The Macrophage In Neoplasia
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The Macrophage in Neoplasia is a compilation of papers presented at a workshop held at the Marine Biological Laboratory, Woods Hole, Massachusetts, on October 8-11, 1975. The book presents the many faceted activities of macrophage. This book is divided according to the five sessions of the workshop. First session talks about the role of tumor macrophages in vivo. It then elucidates the macrophage function and indicates how the interaction of macrophages with other cells can alter the host-tumor balance. The remaining sessions, as presented in this book, explore the mechanism of macrophage mediated cytotoxicity, functional expression of macrophages and neoplasia, and the stimulation of macrophage function and applied therapy.
Table of Contents
List of Participants
Preface
Session I: Role of Tumor Macrophages in Vivo
Role of Macrophages in Host Defense Mechanisms
Studies on the Hematogenous Dissemination of Technetium-99m Labeled Malignant Cells
Tumor Macrophages in Host Immunity t o Malignancies
Session II: Macrophage Function and Interaction
Introduction
Defective Macrophage Migration Produced by Neoplasms: Identification of An Inhibiter of Macrophage Chemotaxis
Macrophage Activation by Lymphocyte Mediators and Tumor Immunity: A Brief Review
Discussion
Session III: Mechanisms of Macrophage Mediated Cytotoxicity
The Macrophage as a Tumoricidal Effector Cell: A Review of in Vivo and in Vitro Studies on the Mechanism of the Activated Macrophage Nonspecific Cytotoxic Reaction
Morphologic Aspects of Tumor Cell Cytotoxicity by Effector Cells of the Macrophage-Histiocyte Compartment: in Vitro and in Vivo Studies in BCG-Meditated Tumor Regression
Mechanisms of Target Cell Destruction by Alloimmune Peritoneal Macrophages
Cytostatic and Cytocidal Effects of Activated Nonimmune Macrophages
Discussion
Session IV: Functional Expression of Macrophages and Neoplasia
Human Pulmonary Macrophages in Disease and Neoplasia
The Employment of Glucan and Glucan Activated Macrophages in the Enhancement of Host Resistance to Malignancies in Experimental Animals
Macrophages in Regressing Progressing Moloney Sarcomas
Discussion
Session V: Stimulation of Macrophage Function and Applied Therapy
Introduction
Peritoneal Macrophages from BCG-Infected Mice: Tumor Cytotoxicity and Chemotactic Responses in Vitro
The in Vivo Destruction of Human Tumor by Glucan Activated Macrophages
Macrophage Deficiency in Tumor Bearing Animals: Control of Experimental Metastasis With Macrophages Activated in Vitro
Discussion
Antagonism of Immunosuppression by BCG
Product details
- No. of pages: 276
- Language: English
- Copyright: © Academic Press 1976
- Published: January 1, 1976
- Imprint: Academic Press
- eBook ISBN: 9780323158152