The Liver

The Liver

Morphology, Biochemistry, Physiology

1st Edition - January 1, 1963

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  • Editor: Ch. Rouiller
  • eBook ISBN: 9781483271750

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The Liver: Morphology, Biochemistry, Physiology, Volume I focuses on the advancement of knowledge on the liver under normal and pathological conditions, as revealed by morphological and physiological studies. The selection first offers information on the embryonic liver and anatomy of the liver, including morphology and physiology of the embryonic liver, histology of the liver, surgical segments, and vascular gross anatomy of the liver. The text then elaborates on the structure of the liver sinusoids and the sinusoidal cells and the cyto- and histochemistry of the liver. Topics include protein reactions, nucleic acids, glycogen, lipids, heavy metals, and morphological aspects of lining cells. The publication examines electron microscopy of the liver; acinar units and the pathophysiology of the liver; and dynamics of circulation in the liver. Discussions focus on oxygen transport and consumption in the liver; experimental alterations of the hepatic circulation; hexagonal pattern and the interdigitation of the afferent and efferent vascular trees; and simple liver acinus. The selection is a dependable source of data for morphologists, biochemists, pharmacologists, and clinicians.

Table of Contents

  • Contributors


    Contents of Volume II

    1. The Embryonic Liver

    I. Morphology

    II. Embryonic Liver Physiology


    2. Anatomy of the Liver

    I. Histology of the Liver

    II. Vascular Gross Anatomy of the Liver

    III. Surgical Segments


    3. The Structure of the Liver Sinusoids and the Sinusoidal Cells

    I. Historical and Theoretical Considerations

    II. Morphological Aspects of Lining Cells

    III. The Basement Membrane and the "Space of Disse"

    IV. Electron Microscopic Findings


    4. Cyto- and Histochemistry of the Liver

    I. Introduction

    II. Nucleic Acids

    III. Protein Reactions

    IV. Glycogen

    V. PAS-Positive Nonglycogenic Material

    VI. Lipids

    VII. Heavy Metals

    VIII. Enzymatic Staining Reactions

    IX. Discussion


    5. Electron Microscopy of the Liver

    I. Introduction

    II. The Hepatic Cell

    III. The Biliary Pathways

    IV. The Blood Sinusoids, the Kupffer Cell, and the Perisinusoidal Space


    6. Acinar Units and the Pathophysiology of the Liver

    I. Historical Note on the Microlobulation of the Liver

    II. Simple Liver Acinus

    III. The Complex Liver Acinus and the Acinar Agglomerate

    IV. Hexagonal Pattern and the Interdigitation of the Afferent and Efferent Vascular Trees

    V. Pathways of Hepatic Circulation

    VI. Lines and Patterns Deriving from the Acinar Units for the Orientation of Hepatic Lesions

    VII. Functional Anatomical Interpretation of Classical Notions in Pathology

    VIII. Common Lesions in the Structural and Functional Units of the Human Liver

    IX. Summary


    7. Dynamics of the Circulation in the Liver

    I. Methodological Considerations

    II. Results of Various Estimations of Hepatic Blood Flow

    III. Oxygen Transport and Consumption in the Liver

    IV. Hepatic Fractions of the Cardiac Output

    V. Hepatic Circulation in Diseases of the Liver

    VI. The Portal Pressure

    VII. Experimental Alterations of the Hepatic Circulation

    VIII. Concluding Remarks


    8. The Cell Components of the Liver Isolation, Morphology, Biochemistry

    I. Introduction

    II. Isolation of Cell Components

    III. Morphology of Isolated Fractions

    IV. Biochemistry of Isolated Cell Components

    V. Conclusions

    VI. Appendix: Isolated Liver Cells


    9. Metabolism of Amino Acids and Proteins

    I. Introduction

    II. General Picture of Amino Acid and Protein Metabolism

    III. Free Amino Acid Levels: Concentration of Amino Acids by the Liver

    IV. The Removal of Nitrogen as Ammonia from Amino Acids

    V. Transamination of Amino Acids

    VI. Other Mechanisms for the Removal of Nitrogen

    VII. Urea Metabolism

    VIII. Ammonia Metabolism

    IX. Creatine-Creatinine Metabolism

    X. Synthesis of Conjugates of Amino Acids

    XI. Further Metabolism of Amino Acids

    XII. Protein Metabolism


    10. The Liver and Lipid Metabolism

    I. Introduction: The General Role of the Liver

    II. The Hepatic Lipids

    III. Metabolism of the Fatty Acids

    IV. The Synthesis and the Degradation of Phospholipids

    V. The Liver and the Circulating Lipids

    VI. The Liver and the Metabolism of Cholesterol


    11. The Liver and Carbohydrate Metabolism

    I. Introduction

    II. Metabolism

    III. Carbohydrate Metabolism and Hepatic Conjugation

    IV. Energetics of Carbohydrate Metabolism

    V. Mechanisms for the Regulation of Carbohydrate Metabolism

    VI. Carbohydrate Metabolism as a Function of the Development State of the Organism

    VII. Metabolic Diseases Due to Deficiencies in Enzymes of Carbohydrate Metabolism


    Author Index

    Subject Index

Product details

  • No. of pages: 696
  • Language: English
  • Copyright: © Academic Press 1963
  • Published: January 1, 1963
  • Imprint: Academic Press
  • eBook ISBN: 9781483271750

About the Editor

Ch. Rouiller

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