The Nervous System

The Nervous System

Autonomic Nervous System Drugs

1st Edition - January 1, 1967

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  • Editors: Walter S. Root, Frederick G. Hofmann
  • eBook ISBN: 9781483272948

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Physiological Pharmacology: A Comprehensive Treatise, Volume III: The Nervous System — Part C: Autonomic Nervous System Drugs focuses on the effects of drugs on the nervous system, including cardiovascular effects and metabolism. The selection first offers information on the cardiovascular effects of choline esters and the effects of choline esters on smooth muscles and secretions. Topics include actions of acetylcholine, physiological role of choline esters, and actions of cholinergic drugs on smooth muscles and secretions. The book also takes a look at the pharmacologic, toxicologic, and therapeutic properties of anticholinesterase agents, including the chemistry and metabolism of anticholinesterase substances and mechanisms of action of anticholinesterase agents and role of cholinesterases. The publication examines muscarinic blocking drugs and ganglion-blocking drugs. Discussions focus on actions on the secretory glands and cardiovascular system; distribution, metabolism, and excretion of atropine; substances that block ganglionic transmission; and cardiovascular effects. The text also elaborates on neuromuscular blocking drugs. The selection is a dependable reference for readers interested in the effects of drugs on the nervous system.

Table of Contents

  • Contributors to Volume III


    Contents of Previous Volumes

    I. Cholinergic Drugs

    A. Cardiovascular Effects of Choline Esters

    I. Introduction

    II. Actions of Acetylcholine

    III. Esters Related to Acetylcholine

    IV. On the Physiological Role of Choline Esters


    B. Effects of Choline Esters on Smooth Muscle and Secretions

    I. Introduction

    II. The Actions of Cholinergic Drugs on Smooth Muscle

    III. The Action of Cholinergic Drugs on Secretions


    C. Pharmacologic, Toxicologic, and Therapeutic Properties of Anticholinesterase Agents

    I. Introduction

    II. Activities of Cholinesterases, Their Inhibition and Reactivation

    III. Distribution of Cholinesterases

    IV. Distribution of Choline Acetylase and of Acetylcholine

    V. Chemistry and Metabolism of Anticholinesterase Substances

    VI. Special Pharmacology of Anticholinesterases

    VII. Therapeutics

    VIII. Toxicity and its Treatment

    IX. Mechanisms of Action of Anticholinesterase Agents and Role of Cholinesterases


    II. Cholinergic Blocking Drugs

    A. Muscarinic Blocking Drugs

    I. Introduction

    II. Sources

    III. History

    IV. Chemistry

    V. Mechanism of Action

    VI. Actions on the Secretory Glands

    VII. Actions on Smooth Muscle

    VIII. Actions on the Cardiovascular System

    IX. Actions on the Central Nervous System

    X. Actions on Other Nervous Tissues

    XI. Distribution, Metabolism, and Excretion of Atropine


    B. Ganglion-Blocking Drugs

    I. Introduction

    II. Substances Which Block Ganglionic Transmission

    III. Effects of Ganglion Blockade

    IV. Mode of Action

    V. Cardiovascular Effects

    VI. Selective Blockade of Sympathetic and Parasympathetic Ganglia

    VII. Absorption, Distribution, and Excretion

    VIII. Side Effects


    C. Neuromuscular Blocking Drugs

    I. Physiology of Neuromuscular Transmission

    II. Causes of Neuromuscular Block

    III. Neuromuscular Blocking Agents that Act Presynaptically

    IV. Neuromuscular Blocking Agents that Act Postsynaptically


    Author Index

    Subject Index

Product details

  • No. of pages: 534
  • Language: English
  • Copyright: © Academic Press 1967
  • Published: January 1, 1967
  • Imprint: Academic Press
  • eBook ISBN: 9781483272948

About the Editors

Walter S. Root

Frederick G. Hofmann

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