The Mouse Nervous System

1st Edition

Print ISBN: 9780123694973
eBook ISBN: 9780080919188
Imprint: Academic Press
Published Date: 23rd November 2011
Page Count: 814
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The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience.

Key Features

  • Systematic consideration of the anatomy and connections of all regions of the brain and spinal cord by the authors of the most cited rodent brain atlases
  • A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states
  • A detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area
  • Full coverage of the role of gene expression during development and the new field of genetic neuroanatomy using site-specific recombinases
  • Examples of the use of mouse models in the study of neurological illness


Neuroscientists, neuropathologists, neurologists, graduate students in neuroscience, and medical students.

Table of Contents


List of Contributors



Chapter 1. Molecular Regionalization of the Developing Neural Tube

Chapter 2. Gene Targeting

Chapter 3. Genetic Neuroanatomy

Chapter 4. Neocortex

Chapter 5. Hippocampus

Chapter 6. Piriform Cortex and Amygdala

Chapter 7. Subpallial Structures

Chapter 8. Hypothalamus

Chapter 9. Diencephalon

Chapter 10. Midbrain

Chapter 11. Cerebellum

Chapter 12. Hindbrain

Chapter 13. Spinal Cord

Chapter 14. Vascular Supply

Chapter 15. Magnetic Resonance Imaging of the Mouse Brain

Chapter 16. Motor Nuclei of the Cranial Nerves

Chapter 17. Visceral Motoneurons

Chapter 18. Neurosecretory Nuclei of the Hypothalamus and Preoptic Area

Chapter 19. Motor Cortex

Chapter 20. Hypothalamic Goal-directed Behavior – Ingestive, Reproductive and Defensive

Chapter 21. The Somatosensory System

Chapter 22. Gustatory

Chapter 23. Pain

Chapter 24. Auditory System

Chapter 25. Visual System

Chapter 26. The Olfactory System

Chapter 27. Vestibular System

Chapter 28. The Basal Forebrain Cholinergic Projection System in Mice

Chapter 29. An Introduction to the Neurobiology of Emotions and Social Behavior

Chapter 30. Prefrontal Cortex

Chapter 31. Overview of Mouse Models for Psychiatric and Neurologic Disorders

Chapter 32. Mouse Models of Mental Illness and Neurological Disease

Chapter 33. The Neuroanatomy of Addictive Processes



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A mouse may appear insignificant due to its small size, but its complex nervous system has played a significant role in neuroscience studies. Such a system is intricate enough for a book, the thickness of 4 adult mice lying on top of one another, to be written about it. There were three main reasons for such a book: it would serve as an introductory guide to neuroscience for molecular biologists, provide insight on the new discoveries of gene expression, and highlight that mice are unique as compared to the more commonly studied rats. The Mouse Nervous System, edited by Charles Watson, George Paxinos, and Luis Puelles, does just that by thoroughly venturing through the crevices of the central nervous system of the mouse.

To the general public, the mouse brain may appear to be a simple chunk of mass, but neurologists and anatomists would beg to differ. This book, having been composed by professionals in the fields of neurology and anatomy, shows how complicated the mouse brain actually is. Of the 33 chapters devoted to the anatomy of the mouse brain, the first three are about its stages of development. These earlier chapters also include past experiments which provide support for the facts about development. For more than half of the book, from chapter four until chapter fifteen, the structure of the brain is presented as a whole and then as individual parts. Thus, the text and real life anatomy figures both serve as dissections of the mouse brain. Furthermore, images throughout the book are useful and relevant not only to those who learn from viewing pictures but also serve as supplemental information for those who learn from reading text.

After introducing the reader to the fundamentals of the mouse brain, the systems and their respective functions are presented in chapters 16 through 27. With most important information already provided in the first half of the book, these later chapters serve to assist the reader in connecting the dots