The Macrophage In Neoplasia

The Macrophage In Neoplasia

1st Edition - January 1, 1976

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  • Editor: Mary Fink
  • eBook ISBN: 9780323158152

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Description

The Macrophage in Neoplasia is a compilation of papers presented at a workshop held at the Marine Biological Laboratory, Woods Hole, Massachusetts, on October 8-11, 1975. The book presents the many faceted activities of macrophage. This book is divided according to the five sessions of the workshop. First session talks about the role of tumor macrophages in vivo. It then elucidates the macrophage function and indicates how the interaction of macrophages with other cells can alter the host-tumor balance. The remaining sessions, as presented in this book, explore the mechanism of macrophage mediated cytotoxicity, functional expression of macrophages and neoplasia, and the stimulation of macrophage function and applied therapy.

Table of Contents


  • List of Participants

    Preface

    Session I: Role of Tumor Macrophages in Vivo

    Role of Macrophages in Host Defense Mechanisms

    Studies on the Hematogenous Dissemination of Technetium-99m Labeled Malignant Cells

    Tumor Macrophages in Host Immunity t o Malignancies

    Session II: Macrophage Function and Interaction

    Introduction

    Defective Macrophage Migration Produced by Neoplasms: Identification of An Inhibiter of Macrophage Chemotaxis

    Macrophage Activation by Lymphocyte Mediators and Tumor Immunity: A Brief Review

    Discussion

    Session III: Mechanisms of Macrophage Mediated Cytotoxicity

    The Macrophage as a Tumoricidal Effector Cell: A Review of in Vivo and in Vitro Studies on the Mechanism of the Activated Macrophage Nonspecific Cytotoxic Reaction

    Morphologic Aspects of Tumor Cell Cytotoxicity by Effector Cells of the Macrophage-Histiocyte Compartment: in Vitro and in Vivo Studies in BCG-Meditated Tumor Regression

    Mechanisms of Target Cell Destruction by Alloimmune Peritoneal Macrophages

    Cytostatic and Cytocidal Effects of Activated Nonimmune Macrophages

    Discussion

    Session IV: Functional Expression of Macrophages and Neoplasia

    Human Pulmonary Macrophages in Disease and Neoplasia

    The Employment of Glucan and Glucan Activated Macrophages in the Enhancement of Host Resistance to Malignancies in Experimental Animals

    Macrophages in Regressing Progressing Moloney Sarcomas

    Discussion

    Session V: Stimulation of Macrophage Function and Applied Therapy

    Introduction

    Peritoneal Macrophages from BCG-Infected Mice: Tumor Cytotoxicity and Chemotactic Responses in Vitro

    The in Vivo Destruction of Human Tumor by Glucan Activated Macrophages

    Macrophage Deficiency in Tumor Bearing Animals: Control of Experimental Metastasis With Macrophages Activated in Vitro

    Discussion

    Antagonism of Immunosuppression by BCG


Product details

  • No. of pages: 276
  • Language: English
  • Copyright: © Academic Press 1976
  • Published: January 1, 1976
  • Imprint: Academic Press
  • eBook ISBN: 9780323158152

About the Editor

Mary Fink

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