The Molecular Basis of Drug Addiction

The Molecular Basis of Drug Addiction

1st Edition - January 12, 2016
  • Author: Shafiqur Rahman
  • Hardcover ISBN: 9780128037867
  • eBook ISBN: 9780128038680

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Description

This volume of Progress in Molecular Biology and Translational Science focuses on the molecular basis of drug addiction.

Key Features

  • Contains contributions from leading authorities
  • Informs and updates on all the latest developments in the field

Readership

Students, researchers, microbiologists, molecular biologists

Table of Contents

  • Chapter One: Molecular Mechanism: ERK Signaling, Drug Addiction, and Behavioral Effects

    • Abstract
    • Abbreviations
    • 1. Introduction
    • 2. ERK Signaling Pathway
    • 3. ERK Signaling and Drug Addiction
    • 4. Conclusions and Future Directions
    • Acknowledgment

    Chapter Two: Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings

    • Abstract
    • 1. Alcoholism and Genetics
    • 2. Central Glutamatergic Activity
    • 3. Central Glutamate Activity and Alcohol Dependence
    • 4. Glutamate-Associated Genetic Variations and Alcoholism
    • 5. Alcohol and Glutamate Gene Expression
    • 6. Alcohol-Associated Changes in Gene/Protein Expression of P Rats
    • 7. Conclusions
    • Acknowledgments

    Chapter Three: S-Glutathionylation and Redox Protein Signaling in Drug Addiction

    • Abstract
    • 1. Introduction
    • 2. Oxidative Stress
    • 3. S-Glutathionylation of Proteins Occurs in Response to Oxidative Stress
    • 4. S-Glutathionylation of Proteins is a Redox-Sensitive Signaling Mechanism in Cells
    • 5. S-Glutathionylation in Addiction-Related Protein Signaling
    • 6. S-Glutathionylation of PKA, PKC, Cdk5, and Actin May Influence Drug Behavior
    • 7. S-Glutathionylation in Alcohol Addiction
    • 8. S-Glutathionylation in Cocaine Addiction
    • 9. S-Glutathionylation in Heroin Addiction
    • 10. Future Research
    • 11. Conclusions
    • Acknowledgment

    Chapter Four: Molecular Mechanisms of Cannabis Signaling in the Brain

    • Abstract
    • 1. Introduction
    • 2. Chemical Components of Cannabis
    • 3. Endocannabinoid System
    • 4. Signal Transduction
    • 5. CB1 Distribution
    • 6. CB2 Receptors
    • 7. Cannabis and Addiction
    • 8. Animal Models
    • 9. Molecular Adaptations to Chronic Use
    • 10. Synaptic Plasticity
    • 11. Cannabis Withdrawal
    • 12. Monoaminergic Systems
    • 13. Cannabidiol
    • 14. The Case of Charlotte's Web
    • 15. Conclusions

    Chapter Five: The Nociceptin Receptor as an Emerging Molecular Target for Cocaine Addiction

    • Abstract
    • 1. Introduction
    • 2. Orphanin FQ/Nociceptin/NOPr System
    • 3. Molecular Mechanisms of Cocaine Addiction
    • 4. Conclusions

    Chapter Six: Recent Advances in Nicotinic Receptor Signaling in Alcohol Abuse and Alcoholism

    • Abstract
    • 1. Introduction
    • 2. Mesolimbic-Dopamine System and nAChRs
    • 3. Knockout and Transgenic Models and nAChRs
    • 4. Alcohol, Nicotine Coabuse, and nAChRs
    • 5. Genetic Polymorphisms, Alcohol Dependence and nAChRs
    • 6. Alcohol Dependence, Comorbid Psychiatric Condition and nAChRs
    • 7. Alcohol, Transcription Factors, and nAChRs
    • 8. Conclusions
    • Acknowledgments

    Chapter Seven: Molecular Changes in Opioid Addiction: The Role of Adenylyl Cyclase and cAMP/PKA System

    • Abstract
    • 1. Introduction
    • 2. The Adenylyl Cyclase Pathway
    • 3. Opioid Effect on cAMP-Responsive Element-Binding Protein (CREB)
    • 4. Molecular Changes in Brain Regions That May Underlie Opiate Dependence
    • 5. Molecular Changes in the Ventral Tegmental Area
    • 6. Molecular Changes in Other CNS Regions
    • 7. Conclusions

    Chapter Eight: Caenorhabditis elegans as a Model to Study the Molecular and Genetic Mechanisms of Drug Addiction

    • Abstract
    • 1. Introduction
    • 2. Models of Addiction
    • 3. Invertebrate Models
    • 4. C. elegans as a Model System to Study Addiction
    • 5. Drugs of Abuse
    • 6. Convergent Mechanisms of Drugs of Abuse in C. elegans
    • 7. Leveraging C. elegans for Model Development and Drug Discovery
    • 8. Conclusions
    • Acknowledgment

Product details

  • No. of pages: 277
  • Language: English
  • Copyright: © Academic Press 2016
  • Published: January 12, 2016
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128037867
  • eBook ISBN: 9780128038680

About the Author

Shafiqur Rahman

Shafiqur Rahman, Ph.D. is Professor of Pharmacology in the Department of Pharmaceutical Sciences at South Dakota State University (SDSU) in Brookings, USA. He received his Ph.D. in Neuropharmacology from the Memorial University of Newfoundland, Canada. Dr. Rahman completed his post-doctoral fellowship in the Department of Psychiatry from Indiana University School of Medicine in Indianapolis in USA. Prior to joining SDSU, he worked as research scientist and faculty at the University of Kentucky in Lexington, USA and the University of Toronto, Canada. Dr. Rahman's research focus is drug discovery in neuropharmacology, i.e. the development of novel therapeutic candidates for the treatment of drug addiction and neuropsychiatric disorders. His research and scholarship has resulted in over 125 publications and 11 edited books/book chapters. Dr. Rahman served as editor, editorial board member and reviewer for numerous Scientific Journals and review panels related to drug addiction, neuropharmacology, and drug discovery research. Dr. Rahman is also a member of several professional societies or organizations, including Society for Neuroscience, American Society for Experimental Neurotherapeutics, and American Society for Pharmacology and Experimental Therapeutics.

Affiliations and Expertise

Professor, Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD, USA