The Molecular Basis of Drug Addiction - 1st Edition - ISBN: 9780128037867, 9780128038680

The Molecular Basis of Drug Addiction, Volume 137

1st Edition

Authors: Shafiqur Rahman
eBook ISBN: 9780128038680
Hardcover ISBN: 9780128037867
Imprint: Academic Press
Published Date: 12th January 2016
Page Count: 277
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Table of Contents

  • Contributors
  • Preface
  • Chapter One: Molecular Mechanism: ERK Signaling, Drug Addiction, and Behavioral Effects
    • Abstract
    • Abbreviations
    • 1. Introduction
    • 2. ERK Signaling Pathway
    • 3. ERK Signaling and Drug Addiction
    • 4. Conclusions and Future Directions
    • Acknowledgment
  • Chapter Two: Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings
    • Abstract
    • 1. Alcoholism and Genetics
    • 2. Central Glutamatergic Activity
    • 3. Central Glutamate Activity and Alcohol Dependence
    • 4. Glutamate-Associated Genetic Variations and Alcoholism
    • 5. Alcohol and Glutamate Gene Expression
    • 6. Alcohol-Associated Changes in Gene/Protein Expression of P Rats
    • 7. Conclusions
    • Acknowledgments
  • Chapter Three: S-Glutathionylation and Redox Protein Signaling in Drug Addiction
    • Abstract
    • 1. Introduction
    • 2. Oxidative Stress
    • 3. S-Glutathionylation of Proteins Occurs in Response to Oxidative Stress
    • 4. S-Glutathionylation of Proteins is a Redox-Sensitive Signaling Mechanism in Cells
    • 5. S-Glutathionylation in Addiction-Related Protein Signaling
    • 6. S-Glutathionylation of PKA, PKC, Cdk5, and Actin May Influence Drug Behavior
    • 7. S-Glutathionylation in Alcohol Addiction
    • 8. S-Glutathionylation in Cocaine Addiction
    • 9. S-Glutathionylation in Heroin Addiction
    • 10. Future Research
    • 11. Conclusions
    • Acknowledgment
  • Chapter Four: Molecular Mechanisms of Cannabis Signaling in the Brain
    • Abstract
    • 1. Introduction
    • 2. Chemical Components of Cannabis
    • 3. Endocannabinoid System
    • 4. Signal Transduction
    • 5. CB1 Distribution
    • 6. CB2 Receptors
    • 7. Cannabis and Addiction
    • 8. Animal Models
    • 9. Molecular Adaptations to Chronic Use
    • 10. Synaptic Plasticity
    • 11. Cannabis Withdrawal
    • 12. Monoaminergic Systems
    • 13. Cannabidiol
    • 14. The Case of Charlotte's Web
    • 15. Conclusions
  • Chapter Five: The Nociceptin Receptor as an Emerging Molecular Target for Cocaine Addiction
    • Abstract
    • 1. Introduction
    • 2. Orphanin FQ/Nociceptin/NOPr System
    • 3. Molecular Mechanisms of Cocaine Addiction
    • 4. Conclusions
  • Chapter Six: Recent Advances in Nicotinic Receptor Signaling in Alcohol Abuse and Alcoholism
    • Abstract
    • 1. Introduction
    • 2. Mesolimbic-Dopamine System and nAChRs
    • 3. Knockout and Transgenic Models and nAChRs
    • 4. Alcohol, Nicotine Coabuse, and nAChRs
    • 5. Genetic Polymorphisms, Alcohol Dependence and nAChRs
    • 6. Alcohol Dependence, Comorbid Psychiatric Condition and nAChRs
    • 7. Alcohol, Transcription Factors, and nAChRs
    • 8. Conclusions
    • Acknowledgments
  • Chapter Seven: Molecular Changes in Opioid Addiction: The Role of Adenylyl Cyclase and cAMP/PKA System
    • Abstract
    • 1. Introduction
    • 2. The Adenylyl Cyclase Pathway
    • 3. Opioid Effect on cAMP-Responsive Element-Binding Protein (CREB)
    • 4. Molecular Changes in Brain Regions That May Underlie Opiate Dependence
    • 5. Molecular Changes in the Ventral Tegmental Area
    • 6. Molecular Changes in Other CNS Regions
    • 7. Conclusions
  • Chapter Eight: Caenorhabditis elegans as a Model to Study the Molecular and Genetic Mechanisms of Drug Addiction
    • Abstract
    • 1. Introduction
    • 2. Models of Addiction
    • 3. Invertebrate Models
    • 4. C. elegans as a Model System to Study Addiction
    • 5. Drugs of Abuse
    • 6. Convergent Mechanisms of Drugs of Abuse in C. elegans
    • 7. Leveraging C. elegans for Model Development and Drug Discovery
    • 8. Conclusions
    • Acknowledgment
  • Index

Description

This volume of Progress in Molecular Biology and Translational Science focuses on the molecular basis of drug addiction.

Key Features

  • Contains contributions from leading authorities
  • Informs and updates on all the latest developments in the field

Readership

Students, researchers, microbiologists, molecular biologists


Details

No. of pages:
277
Language:
English
Copyright:
© Academic Press 2016
Published:
Imprint:
Academic Press
eBook ISBN:
9780128038680
Hardcover ISBN:
9780128037867

About the Authors

Shafiqur Rahman Author

Professor Shafiqur Rahman works at the South Dakota State University, USA.

Affiliations and Expertise

Professor, Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD, USA