The Macrophage In Neoplasia

The Macrophage in Neoplasia is a compilation of papers presented at a workshop held at the Marine Biological Laboratory, Woods Hole, Massachusetts, on October 8-11, 1975. The book presents the many faceted activities of macrophage. This book is divided according to the five sessions of the workshop. First session talks about the role of tumor macrophages in vivo. It then elucidates the macrophage function and indicates how the interaction of macrophages with other cells can alter the host-tumor balance. The remaining sessions, as presented in this book, explore the mechanism of macrophage mediated cytotoxicity, functional expression of macrophages and neoplasia, and the stimulation of macrophage function and applied therapy.

List of Participants

Preface

Session I: Role of Tumor Macrophages in Vivo

Role of Macrophages in Host Defense Mechanisms

Studies on the Hematogenous Dissemination of Technetium-99m Labeled Malignant Cells

Tumor Macrophages in Host Immunity t o Malignancies

Session II: Macrophage Function and Interaction

Introduction

Defective Macrophage Migration Produced by Neoplasms: Identification of An Inhibiter of Macrophage Chemotaxis

Macrophage Activation by Lymphocyte Mediators and Tumor Immunity: A Brief Review

Discussion

Session III: Mechanisms of Macrophage Mediated Cytotoxicity

The Macrophage as a Tumoricidal Effector Cell: A Review of in Vivo and in Vitro Studies on the Mechanism of the Activated Macrophage Nonspecific Cytotoxic Reaction

Morphologic Aspects of Tumor Cell Cytotoxicity by Effector Cells of the Macrophage-Histiocyte Compartment: in Vitro and in Vivo Studies in BCG-Meditated Tumor Regression

Mechanisms of Target Cell Destruction by Alloimmune Peritoneal Macrophages

Cytostatic and Cytocidal Effects of Activated Nonimmune Macrophages

Discussion

Session IV: Functional Expression of Macrophages and Neoplasia

Human Pulmonary Macrophages in Disease and Neoplasia

The Employment of Glucan and Glucan Activated Macrophages in the Enhancement of Host Resistance to Malignancies in Experimental Animals

Macrophages in Regressing Progressing Moloney Sarcomas

Discussion

Session V: Stimulation of Macrophage Function and Applied Therapy

Introduction

Peritoneal Macrophages from BCG-Infected Mice: Tumor Cytotoxicity and Chemotactic Responses in Vitro

The in Vivo Destruction of Human Tumor by Glucan Activated Macrophages

Macrophage Deficiency in Tumor Bearing Animals: Control of Experimental Metastasis With Macrophages Activated in Vitro

Discussion

Antagonism of Immunosuppression by BCG