The Molecular Nutrition of Fats

The Molecular Nutrition of Fats

1st Edition - October 29, 2018

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  • Editor: Vinod Patel
  • Paperback ISBN: 9780128112977
  • eBook ISBN: 9780128112984

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Description

The Molecular Nutrition of Fats presents the nutritional and molecular aspects of fats by assessing their dietary components, their structural and metabolic effects on the cell, and their role in health and disease. Subject areas include molecular mechanisms, membranes, polymorphisms, SNPs, genomic wide analysis, genotypes, gene expression, genetic modifications and other aspects. The book is divided into three sections, providing information on the general and introductory aspects, the molecular biology of the cell, and the genetic machinery and its function. Topics discussed include lipid-related molecules, dietary lipids and lipid metabolism, high fat diets, choline, cholesterol, membranes, trans-and saturated fatty acids, and lipid rafts. Other sections provide comprehensive discussions on G protein-coupled receptors, micro RNA, transcriptomics, transcriptional factors, cholesterol, triacylglycerols, beta-oxidation, cholesteryl ester transfer, beta-oxidation, lysosomes, lipid droplets, insulin mTOR signaling and ligands, and more.

Key Features

  • Summarizes molecular nutrition in health as related to fats
  • Discusses the impact of fats on cancer, heart disease, dementia, and respiratory and intestinal disease
  • Includes preclinical, clinical and population studies
  • Covers the genome, the whole body and whole communities
  • Includes key facts, a mini dictionary of terms and summary points

Readership

Researchers, professionals (including nutritionists, dieticians, health scientists, health care professionals, policy makers), educators, and students

Table of Contents

  • Section 1: General and Introductory Aspects
    1. Intestinal health and bioactive lipids
    2. C-reactive protein and plasma fatty acids: public health concerns and implications
    3. The role of a fatty acid chain elongase, Elovl,1 in zebrafish and implications fcor human kidney
    4. Dietary lipids and lipid metabolism: An overview
    5. Fatty acids use in neurological disease
    6. The Neurocan-cartilage intermediate layer protein NCAN-CILP2 region and plasma lipid levels
    7. Role of cholesterol on controlling membrane phospholipid asymmetry
    8. Adipose tissue and peritoneal dialysis
    9. Lipid biomarkers and cancer
    10. Absorption of dietary fat and their metabolism in enterocytes
    11. The lipid-lowering action of iodothyronines
    12. Dietary Omega-3s and Muscle Composition in adults
    13. An overview of cholesterol absorption
    14. Triacylglycerols and use of docosahexaenoic acid at the sn-2 position
    15. Safety of Docosahexaenoic acid (DHA) ethyl ester and implications for human studies
    16. Fish oil supplementation and depression
    17. Drugs to counter SFA-mediated lipointoxication
    18. Lipoprotein (a) [Lp(a)]
    19. Endoplasmic reticulum (ER) stress, and white adipose tissue lipolysis
    20. Trans-fat intake and behaviour
    21. Glycemic index meal feeding and lipid profiling
    22. Beef Fat
    23. Lipid pathway in liver cells and its modulation by dietary extracts

    Section 2: Molecular Biology of the Cell
    24. Subcellular organelles: lipid droplets
    25. Optimized omega-3 EPA:DHA 6:1 and pulmonary arterial hypertension
    26. Omega-3 fatty acids and epilepsy
    27. Docosahexaenoic acid (DHA): A dietary supplement with promising anticancer potential
    28. Periaortic adipose tissue in obesogenic diets
    29. Genomics, statins and lipid metabolism
    30. Cholesterol metabolism in atherosclerosis development
    31. Lipid metabolism in dyslipidemia and familial hypercholesterolemia
    32. Lipid Profile of Progenitor Cells
    33. Trans-fatty acids and mortality
    34. Saturated and monounsaturated fatty acids associate with development and prematurity
    35. Hedgehog signaling and liver lipid metabolism
    36. Cyclosporin A-Induced Dyslipidemia and LDL Receptors
    37. Hypoxia and adipose tissue lipid breakdown
    38. Intramyocellular fat storage

    Section 3: Genetic Machinery and Its Function
    39. Fatty acid binding protein 2 genes and public health implications for diabetes
    40. Transcriptional factor modulation by lipid peroxidation-derived aldehydes
    41. Heterogeneity of white adipose tissue
    42. Nomenclature, classes and functions of lipids and lipid-related molecules, Dietary lipids
    43. Lipid metabolism: an overview - The mitochondria as a site of fatty acid beta-oxidation
    44. Fatty acids, gut bacteria and immune cell function

Product details

  • No. of pages: 470
  • Language: English
  • Copyright: © Academic Press 2018
  • Published: October 29, 2018
  • Imprint: Academic Press
  • Paperback ISBN: 9780128112977
  • eBook ISBN: 9780128112984

About the Editor

Vinod Patel

Dr. Patel is a Reader at the University of Westminster. After completing his PhD at King’s College London, he continued his research experience by undertaking his post-doctoral studies in the laboratory of Professor Cunningham in the Department of Biochemistry at the Wake Forest University School of Medicine, (Winston-Salem, NC, USA). This extensive project involved investigating mechanisms of hepatic mitochondrial ribosome dysfunction in alcoholic liver disease (ALD) using biophysical and proteomic techniques. These studies have led to new avenues in determining the pathology of ALD. His teaching areas at both post-graduate and undergraduate levels include clinical biochemistry, investigative pathology and laboratory investigation.

Affiliations and Expertise

Reader, University of Westminster, London, UK

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