The Neuroscience of Aging

1st Edition - June 25, 2021
Editors: Colin R Martin, Victor R Preedy, Rajkumar Rajendram
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 1 8 3 6 9 - 4
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 8 3 7 0 - 0

Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurol… Read more

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Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain including Alzheimer’s, stroke, and multiple sclerosis.

Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. It also examines the use of animal modelling of aging and neurological disease.

Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging

I. Introductory chapters: Setting the scene for the neuroscience of aging 1. The concept of productive agingPremchand Dommaraju2. Quality of life in the over 80sTimo Strandberg3. Successful aging and dietD. Panagiotakos and Ekavi Georgousopoulou4. The impact of positive social relations on the quality of life of older people. An alternative to medicalization from an integral perspectiveL. Rondon Garcia5. The brain in life span: use of phase fMagnetic Resonance Imaging (MRI)Zikuan Chen6. Neuronal structure in aging: Cytoskeleton in health and diseaseDaniele Cartelli7. Sporadic Alzheimer’s Triad: Age, Sex, and ApoEL. Zhao8. How polymorphisms impact: BDNF polymorphism, inhibitory performance and the elderlyMichel Francis Audiffren9. Menopause as an aging process and alcohol misuseJelena Milic10. Brain banking and aging Glenda Halliday and Claire Elaine Shepherd

II. Impairments and Diseases11. Dementia or no dementia in the very elderly. Why?Lewis H. Kuller12. Neuropsychology, Social Cognition and Loss of Insight in Frontotemporal DementiaFiadhnait O'Keeffe13. Neuroinflammation in the elderlyJ. Malva14. Cortical microinfarcts and the aging brainE. Kovari15. Vascular brain injury and neurodegeneration in elderly racial and ethnic minority populationsA. Suchy-Dicey16. Hearing loss amongst the elderlyGary Jek Chong Lee17. Aging Auditory Cortex: The Impact of Reduced Inhibition on FunctionBjörn Herrmann18. Aging and vestibular disordersAugusto Pietro Casani19. Brain aging in HIV and antiretrovirals Jasmina Boban20. Antioxidants, Methylmercury, and AgingAndrew Shen and Christopher Newland21. Aging and the effects of ethanol on the brain: Comparing the effects of different agingDoug Matthews

III. Biomarkers And Diagnosis 22. Aging brain: Radiological biomarkersBanu Alicioglu Jr.23. Plasma ADAM10 as a biomarker of mental impairment in the elderlyMariana Luciano de Almeida24. Circulating microRNAs as biomarkers of healthy elderlyJonas Mengel-From Sr.25. DHEA as a biomarker of aging in humans and nonhuman primates: Synthesis, neuroprotection and cognitivefunctionH. Urbanski26. Evaluation of subjective memory abilities in elderly peopleLuigi Trojano27. The Functional Activities Questionnaire: applications to agingOndrej Bezdicek Sr.28. Autobiographical memory as a diagnostic tool in agingJuan C. Melendez29. Assessment tools for subjective memory abilities in elderly peopleLuigi Trojano30. Knowledge of Memory AgingKatie E. Cherry

IV. Management and Treatments 31. Pharmacological use of transient receptor potential (TRP) ion channel antagonists in neurological disease: effects on swallowing and implications for nutrition P. Clave and Noemí Tomsen32. Aripiprazole: features and use in the agedUnax Lertxundi33. Cognition-Enhancing Drugs and Applications to AgingJelena Milic34. Creatine supplementation and impact on the aging brainB. Gualano35. Photobiomodulation as a brain-boosting strategy in agingSaeed Sadigh-Eteghad36. Innovation in deep brain stimulation in aging: a focus on Parkinson DiseasePaolo Amami37. Exergames: what they are and how they can be used to improve cognition in agingRenato Sobral Monteiro-Junior, Ana Rodrigues, Laís Felício, Luiz Figueiredo and Túlio Rocha38. Linking cognitive decline and ballroom dance as a therapeutic intervention in the elderlyJacqueline C. Dominguez39. Active experiencing training in the elderlyMaria Requena40. Psychiatric self-management, smartphone apps and older adultsKaren Fortuna41. Psychosocial Interventions for Suicide Prevention in the Elderly: Advances and Future DirectionsD. Kiosses

V. Models And Modelling42. D-galactose-induced aging and brain mitochondriaFereshteh Farajdokht43. Drosophila as a model organism in ageing researchMaximo Ibo Galindo44. The Zebrafish (Danio rerio) and its uses for understanding the neuroscience of aging: applications and observationMichelle M. Adams45. Murine models of primary Tauopathy as a model of agingDavid Westaway46. Modelling nutrition and brain aging in rodentsDevin Wahl47. Modelling primates and neurological aging: a focus on Alzheimer's diseaseMelissa K. Edler48. Linking aging and animal models to neurodegeneration: the Striatum, Substantia Nigra and Parkinson's DiseaseRodrigo Portes Ureshino49. Behavioral evaluation of agingAna Perez-Villalba

VI. Resources50. Research and recommended resources in the neuroscience of agingRajkumar RajendramFactors Affecting Neurological Aging: Genetics, Neurology, Behavior, And Diet

I. Genetics, Molecular and Cellular Biology1. Genetics of frontotemporal dementiaEbru Erzurumluoglu Gokalp, Demet Adapinar and Sevilhan Artan2. Aging, brain-derived neurotrophic factor (BDNF) and its polymorphismTing Shen3. Aging, demented patients, and polymorphisms in cytokine genes Karina Braga Borges4. RNA fragments and brain agingAndrey Grigoriev5. Centrosome functions and remodeling during neuronal development and centrosome abnormalities in neuronal disorders, disease, and in agingH. Schatten6. Brain aging and microarray analysisMichelino Di Rosa7. Human nuclear tau and agingSalvatore Saccone8. Lipoxidation: features, neurological tissues and aging Reinald Pamplona Sr.9. Aging and brain amino acidsM. Furuse10. How 3’,5’-cyclic nucleotide phosphodiesterases change in the brain with normal aging and dementiaMichy Kelly11. The prohibitin complex in aging and neurodegenerationEnrique Santamaría12. Synaptic ATPase and energy metabolism in the nervous system: roles and changes in the aging process Roberto Villa and Federica Ferrari

II. Neurological and Imaging Features13. Microstructural Imaging of the Human Brain with Normal and "Abnormal" Aging using Diffusion Magnetic Resonance ImagingYu-Chien Wu14. Imaging the brain and its vascular in aging: applications of optical coherence tomography angiographyRuikang Wang15. Potential involvement of perineuronal nets in brain aging: an anatomical point of view Shozo Jinno16. Grey-matter networks in agingMarisa Koini17. Brain synapse-related proteins what they do and how they change in aging Yoshimi Takai18. Macro- and chaperone-mediated autophagy in agingBen Loos19. Neuronal L-type calcium channels in aging Tuck Wah Soong20. D-serine-regulated glutamatergic transmission and microglia: impact of agingJaime L. Eugenin21. Voltage-gated potassium channels and the aging brainFederico Sesti22. Dendritic spine remodeling and agingJeremy Herskowitz23. High-density lipoprotein-cholesterol and neuroaging: memory, gyrification of the insular and frontal opercular cortexRyuta Kinno24. Astrocyte and microglial aging: morphology and modelling A. MacLean25. Neural scaffolding: features, profiles and the aging cerebellumPavel Filip26. BACE1 RNAi, memory and aging P. Cardona-Gomez27. Aging, myelination and the optic nerveH. Attia and Ahmed Abdellatif28. Linking proteostasis, brain aging, and ischemiaWei Yang29. Luteinizing hormone and the aging nervous systemG. Casadesus30. Insights into aging using transcranial magnetic stimulationD. Blumberger31. Alpha rhythms: What they are and how they alter with agingMaria Knyazeva32. Nicotine and its derivatives in healthy brain aging Saeed Sadigh-Eteghad

III. Physiological Aspects 33. Environmental enrichment and physiological agingAlla Salmina34. Treadmill exercise and neuroinflammation: links with agingCaroline Real35. Impact of aerobic exercise on brain structure in models of aging: hippocampus and beyondLars S. Stiernman, Chelsea Stillman and Kirk Erickson36. The physiology of fitness and the brain in agingMonica Fabiani37. Aging, Babble Noise and the processing of speech perceptionA. N. Yusoff38. The blood-brain barrier in agingF. Erdo

IV. Behavior And Psychopathological Aspects 39. Linking aging, anticholinergic drug use, and cognitive impairmentVirginia Boccardi40. Cognitive Frailty: Definition, components and impact on disability, and mortalityFrancesco Panza41. The physiology of the "Brain-muscle loop" in agingF. Lauretani42. Disentangling the effects of aging and ovarian hormone loss on sleep: Implications for health and diseaseNicole Gervais43. Role of DNA methylation in aging-related cognitive functioning'Anna Starnawska44. Depression in the elderly and psychobioticsElnaz Vaghef-Mehrabany

V. Diet And Nutrition45. Aging, dietary patterns and cognitionAngela Marie Abbatecola46. Geriatric nutritional risk index: Application, and limitationsElnaz Vaghef-Mehrabany47. Diet, inflammatory biomarkers, and brain agingYian Gu48. DASH diet and brain agingStephanie Ruth Rainey-Smith49. The ketogenic diet and healthy brain aging Georgia Anne Francis Rogerson50. Autophagy and aging: diet, exercise, and the link with the target of rapamycin complex 1 (TORC)Kurt Anthony Escobar51. Dietary Flavonoids and Brain Health in Ageing: food for ThoughtJustin S. Rhodes and Catarina Rendeiro52. Antioxidant effects of curcumin and neuroagingShameemah Abrahams53. Lipoic acid and vitamin D3 and their use in preventing brain agingFrancesca Uberti54. Aging and working memory: impact of the leucine metabolite beta hydroxy-beta-methyl butyrateJoshua M. Gulley and Roberto Galvez55. Hydration, the brain and aging Agata Białecka-Dębek

Colin R Martin

Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.

Affiliations and expertise

Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

Victor R Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.

Affiliations and expertise

Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK Visiting Professor, University of Hull, UK

Rajkumar Rajendram

Dr Rajkumar Rajendram is a clinician scientist with a focus on internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St. Thomas Medical School, King’s College London in 2001. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram subsequently practiced as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford.

Dr Rajendram also trained in anaesthesia and intensive care in London and was awarded a fellowship of the Royal College of Anaesthetists (FRCA) in 2009. He completed advanced training in regional anaesthesia and intensive care. He was awarded a fellowship of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014. He then moved to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He has been a fellow of the Royal College of Physicians of Edinburgh (FRCP Edin) and the Royal College of Physicians of London (FRCP Lond) since 2017 and 2019 respectively. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.

Dr Rajendram’s focus on improving outcomes from Coronavirus Disease 2019 (COVID-19) has involved research on point of care ultrasound and phenotypes of COVID-19. Dr Rajendram also recognises that nutritional support is a fundamental aspect of medical care. This is particularly important for patients with COVID-19. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is an affiliated member of the Nutritional Sciences Research Division of King’s College London and has published over 400 textbook chapters, review articles, peer-reviewed papers and abstracts.

Affiliations and expertise

Consultant in Internal Medicine, King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia