenic diet and healthy brain aging
    Georgia Anne Francis Rogerson
    50. Autophagy and aging: diet, exercise, and the link with the target of rapamycin complex 1 (TORC)
    Kurt Anthony Escobar
    51. Dietary Flavonoids and Brain Health in Ageing: food for Thought
    Justin S. Rhodes and Catarina Rendeiro
    52. Antioxidant effects of curcumin and neuroaging
    Shameemah Abrahams
    53. Lipoic acid and vitamin D3 and their use in preventing brain aging
    Francesca Uberti
    54. Aging and working memory: impact of the leucine metabolite beta hydroxy-beta-methyl butyrate
    Joshua M. Gulley and Roberto Galvez
    55. Hydration, the brain and aging
    Agata Białecka-Dębek

Product details

  • No. of pages: 1352
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: June 25, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780128183694

About the Editors

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Mental Health, Bickinghamshire New University, High Wycombe, Buckinghamshire, UK

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Rajkumar Rajendram

Dr. Rajendram is a clinician scientist whose focus is on perioperative medicine, anesthesia, and intensive care. He graduated in 2001 with a distinction from Guy’s, King’s, and St. Thomas Medical School in London, and began his postgraduate medical training in general medicine and intensive care in Oxford. Dr. Rajendram returned to Oxford as a consultant in general medicine at the John Radcliffe Hospital, Oxford, before moving to the Royal Free London Hospitals as a consultant in intensive care, anesthesia, and perioperative medicine. He is currently a consultant in internal and perioperative medicine at King Abdulaziz Medical City, Riyadh, Saudi Arabia. As a visiting lecturer in the Division of Diabetes and Nutritional Sciences, King’s College London, he has published over 100 textbook chapters, review articles, peer-reviewed papers, and abstracts.

Affiliations and Expertise

Visiting Lecturer, Division of Diabetes and Nutritional Sciences, King’s College London, UK

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