The Molecular Biology of Arrestins, Volume 118

1st Edition

Print ISBN: 9780123944405
eBook ISBN: 9780123947895
Imprint: Academic Press
Published Date: 24th June 2013
Page Count: 536
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This special volume of Progress in Molecular Biology and Translational Science focuses on the molecular biology of arrestins, with contributions from leaders in the field. Arrestins have emerged as central players in the regulation of many facets of G protein-coupled receptor signaling. This volume covers a variety of topics with reviews written by experts in the field.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Students, researchers, microbiologists, molecular biologists

Table of Contents



Part I: Perspective - The Duality of Arrestin Function

Chapter One. Arrestins Come of Age: A Personal Historical Perspective

1 Introduction

2 “Prehistory” of Arrestins

3 A Family of 7 Transmembrane Receptors

4 The GRK and Arrestin Families

5 Arrestins and Desensitization

6 Arrestins and Endocytosis

7 Arrestins and Signaling

8 Biased Signaling

9 Bar Code Hypothesis

10 Other Receptors, Other Functions

11 Future Perspectives


Part II: The Molecular Biology of Arrestins

Chapter Two. True Arrestins and Arrestin-Fold Proteins: A Structure-Based Appraisal


1 Introduction

2 True Arrestins: A Structure Adapted to Multiple Scaffolding

3 Novel Arrestin-Related Proteins

4 Other Arrestin-Fold Proteins

5 Are Arrestins and Arrestin-Fold Proteins Related by a Shared Mechanism for Their Function?

6 Conclusion and Perspectives


Chapter Three. Structural Determinants of Arrestin Functions

1 Introduction

2 What the Crystal Structure Reveals, and What It Does Not

3 How Do Arrestins Fit Receptors?

4 Interactions with Other Signaling Proteins

5 Designing Signaling-Biased Arrestin Mutants

6 Conclusions: Where Do We Go from Here?



Chapter Four. Arrestins: Role in the Desensitization, Sequestration, and Vesicular Trafficking of G Protein-Coupled Receptors

1 Introduction

2 Arrestins in GPCR Desensitization

3 Arrestins in GPCR Trafficking

4 Conclusions



Chapter Five. Arrestins as Regulators of Kinases and Phosphatases

1 Introduction

2 Arrestins as GPCR Effectors

3 Positive and Negative Regulation of Kinase Pathways



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Praise for the series:
"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal