The Neurobiology of the Gilles De La Tourette Syndrome and Chronic Tics: Part A

The Neurobiology of the Gilles De La Tourette Syndrome and Chronic Tics: Part A

1st Edition - July 1, 2022

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  • Editors: Marc Lavoie, Andrea Cavanna
  • Hardcover ISBN: 9780323910347

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The Neurobiology of the Gilles de la Tourette Syndrome and Chronic Tics, Volume Three reviews historical background and current nosology and guidelines. In addition, it includes an overview of pathophysiology, ranging from its genetic basis and changes in neurochemistry and electrophysiology to widespread neural circuits. Specific chapters cover Tourette syndrome from phenomenology and natural history to neurobiology, Update and Recent progress in the Neurobiology of Tourette Syndrome, Current guidelines and nosology of Tourette syndrome, Neuroimaging applications in Tourette's Syndrome, Clinical and neurodevelopmental brain imaging of Tourette syndrome, Altered Structural Connectivity in Gilles de la Tourette Syndrome, and much more. The last 20 years have seen an exponential growing body of research dedicated to Gilles de la Tourette Syndrome in the understanding of the syndrome’s complex genetics and underlying neurobiology. This unprecedented surge in basic and clinical research has resulted in over 3,000 scientific publications.

Key Features

  • Examines Gilles de la Tourette Syndrome at behavioral, cognitive, clinical, electrophysiological, molecular and genetic levels
  • Provides a comprehensive overview of the neurobiological aspects of Gilles de la Tourette Syndrome
  • Edited and authored by top researchers and clinicians treating the Gilles de la Tourette Syndrome


Researchers, Physicians, Psychiatrists, Neurologists, Neuropsychologist, Geneticists, Neuroscientists, Professors in psychiatry and psychology, medical residents

Table of Contents

  • Preface

    Marc E. Lavoie and Andrea E. Cavanna

    Section I: Introduction and clinical definition

    1. Historical background of the Gilles de la Tourette syndrome

    Olivier Walusinski

    2. The neurobiology of Gilles de la Tourette syndrome and chronic tics

    James F. Leckman

    3. Tourette syndrome: Current nosology and guidelines

    Andrea E. Cavanna

    4. Update and recent progress in the neurobiology of Tourette syndrome

    Natalia Szejko

    Section II: Neuroimaging and pathophysiology

    5. Recent advances in neuroimaging of Tourette syndrome

    Nicholas Cothros and Davide Martino

    6. Mechanistic insight into the pathophysiological basis of Tourette syndrome

    Charlotte L. Rae and Hugo D. Critchley

    7. Course of TS from a clinical and neuroimaging perspective

    Laura Bogut Andersen, Camilla Groth, Liselotte Skov and Nanette Mol Debes

    8. Altered structural connectivity in Gilles de la Tourette syndrome

    Yulia Worbe

    9. The neural correlates of tic inhibition

    Elia Abi-Jaoude and Paul Sandor

    Section III: The structure and function of neural circuits: Data from neuroimaging and electrophysiology

    10. Somatomotor cortical mapping in Tourette syndrome using neuro-navigated transcranial magnetic stimulation

    Caitlin M. Smith, Hilmar P. Sigurdsson, Katherine Dyke, Rosa Sanchez Panchuelo, Susan T. Francis, Georgina M. Jackson and Stephen R. Jackson

    11. Control of actions and tics: A psychophysiological perspective

    Simon Morand-Beaulieu, Rebecca P. Jordan, Elinor Baldwin, Julia Zhong and Denis G. Sukhodolsky

    12.Integrating psychophysiology into cognitive-behavioral treatment for the Gilles de la Tourette syndrome

    Marc E. Lavoie, Marie-Ange Perrault and Julie Leclerc

    13. The functional neuroimaging of Tourette syndrome and obsessive-compulsive disorder

    Tracy Bhikram

    14. Co-occurring ADHD symptoms and electrophysiological correlates of cognitive control in Tourette syndrome

    Elizabeth Shephard, Madeleine J Groom and Georgina M Jackson

Product details

  • No. of pages: 422
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: July 1, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780323910347

About the Serial Volume Editors

Marc Lavoie

Marc Lavoie
Marc E. Lavoie, PhD is currently research professor of Psychiatry and Neuroscience at the University of Montréal, and since 2001 he is directing the Cognitive and Social Psychophysiology Laboratory, at the research center of the Institut Universitaire en Santé Mentale de Montréal (Canada). His research training was completed in the field of psychophysics (Université de Moncton, Canada), experimental neuropsychology (Université de Montréal, Canada), developmental psychology (Universiteit van Amsterdam, the Nederland) and in psychobiology (Université de Lille, France). He directs a clinical research program currently funded by the Canadian Institutes of Health Research that addresses crucial issues about the relationship between brain functions, behavior, and cognition in various neurodevelopmental and habit disorders, primarily in Tourette’s syndrome and behavior-focused repetitive behavior.

Affiliations and Expertise

Centre de Recherche de l’Institut Universitaire en Sante Mentale de Montreal, Departement de Psychiatrie et Addictologie, Universite de Montreal, Quebec, Canada

Andrea Cavanna

Andrea Cavanna
Andrea E. Cavanna, MD, PhD, FRCP, FANPA, SFHEA, works as a clinician (Consultant in Behavioural Neurology at the Department of Neuropsychiatry, National Centre for Mental Health, Birmingham, UK) and as an academic (Honorary Professor in Neuropsychiatry at Aston University, Birmingham, UK). His medical training was completed in Italy (University of Turin and A. Avogadro University, Novara) and in the United Kingdom (University College London). Since 2008 he has been Lead Consultant for the specialist Tourette syndrome clinic. His research activity focuses on the behavioural aspects of neurological conditions. He coordinates training activities directed at the future generation of clinical scientists by running the Tourette syndrome module of the MSc in Clinical Neuropsychiatry at the University of Birmingham.

Affiliations and Expertise

Honorary Professor in Neuropsychiatry at Aston University, Birmingham, UK

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