The Nervous System

Contributors to Volume III

Foreword

Contents of Previous Volumes

I. Cholinergic Drugs

A. Cardiovascular Effects of Choline Esters

I. Introduction

II. Actions of Acetylcholine

III. Esters Related to Acetylcholine

IV. On the Physiological Role of Choline Esters

References

B. Effects of Choline Esters on Smooth Muscle and Secretions

I. Introduction

II. The Actions of Cholinergic Drugs on Smooth Muscle

III. The Action of Cholinergic Drugs on Secretions

References

C. Pharmacologic, Toxicologic, and Therapeutic Properties of Anticholinesterase Agents

I. Introduction

II. Activities of Cholinesterases, Their Inhibition and Reactivation

III. Distribution of Cholinesterases

IV. Distribution of Choline Acetylase and of Acetylcholine

V. Chemistry and Metabolism of Anticholinesterase Substances

VI. Special Pharmacology of Anticholinesterases

VII. Therapeutics

VIII. Toxicity and its Treatment

IX. Mechanisms of Action of Anticholinesterase Agents and Role of Cholinesterases

References

II. Cholinergic Blocking Drugs

A. Muscarinic Blocking Drugs

I. Introduction

II. Sources

III. History

IV. Chemistry

V. Mechanism of Action

VI. Actions on the Secretory Glands

VII. Actions on Smooth Muscle

VIII. Actions on the Cardiovascular System

IX. Actions on the Central Nervous System

X. Actions on Other Nervous Tissues

XI. Distribution, Metabolism, and Excretion of Atropine

References

B. Ganglion-Blocking Drugs

I. Introduction

II. Substances Which Block Ganglionic Transmission

III. Effects of Ganglion Blockade

IV. Mode of Action

V. Cardiovascular Effects

VI. Selective Blockade of Sympathetic and Parasympathetic Ganglia

VII. Absorption, Distribution, and Excretion

VIII. Side Effects

References

C. Neuromuscular Blocking Drugs

I. Physiology of Neuromuscular Transmission

II. Causes of Neuromuscular Block

III. Neuromuscular Blocking Agents that Act Presynaptically

IV. Neuromuscular Blocking Agents that Act Postsynaptically

References

Author Index

Subject Index