The Mouse in Biomedical Research

The Mouse in Biomedical Research

Normative Biology, Husbandry, and Models

2nd Edition - November 30, 2006

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  • Editors: James Fox, Stephen Barthold, Muriel Davisson, Christian Newcomer, Fred Quimby, Abigail Smith
  • eBook ISBN: 9780080469072
  • Hardcover ISBN: 9780123694577

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Description

Normative Biology, Husbandry, and Models, the third volume in the four volume set, The Mouse in Biomedical Research, encompasses 23 chapters whose contents provide a broad overview on the laboratory mouse’s normative biology, husbandry, and its use as a model in biomedical research. This consists of chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. Other chapters cover management, as well as nutrition, gnotobiotics and disease surveillance. There are also individual chapters describing the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases. Chapters on imaging techniques and the use of the mouse in assays of biological products are also included.

Readership

Veterinary and medical students, senior graduate, graduate students, post-docs, and researchers who utilize animals in biomedical research

Table of Contents

  • List of Reviewers for Chapters in this Volume

    Contributors

    Foreword for Volume III

    Preface

    Normative Biology

    Chapter 1: Gross Anatomy

    INTRODUCTION

    ACKNOWLEDGMENT

    Chapter 2: Mouse Physiology

    I. CARDIOVASCULAR SYSTEM

    II. RESPIRATORY PHYSIOLOGY

    III. THE DIGESTIVE SYSTEM

    IV. METABOLISM: THE PROBLEM OF SIZE

    V. THERMOREGULATION

    VI. RENAL PHYSIOLOGY*

    VII. WATER REGULATION

    ACKNOWLEDGMENTS

    Chapter 3: Reproductive Biology of the Laboratory Mouse

    I. ONTOGENY OF THE REPRODUCTIVE SYSTEM

    II. ORGANIZATION AND FUNCTION OF THE REPRODUCTIVE TRACT

    III. MANAGING REPRODUCTION IN MICE

    ACKNOWLEDGMENTS

    Chapter 4: Endocrinology: Bone as a Target Tissue for Hormonal Regulation

    I. OVERVIEW

    II. BONE CELLULAR ORGANIZATION AND ACTIVITY

    III. HORMONAL ACTIONS ON BONE

    H. 1,25-Dihydroxy Vitamin D3 [1,25(OH)2D3]

    IV. SUMMARY

    Chapter 5: Hematology of the Laboratory Mouse

    I. INTRODUCTION

    II. GENERAL CONSIDERATIONS FOR MURINE HEMATOLOGY

    III. TECHNIQUES IN HEMATOLOGY

    IV. ERYTHROCYTES

    V. LEUKOCYTES

    VI. PLATELETS

    VII. HEMOSTASIS

    VIII. HEMATOLOGY OF THE MOUSE EMBRYO

    IX. HEMATOLOGY OF YOUNG MICE

    X. HEMATOLOGY OF AGING MICE

    XI. THE ROLE OF THE SPLEEN IN MURINE HEMATOPOIESIS

    XII. CONCLUSIONS

    ACKNOWLEDGMENTS

    Chapter 6: Clinical Chemistry of the Laboratory Mouse

    I. INTRODUCTION

    II. METHODS OF ANALYSIS AND INSTRUMENTATION

    III. SAMPLING

    IV. REFERENCE RANGES

    V. SPECIFIC TESTS

    Management, Techniques, and Husbandry

    Chapter 7: Gnotobiotics

    I. TERMINOLOGY

    II. HISTORICAL HIGHLIGHTS IN GNOTOBIOTICS

    III. ISOLATOR TECHNOLOGY

    IV. DERIVATION OF GNOTOBIOTIC MICE

    V. ASSOCIATING GERMFREE MICE WITH DEFINED FLORA

    VI. MONITORING FOR ISOLATOR CONTAMINATION

    VII. ASSOCIATION FOR GNOTOBIOTICS

    Chapter 8: Management and Design: Breeding Facilities

    I. INTRODUCTION

    II. FACILITIES FOR BREEDING MICE

    III. MICROBIOLOGIC STATUS

    IV. ESTABLISHING A BREEDING COLONY

    V. GENETIC QUALITY CONTROL

    Chapter 9: Design and Management of Research Facilities for Mice

    I. INTRODUCTION

    II. ARCHITECTURE AND ENGINEERING

    III. ENVIRONMENTAL CONTROL AND MONITORING

    IV. EQUIPMENT

    V. MATERIALS

    VI. OPERATIONAL ISSUES

    VII. ENVIRONMENTAL ENRICHMENT

    VIII. CONCLUSION

    Chapter 10: Nutrition

    I. INTRODUCTION

    II. NUTRIENTS: MEASUREMENT AND REQUIREMENTS

    III. CONTAMINANTS IN DIET

    IV. LABORATORY TESTING

    V. DIET TYPES AND FORMULAS

    VI. DIET MANUFACTURE

    VII. STORAGE OF DIET

    VIII. DECONTAMINATION OF DIET

    IX. DIET RESTRICTION

    X. INFLUENCE OF DIET ON INFECTIOUS DISEASES AND IMMUNITY

    XI. WATER

    XII. CONCLUDING COMMENTS

    Chapter 11: Health Delivery and Quality Assurance Programs for Mice

    I. INTRODUCTION

    II. HEALTH CARE PROVISION FOR EXPERIMENTAL MICE

    III. QUALITY ASSURANCE (QA) PROGRAMS FOR MICE

    IV. INFECTIOUS OUTBREAK SOURCES AND MANAGEMENT

    V. LIMITATIONS OF OUR CURRENT KNOWLEDGE AND FUTURE DIRECTIONS

    Chapter 12: Environmental and Equipment Monitoring

    I. INTRODUCTION

    II. MANAGEMENT

    III. ENVIRONMENTAL FACTORS

    IV. EQUIPMENT AND SYSTEMS

    V. FEED AND BEDDING

    VI. SANITATION

    VII. MONITORING FOR PESTS

    VIII. CONCLUSION

    Chapter 13: Biomethodology and Surgical Techniques

    I. INTRODUCTION

    II. HANDLING, IDENTIFICATION, AND RESTRAINT

    III. DRUG ADMINISTRATION

    IV. COLLECTION OF BIOLOGIC SPECIMENS

    V. ANESTHESIA

    VI. SURGICAL PROCEDURES

    VII. POSTANESTHETIC AND POSTOPERATIVE CARE

    VIII. EUTHANASIA

    IX. NECROPSY

    Chapter 14: In-Vivo Whole-Body Imaging of the Laboratory Mouse

    I. INTRODUCTION

    II. GENERAL FEATURES

    III. ADVANTAGES AND OPPORTUNITIES

    IV. DISADVANTAGES AND CHALLENGES

    V. LOGISTICAL ASPECTS

    VI. X-RAY IMAGING, INCLUDING X-RAY COMPUTED TOMOGRAPHY

    VII. ULTRASOUND

    VIII. MAGNETIC RESONANCE IMAGING

    IX. NUCLEAR IMAGING

    X. OPTICAL IMAGING

    XI. MULTIMODALITY IMAGING

    XII. SUMMARY

    ACKNOWLEDGMENTS

    Use of Mice in Biomedical Research

    Chapter 15: Behavioral Testing

    I. BEHAVIORAL PHENOTYPES

    II. APPROACHES TO MEASURING BEHAVIOR

    III. BEHAVIORAL DOMAINS AND SUBDOMAINS

    IV. MEASURING BEHAVIOR

    V. PLANNING BEHAVIORAL EXPERIMENTS

    VI. CONDUCTING A BEHAVIORAL TEST

    VII. SOURCES OF INFORMATION

    VIII. CONCLUSIONS AND RECOMMENDATIONS

    ACKNOWLEDGMENT

    Chapter 16: Cardiovascular Disease: Mouse Models of Atherosclerosis

    I. INTRODUCTION

    II. MOUSE MODELS OF ATHEROSCLEROSIS

    III. MODIFIERS OF ATHEROSCLEROSIS

    IV. INDUCTION OF CVD IN ATHEROSCLEROTIC MICE

    V. SUMMARY AND PERSPECTIVE

    Chapter 17: Convulsive Disorders

    I. INTRODUCTION

    II. HOMOLOGOUS MOUSE MODELS OF HUMAN EPILEPSY

    III. ORPHAN MOUSE MUTANTS

    IV. MULTIFACTORIAL EPILEPSY

    V. CONCLUSION

    ACKNOWLEDGMENTS

    Chapter 18: Eye Research

    I. INTRODUCTION

    II. RELEVANCE OF MICE IN EYE RESEARCH

    III. PHENOTYPIC EFFECTS PRODUCED BY STRAIN BACKGROUND AND STOCHASTIC EVENTS

    IV. OCULAR ANGIOGENESIS

    V. GLAUCOMA MODELS

    VI. MOLECULAR MECHANISMS IN RETINAL DEGENERATION

    Chapter 19: Genetic Analysis of Rodent Obesity and Diabetes

    I. THE OBESITY AND DIABETES CRISIS

    II. OBESITY IS INFLUENCED BY MANY GENES

    III. MOUSE MODELS OF OBESITY AND DIABETES USED IN GENETIC ANALYSIS

    IV. FUTURE DIRECTIONS

    Chapter 20: Mouse Models in Aging Research

    I. INTRODUCTION

    II. AGING, SENESCENCE, AND DISEASE: DEFINITIONS AND APPLICATION TO AGING RESEARCH

    III. BASICS OF EXPERIMENTAL DESIGN AND HUSBANDRY IN AGING RESEARCH

    IV. EXAMPLES OF GERONTOLOGIC STUDIES AND MOUSE MODELS USED

    V. SUMMARY AND CONCLUSIONS

    Chapter 21: Mouse Models of Inherited Human Neurodegenerative Disease

    I. INTRODUCTION

    II. INHERITED DEVELOPMENTAL DEGENERATIONS OF THE MOUSE

    III. MOUSE MODELS OF INHERITED HUMAN NEURODEGENERATION

    IV. CONCLUSIONS

    Chapter 22: Mouse Skin Ectodermal Organs

    I. INTRODUCTION

    II. HAIR FOLLICLES

    III. SEBACEOUS GLANDS

    IV. INTERFOLLICULAR SKIN

    V. SWEAT GLANDS

    VI. NAILS

    VII. VOLAR PADS

    VIII. MAMMARY GLANDS

    IX. CONCLUSION

    ACKNOWLEDGMENTS

    Chapter 23: Quality Control Testing of Biologics

    I. INTRODUCTION

    II. OVERVIEW OF MICROBIOLOGIC QUALITY CONTROL

    III. PRODUCTION

    IV. MICROBIOLOGIC QUALITY CONTROL TESTING

    V. NONMICROBIOLOGIC QUALITY CONTROL TESTING

    VI. INVESTIGATION OF OUT-OF-SPECIFICATION (OOS) RESULTS

    Index

Product details

  • No. of pages: 816
  • Language: English
  • Copyright: © Academic Press 2006
  • Published: November 30, 2006
  • Imprint: Academic Press
  • eBook ISBN: 9780080469072
  • Hardcover ISBN: 9780123694577

About the Serial Volume Editors

James Fox

James G. Fox, DVM, MS, DACLAM, is a Professor and Director of the Division of Comparative Medicine and a Professor in the Division of Biological Engineering at the Massachusetts Institute of Technology. He is also an Adjunct Professor at Tufts University School of Veterinary Medicine and the University of Pennsylvania, School of Veterinary Medicine. He is a Diplomate and a past president of the American College of Laboratory Animal Medicine, past president of the Massachusetts Society of Medical Research, past chairman of AAALAC Council, and past chairman of the NCCR/NIH Comparative Medicine Study Section. He also is an elected fellow of the Infectious Disease Society of America. Professor Fox is the author of over 490 articles, 80 chapters, 3 patents and has edited and authored 13 texts in the field of in vivo model development and comparative medicine.

Affiliations and Expertise

Massachusetts Institute of Technology, Cambridge, MA, USA

Stephen Barthold

Affiliations and Expertise

Center for Comparative Medicine, UC Davis School of Veterinary Medicine, Davis CA

Muriel Davisson

Affiliations and Expertise

The Jackson Laboratory, Bar Harbor, Maine

Christian Newcomer

Affiliations and Expertise

Research Animal Resources and Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD

Fred Quimby

Affiliations and Expertise

Laboratory Animal Research Center, The Rockefeller University, New York, NY

Abigail Smith

Affiliations and Expertise

School of Veterinary Medicine, University of Pennsylvania Philadelphia, PA

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